Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C37H40N2O6.ClH |
| Molecular Weight | 645.184 |
| Optical Activity | ( + ) |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.[H][C@@]12CC3=CC=C(OC4=CC(C[C@@]5([H])N(C)CCC6=C5C(OC7=C(OC)C=C(CCN1C)C2=C7)=C(OC)C(OC)=C6)=CC=C4O)C=C3
InChI
InChIKey=SFPGJACKHKXGBH-QBYKQQEBSA-N
InChI=1S/C37H40N2O6.ClH/c1-38-14-12-24-19-32(41-3)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-31-18-23(8-11-30(31)40)17-29-35-25(13-15-39(29)2)20-34(42-4)36(43-5)37(35)45-33;/h6-11,18-21,28-29,40H,12-17H2,1-5H3;1H/t28-,29+;/m0./s1
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C37H40N2O6 |
| Molecular Weight | 608.7233 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| A comparative study on the anti-inflammatory, antinociceptive and antipyretic effects of isoquinoline alkaloids from the roots of Turkish Berberis species. | 2002 Dec 27 |
|
| The effect of calmodulin antagonist berbaminederivative-EBB on hepatoma in vitro and in vivo. | 2002 May |
|
| Inhibition of Na(+),K(+)-ATPase by the extract of Stephania cephararantha HAYATA and bisbenzylisoquinoline alkaloid cycleanine, a major constituent. | 2003 Aug 1 |
|
| Effect of E6, a novel calmodulin inhibitor, on activity of P-glycoprotein in purified primary cultured rat brain microvessel endothelial cells. | 2003 Nov |
|
| [Distribution of four alkaloids in plants of Berberis]. | 2004 Feb |
|
| [Comparison of the anti-arrhythmic effects of matrine and berbamine with amiodarone and RP58866]. | 2004 Sep |
|
| [Study on effect of berbamine on multidrug resistance leukemia K562/Adr cells]. | 2004 Sep |
|
| [Effects of berbamine on K562 cells and its mechanisms in vitro and in vivo]. | 2005 Jun |
|
| Free radical scavenging activity and lipoxygenase inhibition of Mahonia aquifolium extract and isoquinoline alkaloids. | 2007 Jul 16 |
|
| Novel immunomodulatory properties of berbamine through selective down-regulation of STAT4 and action of IFN-gamma in experimental autoimmune encephalomyelitis. | 2008 Jul 15 |
|
| Studies on alkaloids binding to GC-rich human survivin promoter DNA using positive and negative ion electrospray ionization mass spectrometry. | 2008 Mar |
|
| Harnessing gene expression to identify the genetic basis of drug resistance. | 2009 |
|
| Effects of theanine on growth of human lung cancer and leukemia cells as well as migration and invasion of human lung cancer cells. | 2009 Apr |
|
| Berbamine exhibits potent antitumor effects on imatinib-resistant CML cells in vitro and in vivo. | 2009 Apr |
|
| The antiproliferation effect of berbamine on k562 resistant cells by inhibiting NF-kappaB pathway. | 2009 Jul |
|
| A new dawn for the use of traditional Chinese medicine in cancer therapy. | 2009 Mar 20 |
|
| Suppression of growth, migration and invasion of highly-metastatic human breast cancer cells by berbamine and its molecular mechanisms of action. | 2009 Oct 1 |
|
| A novel calmodulin antagonist O-(4-ethoxyl-butyl)-berbamine overcomes multidrug resistance in drug-resistant MCF-7/ADR breast carcinoma cells. | 2010 Jul |
|
| Degradation of HER2/neu by ANT2 shRNA suppresses migration and invasiveness of breast cancer cells. | 2010 Jul 23 |
|
| Circumvention of multi-drug resistance of cancer cells by Chinese herbal medicines. | 2010 Jul 25 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 19:33:36 GMT 2023
by
admin
on
Sat Dec 16 19:33:36 GMT 2023
|
| Record UNII |
2FAW2F3Q2Z
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
69475-26-9
Created by
admin on Sat Dec 16 19:33:37 GMT 2023 , Edited by admin on Sat Dec 16 19:33:37 GMT 2023
|
PRIMARY | |||
|
2FAW2F3Q2Z
Created by
admin on Sat Dec 16 19:33:37 GMT 2023 , Edited by admin on Sat Dec 16 19:33:37 GMT 2023
|
PRIMARY | |||
|
56845155
Created by
admin on Sat Dec 16 19:33:37 GMT 2023 , Edited by admin on Sat Dec 16 19:33:37 GMT 2023
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
SOLVATE->ANHYDROUS |
|
||
|
PARENT -> SALT/SOLVATE |
|
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
ACTIVE MOIETY |
|