Dazagamglogene Autogedtemcel

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Wed Apr 02 07:40:03 GMT 2025` Edited by `admin` on `Wed Apr 02 07:40:03 GMT 2025`
Source Materials Class	ORGANISM
Source Materials Type	HUMAN
Source Materials State	LIVE
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	blood
Fraction Material Type	cells
Fraction Name	hematopoietic stem and progenitor cells (hspcs)
Record UNII	2GNP7PE0CG
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Dazagamglogene Autogedtemcel

Official Name

English

Autologous CD34+ hematopoietic stem and progenitor cells (HSPCs) collected by leukapheresis and genetically modified ex vivo by a pair of zinc finger nucleases (ZFN) directed against the genomic sequence of the erythroid-specific enhancer (ESE) located i

Preferred Name

English

dazagamglogene autogedtemcel [INN]

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C203029

Created by admin on Wed Apr 02 07:40:03 GMT 2025 , Edited by admin on Wed Apr 02 07:40:03 GMT 2025

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FDA UNII

2GNP7PE0CG

Created by admin on Wed Apr 02 07:40:03 GMT 2025 , Edited by admin on Wed Apr 02 07:40:03 GMT 2025

PRIMARY

INN

12741

Created by admin on Wed Apr 02 07:40:03 GMT 2025 , Edited by admin on Wed Apr 02 07:40:03 GMT 2025

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Related Record Type Details


					2GNP7PE0CG

Dazagamglogene Autogedtemcel

ACTIVE MOIETY

Comments:

Severe Sickle Cell Disease

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Fragment Name	Fragment ID
CULTURE	EXPANSION	CELL SEPARATION	UNSPECIFIED SUBSTANCE	9cd8c8f9
TRANSFECTION FOLLOWED BY EXPANSION AND RELEASE FROM MAGNETIC BEADS	TRANSFECTION	Gene delivery by mRNA electroporation	mRENH1	1DSV7GF306
TRANSFECTION FOLLOWED BY EXPANSION AND RELEASE FROM MAGNETIC BEADS	TRANSFECTION	Gene delivery by mRNA electroporation	mRENH2	RB6ZJ0EJ1O