SODIUM MALATE

Details

Stereochemistry	RACEMIC
Molecular Formula	C4H4O5.2Na
Molecular Weight	178.0511
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].[Na+].OC(CC([O-])=O)C([O-])=O

InChI

InChIKey=WPUMTJGUQUYPIV-UHFFFAOYSA-L

InChI=1S/C4H6O5.2Na/c5-2(4(8)9)1-3(6)7;;/h2,5H,1H2,(H,6,7)(H,8,9);;/q;2*+1/p-2

HIDE SMILES / InChI

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C4H4O5
Molecular Weight	132.0716
Charge	-2
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: http://gov.personalcarecouncil.org/ctfa-static/online/lists/cir-pdfs/FR330.pdf | https://www.montavit.com/sites/default/files/produktdownloads/pil_acerbine_solution_06022015.pdfhttp://www.cosmeticsinfo.org/ingredient/sodium-malate | https://www.food.gov.uk/science/additives/enumberlist#h_7 | https://www.ncbi.nlm.nih.gov/pubmed/11358110 | https://www.ncbi.nlm.nih.gov/pubmed/9477166

Malic acid is a tart-tasting organic dicarboxylic acid that contributes to the taste of many sour or tart foods such as apples. Sodium Malate is the sodium salt of Malic Acid. Malic Acid and Sodium Malate can be found in a wide range of cosmetics and personal care products. Sodium Malate functions as a skin conditioning agent-humectant. As a food additive, Sodium Malate has the E number E350. Sodium Malate has demonstrated protective effect on cisplatin-induced toxicity in mice. Sodium malate could become a useful agent for the reduction of CDDP-induced toxicity, particularly nephrotoxicity and hepatotoxicity.

Originator

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Cisplatin-induced toxicity 5 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9477166 https://www.ncbi.nlm.nih.gov/pubmed/9514605	Secondary	Preclinical	Unknown Approved Use Unknown
Cardiac arrhythmia 19 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8974556 https://www.ncbi.nlm.nih.gov/pubmed/1458176	Preventing	Preclinical	Unknown Approved Use Unknown
Skin injuries 8 Sources: https://www.montavit.com/sites/default/files/produktdownloads/pil_acerbine_solution_06022015.pdf	Curative	Approved 8429	ACERBINE Approved Use Acerbine solution is suitable for the treatment of superficial skin injuries, such as burns, scalds, sunburn, wounds and abrasions.

PubMed

Title	Date	PubMed
Variation of isoenzyme and RAPD patterns in Candida albicans morphological mutants with altered colony ultrastructure.	2001	11426863
Metabolic regulation of pH in plant cells: role of cytoplasmic pH in defense reaction and secondary metabolism.	2001	11407758
Final report on the safety assessment of Malic Acid and Sodium Malate.	2001	11358110
Survey of normal appearing mouse strain which lacks malic enzyme and Nad+-linked glycerol phosphate dehydrogenase: normal pancreatic beta cell function, but abnormal metabolite pattern in skeletal muscle.	2001 Apr	11451371
Single-cell dissection and microdroplet chemistry.	2001 Apr	11373308
Physiological basis of reduced AL tolerance in ditelosomic lines of Chinese Spring wheat.	2001 Apr	11346958
Inhibiting expression of a tomato ripening-associated membrane protein increases organic acids and reduces sugar levels of fruit.	2001 Apr	11346954
Reevaluating the free-ion activity model of trace metal toxicity toward higher plants: experimental evidence with copper and zinc.	2001 Apr	11345467
Effect of an antidiabetic extract of Catharanthus roseus on enzymic activities in streptozotocin induced diabetic rats.	2001 Aug	11448549
Carbohydrate deprivation reduces NADPH-production in fish liver but not in adipose tissue.	2001 Aug	11404182
Characterization of a novel complex from halophilic archaebacteria, which displays chaperone-like activities in vitro.	2001 Aug 10	11395490
Structural analyses of a malate dehydrogenase with a variable active site.	2001 Aug 17	11389141
Alteration of the specificity of malate dehydrogenase by chemical modulation of an active site arginine.	2001 Aug 17	11389140
[Lactate and malate dehydrogenase activity in the sterlet and Russian sturgeon under conditions of the widespread muscular pathology].	2001 Jan-Feb	11424523
Malo-ethanolic fermentation in grape must by recombinant strains of Saccharomyces cerevisiae.	2001 Jul	11447602
Thyroid hormone--sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform--specific.	2001 Jul	11435461
Massive sequence comparisons as a help in annotating genomic sequences.	2001 Jul	11435413
Altered expression and function of mitochondrial beta-oxidation enzymes in juvenile intrauterine-growth-retarded rat skeletal muscle.	2001 Jul	11420423
Relationships between inhibition constants, inhibitor concentrations for 50% inhibition and types of inhibition: new ways of analysing data.	2001 Jul 1	11415458
pH-dependent investigations of vanadium(V)-peroxo-malate complexes from aqueous solutions. In search of biologically relevant vanadium(V)-peroxo species.	2001 Jul 16	11442368
Metabolic flux analysis for succinic acid production by recombinant Escherichia coli with amplified malic enzyme activity.	2001 Jul 20	11369997
Transcriptome meets metabolome: hierarchical and metabolic regulation of the glycolytic pathway.	2001 Jul 6	11445079
The first examples of (S)-2-hydroxyacid dehydrogenases catalyzing the transfer of the pro-4S hydrogen of NADH are found in the archaea.	2001 Jul 9	11451450
The effect of nucleotides and mitochondrial chaperonin 10 on the structure and chaperone activity of mitochondrial chaperonin 60.	2001 Jun	11422376
Two-dimensional electrophoresis and characterization of antigens from Paracoccidioides brasiliensis.	2001 Jun	11418327
Inducible and constitutive expression using new plasmid and integrative expression vectors for Thermus sp.	2001 Jun	11412354
Aluminum speciation studies in biological fluids. Part 7. A quantitative investigation of aluminum(III)-malate complex equilibria and their potential implications for aluminum metabolism and toxicity.	2001 Jun	11410234
Oral almotriptan vs. oral sumatriptan in the abortive treatment of migraine: a double-blind, randomized, parallel-group, optimum-dose comparison.	2001 Jun	11405809
Energetic determinants of tyrosine phosphorylation of focal adhesion proteins during hypoxia/reoxygenation of kidney proximal tubules.	2001 Jun	11395393
A pre-genetic study of the isoforms of malic enzyme associated with lipid accumulation in Mucor circinelloides.	2001 Jun	11390681
An NMR and enzyme study of the carbon metabolism of Neisseria meningitidis.	2001 Jun	11390678
Myoadenylate deaminase deficiency does not affect muscle anaplerosis during exhaustive exercise in humans.	2001 Jun 15	11410643
Histochemical study of acute and chronic intraperitoneal nicotine effects on several glycolytic and Krebs cycle dehydrogenase activities in the frontoparietal cortex and subcortical nuclei of the rat brain.	2001 Jun 15	11398187
An NMR-based metabonomic approach to the investigation of coelomic fluid biochemistry in earthworms under toxic stress.	2001 Jun 29	11434921
Non-photosynthetic 'malic enzyme' from maize: a constituvely expressed enzyme that responds to plant defence inducers.	2001 Mar	11352460
[Properties of gluconeogenesis enzymes from flatworms].	2001 Mar-Apr	11452789
Production of beta-thujaplicin in Cupressus lusitanica suspension cultures fed with organic acids and monoterpenes.	2001 May	11440113
Induction of a peroxisomal malate dehydrogenase isoform in liver of starved rats.	2001 May	11405883
Partial amino acid catabolism leading to the formation of alanine in Periophthalmodon schlosseri (mudskipper): a strategy that facilitates the use of amino acids as an energy source during locomotory activity on land.	2001 May	11398750
New phenolic constituents from the fruit juice of Phyllanthus emblica.	2001 May	11383602
Magnesium ameliorates aluminum rhizotoxicity in soybean by increasing citric acid production and exudation by roots.	2001 May	11382822
Comprehensive chemical profiling of gramineous plant root exudates using high-resolution NMR and MS.	2001 May	11382236
Cloning and functional characterization of the 5' flanking region of the human mitochondrial malic enzyme gene. Regulatory role of Sp1 and AP-2.	2001 May	11358520
Possible involvement of protein phosphorylation in aluminum-responsive malate efflux from wheat root apex.	2001 May	11351103
Aluminum activates a citrate-permeable anion channel in the aluminum-sensitive zone of the maize root apex. A comparison between an aluminum- sensitive and an aluminum-resistant cultivar.	2001 May	11351102
Total synthesis of (-)-rosmarinecine by intramolecular cycloaddition of (S)-malic acid derived pyrroline N-oxide.	2001 May 3	11348236
Determination of organic acids and inorganic anions in wine by isotachophoresis on a planar chip.	2001 May 4	11382288
Tricarboxylic acid cycle enzymes of the ectomycorrhizal basidiomycete, Suillus bovinus.	2001 May-Jun	11421446
Enzymatic computing.	2001 May-Jun	11386878
Assimilation of D-malate by Rhodobacter capsulatus E1F1.	2001 Sep	11400062

Patents

Sample Use Guides

In Vivo Use Guide

Apply Acerbine solution (malic acid, salicylic acid, benzoic acid) to the wound or damaged skin two or more times daily or moisten the dressing again. Once scar formation begins, one application a day is generally sufficient.

Route of Administration: Topical

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 04:55:30 GMT 2023` Edited by `admin` on `Sat Dec 16 04:55:30 GMT 2023`
Record UNII	2EFF9N315F
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SODIUM MALATE

Official Name

English

SODIUM MALATE [INCI]

Common Name

English

(±)-SODIUM MALATE

Systematic Name

English

DISODIUM DL-MALATE

Common Name

English

E-350(II)

Code

English

MALIC ACID SODIUM SALT

Common Name

English

SODIUM MALATE, (±)-

Systematic Name

English

INS-350(II)

Code

English

SODIUM DL-MALATE

Common Name

English

BUTANEDIOIC ACID, 2-HYDROXY-, SODIUM SALT (1:2)

Common Name

English

INS NO.350(II)

Code

English

SODIUM MALATE, DL-

Common Name

English

DISODIUM MALATE

Systematic Name

English

Classification Tree Code System Code

JECFA EVALUATION

INS-350(II)