Invikafusp Alfa

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NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 16:47:58 GMT 2025` Edited by `admin` on `Wed Apr 02 16:47:58 GMT 2025`
Protein Type	BISPECIFIC ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	2E6V84F6FT
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Invikafusp Alfa

Official Name

English

Immunoglobulin G1 [351-cysteine,368-serine,370-alanine,409-valine,de-448-glycine,de-C-terminal lysine], anti-(human T cell receptor germline-encoded variable chain V?6/?10) (human-Mus musculus monoclonal BKM0259 ?1-chain), disulfide with human-Mus muscul

Preferred Name

English

humanized immunoglobulin G1-kappa anti-(human T cell receptor germline-encoded variable chain V?6/?10) monomer disulfide bridged to human interleukin 2 (IL-2, T-cell growth factor) ((C<sup>125</sup>>A)-variant fused via (G4S)2 peptide linker to immunoglo

Common Name

English

invikafusp alfa [INN]

Common Name

English

gamma 1 heavy chain (1-447) [VH (Homo sapiens IGHV1-3*01 -(IGHD) -IGHJ4*01, CDR-Kabat [5.17.10] (31-35.50-66.99-108)) (1-119) -Homo sapiens IGHG1*03 (CH1 (120-217), hinge (218-232), CH2 N299>A (233-342), CH3 Y<sup>351</sup>>C, T<sup>368</sup>>S, L<sup>37

Common Name

English

Code System Code Type Description

CAS

2894138-60-2

Created by admin on Wed Apr 02 16:47:58 GMT 2025 , Edited by admin on Wed Apr 02 16:47:58 GMT 2025

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UNIPROT

13065

Created by admin on Wed Apr 02 16:47:58 GMT 2025 , Edited by admin on Wed Apr 02 16:47:58 GMT 2025

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FDA UNII

2E6V84F6FT

Created by admin on Wed Apr 02 16:47:58 GMT 2025 , Edited by admin on Wed Apr 02 16:47:58 GMT 2025

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NCI_THESAURUS

C206925

Created by admin on Wed Apr 02 16:47:58 GMT 2025 , Edited by admin on Wed Apr 02 16:47:58 GMT 2025

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SMS_ID

300000054747

Created by admin on Wed Apr 02 16:47:58 GMT 2025 , Edited by admin on Wed Apr 02 16:47:58 GMT 2025

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From	To
3_134	3_194
3_23	3_88
1_351	2_277
2_290	2_348
2_184	2_244
2_58	2_105
1_369	1_427
1_263	1_323
1_231	2_149
1_228	2_152
1_231	2_152
1_228	2_149
1_222	3_214
1_146	1_202
1_22	1_96

Related Record Type Details


					2E6V84F6FT

Invikafusp Alfa

ACTIVE MOIETY

Comments:

By directly binding to the V?6/V?10 TCR, STAR0602 promotes the activation and expansion of predominantly CD8+ V?6/V?10 T cells, and to a lesser extent CD4+ V?6/V?10 T cells, with augmented cytotoxic function and a central memory-like (TCM) phenotype

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_449] [2_370]	C-TERMINUS			LYSINE	K3Z4F929H6
AMINO ACID REMOVAL	[1_448] [2_369]	C-TERMINUS			Glycine	TE7660XO1C
AMINO_ACID_SUBSTITUTION				Amount:	PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL