THIFLUZAMIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C13H6Br2F6N2O2S
Molecular Weight	528.062
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=NC(=C(S1)C(=O)NC2=C(Br)C=C(OC(F)(F)F)C=C2Br)C(F)(F)F

InChI

InChIKey=WOSNCVAPUOFXEH-UHFFFAOYSA-N

InChI=1S/C13H6Br2F6N2O2S/c1-4-22-10(12(16,17)18)9(26-4)11(24)23-8-6(14)2-5(3-7(8)15)25-13(19,20)21/h2-3H,1H3,(H,23,24)

HIDE SMILES / InChI

Molecular Formula	C13H6Br2F6N2O2S
Molecular Weight	528.062
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.chemservice.com/news/2014/06/get-a-better-picture-of-thifluzamide/ | https://www.ncbi.nlm.nih.gov/pubmed/26453237

Thifluzamide is a powerful and effective fungicide. When used safely and correctly it can be effective on rice and other crops because of improved water dispersal techniques. Thifluzamide is highly active against Basidiomycete fungi, in particular Rhizoctonia solani, primarily in rice, potatoes, and turf markets.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Ceratobasidium cereale 1 Target ID: CHEMBL613340 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26453237 \| https://www.ncbi.nlm.nih.gov/pubmed/27415408	Inhibitor 8297
succinate dehydrogenase activity 3 Target ID: GO:0000104 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26453237 \| https://www.ncbi.nlm.nih.gov/pubmed/27415408	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

The EC50 values for thifluzamidein inhibiting mycelial growth of R. cerealis varied from 0.025 to0.36 ug/ml, with a mean of 0.064 ± 0.013 ug/ml.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:08:16 GMT 2023` Edited by `admin` on `Fri Dec 15 19:08:16 GMT 2023`
Record UNII	2J3TB6Z254
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

THIFLUZAMIDE

Common Name

English

THIFLUZAMIDE [ISO]

Common Name

English

2',6'-DIBROMO-2-METHYL-4'-TRIFLUOROMETHOXY-4-TRIFLUOROMETHYL-1,3-THIAZOLE-5-CARBOXANILIDE

Systematic Name

English

THIFLUZAMIDE [MI]

Common Name

English

N-(2,6-DIBROMO-4-(TRIFLUOROMETHOXY)PHENYL)-2-METHYL-4-(TRIFLUOROMETHYL)-5-THIAZOLECARBOXAMIDE

Systematic Name

English

Code System Code Type Description

PUBCHEM

86389