TECHNETIUM TC-99M ETHYLENEDICYSTEINE

First approved in 1973

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C8H13N2O4S2.OTc
Molecular Weight	379.33
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of TECHNETIUM TC-99M ETHYLENEDICYSTEINE

Structure Search

SMILES

O=[Tc+3].[O-]C(=O)[C@H](CS)NCCN[C@@H](C[S-])C([O-])=O

InChI

InChIKey=NDEMJVQWTGORQT-USPAICOZSA-K

InChI=1S/C8H16N2O4S2.O.Tc/c11-7(12)5(3-15)9-1-2-10-6(4-16)8(13)14;;/h5-6,9-10,15-16H,1-4H2,(H,11,12)(H,13,14);;/q;;+3/p-3/t5-,6-;;/m0../s1

HIDE SMILES / InChI

Molecular Formula	C8H13N2O4S2
Molecular Weight	265.33
Charge	-3
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	OTc
Molecular Weight	114.0
Charge	3
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.hindawi.com/journals/stni/2014/839369/
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/books/NBK215133/ | https://www.iaea.org/OurWork/ST/NE/NEFW/Technical-Areas/RRS/documents /mo99/WORKINGMATERIALSmo99CM.pdf | https://www.ncbi.nlm.nih.gov/pubmed/27854401

Molybdenum-99 (99Mo, half-life = 66 h) is a parent radionuclide of a diagnostic nuclear isotope. It decays in technetium-99 m (half-life = 6 h), which is used in over 30 million procedures per year around the world. Between 95 and 98 percent of Mo-99 is currently being produced using highly enriched uranium (HEU) targets. Other medical isotopes such as iodine-131 (I-131) and xenon-133 (Xe-133) are by-products of the Mo-99 production process and will be sufficiently available if Mo-99 is available.

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Unknown 2578
bone problems 43 Sources: https://www.drugs.com/cons/osteolite.html	Diagnostic	Approved 8429	OSTEOLITE Approved Use Unknown Launch Date 1977
osteogenesis 43 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/018035s032lbl.pdf	Diagnostic	Approved 8429	DRAXIMAGE MDP-10 Approved Use MDP-25 (Kit for the Preparation of Technetium Tc 99m Medronate) may be used as a bone imaging agent to delineate areas of altered osteogenesis. Launch Date 1978

PubMed

Title	Date	PubMed
Future of low specific activity molybdenum-99/technetium-99m generator.	2012 Oct	22642420

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 09:26:44 GMT 2023` Edited by `admin` on `Sat Dec 16 09:26:44 GMT 2023`
Record UNII	2D30PH7DW4
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TECHNETIUM TC-99M ETHYLENEDICYSTEINE

Common Name

English

TECHNETATE(2-)-99TC, ((N,N'-1,2-ETHANEDIYLBIS(L-CYSTEINATO))(5-)-N,N',S,S')OXO-, DIHYDROGEN, (SP-5-35)-

Systematic Name

English

TECHNETIUM TC 99M ETHYLENEDICYSTEINE

Common Name

English

TECHNETIUM TC 99M-ETHYLENEDICYSTEINE

Common Name

English

TECHNETATE(2-)-99TC, ((N,N'-1,2-ETHANEDIYLBIS(L-CYSTEINATO-.KAPPA.N,.KAPPA.S))(5-))OXO-, DIHYDROGEN, (SP-5-35)-

Common Name

English

Technetium (99mtc)-L,L-ethylenedicysteine [WHO-DD]

Common Name

English

Classification Tree Code System Code

WHO-ATC

V09CA06