Efpegerglucagon

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 05:16:36 GMT 2025` Edited by `admin` on `Wed Apr 02 05:16:36 GMT 2025`
Protein Type	FC FUSION PROTEIN
Protein Sub Type	GLUCAGON-ANALOGUE
Sequence Type	COMPLETE
Record UNII	2CAH3OC0X5
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

HM-15136

Preferred Name

English

Efpegerglucagon

Official Name

English

Human immunoglobulin G4 Fc fragment (h-CH2-CH3-CHS domains [Homo sapiens IGHG4*01 (hinge (1-4), CH2 (5-114), CH3 (115-219), CHS (220-221))]) (1-221), disulfide bridged dimer, produced in Escherichia coli, with one Fc chain conjugated (P <sup>1</sup> ?C<s

Common Name

English

efpegerglucagon [INN]

Common Name

English

HM15136

Code

English

Classification Tree Code System Code

EU-Orphan Drug

EU/3/18/2022

Created by admin on Wed Apr 02 05:16:36 GMT 2025 , Edited by admin on Wed Apr 02 05:16:36 GMT 2025

FDA ORPHAN DRUG

658818

Created by admin on Wed Apr 02 05:16:36 GMT 2025 , Edited by admin on Wed Apr 02 05:16:36 GMT 2025

Code System Code Type Description

NCI_THESAURUS

C203221

Created by admin on Wed Apr 02 05:16:36 GMT 2025 , Edited by admin on Wed Apr 02 05:16:36 GMT 2025

PRIMARY

FDA UNII

2CAH3OC0X5

Created by admin on Wed Apr 02 05:16:36 GMT 2025 , Edited by admin on Wed Apr 02 05:16:36 GMT 2025

PRIMARY

INN

12786

Created by admin on Wed Apr 02 05:16:36 GMT 2025 , Edited by admin on Wed Apr 02 05:16:36 GMT 2025

PRIMARY

SMS_ID

300000011583

Created by admin on Wed Apr 02 05:16:36 GMT 2025 , Edited by admin on Wed Apr 02 05:16:36 GMT 2025

PRIMARY

CAS

2766774-81-4

Created by admin on Wed Apr 02 05:16:36 GMT 2025 , Edited by admin on Wed Apr 02 05:16:36 GMT 2025

PRIMARY

From	To
1_35	1_95
1_141	1_199
2_35	2_95
2_141	2_199
1_3	2_3

Linkage Type	Residue Index
bifunctional maleimide-polyethylene glycol-aldehyde linker	1_1	3_30
N6-Lysine amide	3_16	3_20

Related Record Type Details


					2CAH3OC0X5

Efpegerglucagon

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[3_16] [3_20]	SITE_SPECIFIC			N<sup>6</sup>-L-?-Glutamyl-L-lysine	O19B8F457C
AMINO_ACID_SUBSTITUTION	[1_1] [3_30]	SITE_SPECIFIC			PROLYL PEG-230 CYSTEINE LINKER	OW3Z3MHO4K
AMINO_ACID_SUBSTITUTION	[3_2]	SITE_SPECIFIC			.ALPHA.-AMINOISOBUTYRIC ACID	1E7ZW41IQU

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL