Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C8H14O2 |
| Molecular Weight | 142.1956 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCC(CC=C)C(O)=O
InChI
InChIKey=UMYDNZXEHYSVFY-UHFFFAOYSA-N
InChI=1S/C8H14O2/c1-3-5-7(6-4-2)8(9)10/h3,7H,1,4-6H2,2H3,(H,9,10)
| Molecular Formula | C8H14O2 |
| Molecular Weight | 142.1956 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Role of oxidative metabolism in the effect of valproic acid on markers of cell viability, necrosis, and oxidative stress in sandwich-cultured rat hepatocytes. | 2010-12 |
|
| Dose-dependent pharmacokinetics of toxic metabolites is not related to increased toxicity following high-dose valproic acid in rats. | 2010-11 |
|
| Formulations of valproate alter valproate metabolism: a single oral dose kinetic study. | 2009-10 |
|
| The relationship between glucuronide conjugate levels and hepatotoxicity after oral administration of valproic acid. | 2009-07 |
|
| Pyruvate uptake is inhibited by valproic acid and metabolites in mitochondrial membranes. | 2008-10-15 |
|
| Quantification of valproic acid and its metabolite 2-propyl-4-pentenoic acid in human plasma using HPLC-MS/MS. | 2007-05-01 |
|
| Contribution of CYP2C9, CYP2A6, and CYP2B6 to valproic acid metabolism in hepatic microsomes from individuals with the CYP2C9*1/*1 genotype. | 2006-12 |
|
| Science review: carnitine in the treatment of valproic acid-induced toxicity - what is the evidence? | 2005-10-05 |
|
| Histone deacetylases inhibition and tumor cells cytotoxicity by CNS-active VPA constitutional isomers and derivatives. | 2005-05-15 |
|
| Differential effect of valproate and its Delta2- and Delta4-unsaturated metabolites, on the beta-oxidation rate of long-chain and medium-chain fatty acids. | 2001-09-28 |
|
| Fluorinated analogues as mechanistic probes in valproic acid hepatotoxicity: hepatic microvesicular steatosis and glutathione status. | 1995-07-01 |
|
| On the development of alternative antiepileptic drugs. Lack of enantioselectivity of the anticonvulsant activity, in contrast to teratogenicity, of 2-n-propyl-4-pentenoic acid and 2-n-propyl-4-pentynoic acid, analogues of the anticonvulsant drug valproic acid. | 1991-06 |
|
| Asymmetric synthesis and enantioselective teratogenicity of 2-n-propyl-4-pentenoic acid (4-en-VPA), an active metabolite of the anticonvulsant drug, valproic acid. | 1989-10 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 21:51:21 GMT 2025
by
admin
on
Mon Mar 31 21:51:21 GMT 2025
|
| Record UNII |
2GYI36I25W
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
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Preferred Name | English | ||
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Systematic Name | English | ||
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Systematic Name | English |
| Code System | Code | Type | Description | ||
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DTXSID20881257
Created by
admin on Mon Mar 31 21:51:21 GMT 2025 , Edited by admin on Mon Mar 31 21:51:21 GMT 2025
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1575-72-0
Created by
admin on Mon Mar 31 21:51:21 GMT 2025 , Edited by admin on Mon Mar 31 21:51:21 GMT 2025
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2GYI36I25W
Created by
admin on Mon Mar 31 21:51:21 GMT 2025 , Edited by admin on Mon Mar 31 21:51:21 GMT 2025
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104896
Created by
admin on Mon Mar 31 21:51:21 GMT 2025 , Edited by admin on Mon Mar 31 21:51:21 GMT 2025
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> METABOLITE TOXIC |
MINOR
URINE
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