Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C37H40N2O6.ClH |
| Molecular Weight | 645.184 |
| Optical Activity | ( + ) |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.[H][C@@]12CC3=CC=C(OC4=CC(C[C@@]5([H])N(C)CCC6=C5C(OC7=C(OC)C=C(CCN1C)C2=C7)=C(OC)C(OC)=C6)=CC=C4O)C=C3
InChI
InChIKey=SFPGJACKHKXGBH-QBYKQQEBSA-N
InChI=1S/C37H40N2O6.ClH/c1-38-14-12-24-19-32(41-3)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-31-18-23(8-11-30(31)40)17-29-35-25(13-15-39(29)2)20-34(42-4)36(43-5)37(35)45-33;/h6-11,18-21,28-29,40H,12-17H2,1-5H3;1H/t28-,29+;/m0./s1
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C37H40N2O6 |
| Molecular Weight | 608.7233 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Protection of T cells from radiation-induced apoptosis by Cepharanthin. | 2001 Nov |
|
| In vitro effect of alkaloids on bloodstream forms of Trypanosoma brucei and T. congolense. | 2001 Oct |
|
| A comparative study on the anti-inflammatory, antinociceptive and antipyretic effects of isoquinoline alkaloids from the roots of Turkish Berberis species. | 2002 Dec 27 |
|
| Effect of Mahonia aquifolium active compounds on interleukin-8 production in the human monocytic cell line THP-1. | 2002 Mar |
|
| The effect of calmodulin antagonist berbaminederivative-EBB on hepatoma in vitro and in vivo. | 2002 May |
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| Interaction of multidrug resistance reversal agents with P-glycoprotein ATPase activity on blood-brain barrier. | 2002 May |
|
| Inhibition of Na(+),K(+)-ATPase by the extract of Stephania cephararantha HAYATA and bisbenzylisoquinoline alkaloid cycleanine, a major constituent. | 2003 Aug 1 |
|
| [Reversal effect of berbamine on multidrug resistance of K562/A02 cells and its mechanism]. | 2003 Dec |
|
| [Detection of P-170 and treatment with berbamine in primary acute leukemia]. | 2003 Feb |
|
| Integrity of actin-network is involved in uridine 5'-triphosphate evoked store-operated Ca2+ entry in bovine adrenocortical fasciculata cells. | 2003 Jan |
|
| Effect of E6, a novel calmodulin inhibitor, on activity of P-glycoprotein in purified primary cultured rat brain microvessel endothelial cells. | 2003 Nov |
|
| [Distribution of four alkaloids in plants of Berberis]. | 2004 Feb |
|
| [Comparison of the anti-arrhythmic effects of matrine and berbamine with amiodarone and RP58866]. | 2004 Sep |
|
| [Effects of berbamine on K562 cells and its mechanisms in vitro and in vivo]. | 2005 Jun |
|
| [The mechanism of apoptosis of chronic myeloid leukemia cells induced by the novel p210 bcr/abl inhibitor berbamine]. | 2006 Aug 29 |
|
| Berbamine: a novel inhibitor of bcr/abl fusion gene with potent anti-leukemia activity. | 2006 Jan |
|
| [Effects of berbamine on growth of leukemia cell line NB4 and its mechanism]. | 2006 Mar |
|
| Regulatory T cells, a potent immunoregulatory target for CAM researchers: modulating tumor immunity, autoimmunity and alloreactive immunity (III). | 2006 Sep |
|
| Berbamine induces apoptosis in human hepatoma cell line SMMC7721 by loss in mitochondrial transmembrane potential and caspase activation. | 2007 Apr |
|
| Free radical scavenging activity and lipoxygenase inhibition of Mahonia aquifolium extract and isoquinoline alkaloids. | 2007 Jul 16 |
|
| Berbamine selectively induces apoptosis of human acute promyelocytic leukemia cells via survivin-mediated pathway. | 2007 May 5 |
|
| Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine. | 2008 Aug |
|
| Novel immunomodulatory properties of berbamine through selective down-regulation of STAT4 and action of IFN-gamma in experimental autoimmune encephalomyelitis. | 2008 Jul 15 |
|
| Studies on alkaloids binding to GC-rich human survivin promoter DNA using positive and negative ion electrospray ionization mass spectrometry. | 2008 Mar |
|
| Harnessing gene expression to identify the genetic basis of drug resistance. | 2009 |
|
| Berbamine induces Fas-mediated apoptosis in human hepatocellular carcinoma HepG2 cells and inhibits its tumor growth in nude mice. | 2009 |
|
| Effects of theanine on growth of human lung cancer and leukemia cells as well as migration and invasion of human lung cancer cells. | 2009 Apr |
|
| Berbamine exhibits potent antitumor effects on imatinib-resistant CML cells in vitro and in vivo. | 2009 Apr |
|
| Berbamine derivatives: a novel class of compounds for anti-leukemia activity. | 2009 Aug |
|
| Berbamine, a novel nuclear factor kappaB inhibitor, inhibits growth and induces apoptosis in human myeloma cells. | 2009 Dec |
|
| The antiproliferation effect of berbamine on k562 resistant cells by inhibiting NF-kappaB pathway. | 2009 Jul |
|
| Probing the binding sites and the effect of berbamine on the structure of bovine serum albumin. | 2009 Jun |
|
| A new dawn for the use of traditional Chinese medicine in cancer therapy. | 2009 Mar 20 |
|
| Antihyperglycemic and antioxidant effect of Berberis aristata root extract and its role in regulating carbohydrate metabolism in diabetic rats. | 2009 May 4 |
|
| Suppression of growth, migration and invasion of highly-metastatic human breast cancer cells by berbamine and its molecular mechanisms of action. | 2009 Oct 1 |
|
| [Berbamine induces apoptosis of multiple myeloma RPMI 8226 cells by activating GADD45/JNK pathway]. | 2009 Sep |
|
| Suppression of human lung cancer cell growth and migration by berbamine. | 2010 Aug |
|
| Traditional herbal medicine in far-west Nepal: a pharmacological appraisal. | 2010 Dec 13 |
|
| A novel calmodulin antagonist O-(4-ethoxyl-butyl)-berbamine overcomes multidrug resistance in drug-resistant MCF-7/ADR breast carcinoma cells. | 2010 Jul |
|
| Degradation of HER2/neu by ANT2 shRNA suppresses migration and invasiveness of breast cancer cells. | 2010 Jul 23 |
|
| Circumvention of multi-drug resistance of cancer cells by Chinese herbal medicines. | 2010 Jul 25 |
|
| 4-Chlorobenzoyl berbamine induces apoptosis and G2/M cell cycle arrest through the PI3K/Akt and NF-kappaB signal pathway in lymphoma cells. | 2010 Mar |
|
| Tissue culture and generation of autotetraploid plants of Sophora flavescens Aiton. | 2010 Oct |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 19:33:36 GMT 2023
by
admin
on
Sat Dec 16 19:33:36 GMT 2023
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| Record UNII |
2FAW2F3Q2Z
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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Systematic Name | English |
| Code System | Code | Type | Description | ||
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69475-26-9
Created by
admin on Sat Dec 16 19:33:37 GMT 2023 , Edited by admin on Sat Dec 16 19:33:37 GMT 2023
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2FAW2F3Q2Z
Created by
admin on Sat Dec 16 19:33:37 GMT 2023 , Edited by admin on Sat Dec 16 19:33:37 GMT 2023
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56845155
Created by
admin on Sat Dec 16 19:33:37 GMT 2023 , Edited by admin on Sat Dec 16 19:33:37 GMT 2023
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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SOLVATE->ANHYDROUS |
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PARENT -> SALT/SOLVATE |
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
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