Denikitug

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 11:51:48 GMT 2025` Edited by `admin` on `Wed Apr 02 11:51:48 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1\|KAPPA
Sequence Type	COMPLETE
Record UNII	2C6JX7UEN2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Denikitug (immunoglobulin G1-kappa, anti-[Homo sapiens CCR8 (C-C motif chemokine receptor 8, CKR-L1, CDw198)])

Preferred Name

English

Denikitug

Official Name

English

Immunoglobulin G1, anti-(human CC chemokine receptor CCR8) (human-Mus musculus monoclonal MO12155MEV ?1-chain), disulfide with human-Mus musculus monoclonal MO12155MEV ?-chain, dimer

Common Name

English

denikitug [INN]

Common Name

English

H-gamma1 heavy chain (1-451) [VH Musmus/Homsap (Mus musculus IGHV10-1*02 (90.9%) -(IGHD) -IGHJ1*01 (82.4%) A120>Q (113)/Homo sapiens IGHV3-73*01 (90.0%) -(IGHD) -IGHJ3*01 (92.9%) M123>T (116), CDR-IMGT [8.10.12] (26-33.51-60.99-110)) (1-121) -Homo sapien

Common Name

English

Code System Code Type Description

INN

12950

Created by admin on Wed Apr 02 11:51:48 GMT 2025 , Edited by admin on Wed Apr 02 11:51:48 GMT 2025

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FDA UNII

2C6JX7UEN2

Created by admin on Wed Apr 02 11:51:48 GMT 2025 , Edited by admin on Wed Apr 02 11:51:48 GMT 2025

PRIMARY

SMS_ID

300000048062

Created by admin on Wed Apr 02 11:51:48 GMT 2025 , Edited by admin on Wed Apr 02 11:51:48 GMT 2025

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NCI_THESAURUS

C206899

Created by admin on Wed Apr 02 11:51:48 GMT 2025 , Edited by admin on Wed Apr 02 11:51:48 GMT 2025

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CAS

2865822-82-6

Created by admin on Wed Apr 02 11:51:48 GMT 2025 , Edited by admin on Wed Apr 02 11:51:48 GMT 2025

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From	To
1_22	1_98
2_22	2_98
2_148	2_204
2_224	4_219
2_265	2_325
1_148	1_204
2_371	2_429
3_23	3_93
3_139	3_199
4_23	4_93
4_139	4_199
1_224	3_219
1_230	2_230
1_233	2_233
1_265	1_325
1_371	1_429

Glycosylation Type

MAMMALIAN, AFUCOSYLATED

Glycosylation Link Type	Site
N	1_301
N	2_301

Related Record Type Details


					2C6JX7UEN2

Denikitug

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION				Amount:	PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_450] [1_451] [2_450] [2_451]	C-TERMINUS		Amount:	GLYCYL-L-LYSINE	SC93X84LZ9
AMINO ACID REMOVAL	[1_451] [2_451]	C-TERMINUS		Amount:	LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL