CYM-9484

Details

Stereochemistry	ACHIRAL
Molecular Formula	C27H31N3O3S2
Molecular Weight	509.683
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C)S(=O)(=O)C1=CC=C(NC(=S)N2CCC(CC2)C(O)(C3=CC=CC=C3)C4=CC=CC=C4)C=C1

InChI

InChIKey=VAUKHARIAMDAGF-UHFFFAOYSA-N

InChI=1S/C27H31N3O3S2/c1-29(2)35(32,33)25-15-13-24(14-16-25)28-26(34)30-19-17-23(18-20-30)27(31,21-9-5-3-6-10-21)22-11-7-4-8-12-22/h3-16,23,31H,17-20H2,1-2H3,(H,28,34)

HIDE SMILES / InChI

Molecular Formula	C27H31N3O3S2
Molecular Weight	509.683
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22607676

CYM 9484 is a highly potent and selective small molecule neuropeptide Y Y2 receptor antagonist

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Neuropeptide Y receptor type 2 4 Target ID: CHEMBL4018 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22607676	Antagonist 2849		19.0 nM [IC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

PubMed

Title	Date	PubMed
Ligands of the neuropeptide Y Y2 receptor.	2014-01-15	24365162
Synthesis and SAR of selective small molecule neuropeptide Y Y2 receptor antagonists.	2012-06-15	22607676

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:34:45 GMT 2025` Edited by `admin` on `Mon Mar 31 22:34:45 GMT 2025`
Record UNII	2C52X44WTF
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CYM-9484

Code

English

HY-107735

Preferred Name

English

N-(4-(DIMETHYLSULFAMOYL)PHENYL)-4-(HYDROXY(DIPHENYL)METHYL)PIPERIDINE-1-CARBOTHIOAMIDE

Systematic Name

English

N-(4-((DIMETHYLAMINO)SULFONYL)PHENYL)-4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINECARBOTHIOAMIDE

Systematic Name

English

1-PIPERIDINECARBOTHIOAMIDE, N-(4-((DIMETHYLAMINO)SULFONYL)PHENYL)-4-(HYDROXYDIPHENYLMETHYL)-

Systematic Name

English

CYM 9484

Code

English

Code System Code Type Description

CAS

1383478-94-1

Created by admin on Mon Mar 31 22:34:45 GMT 2025 , Edited by admin on Mon Mar 31 22:34:45 GMT 2025

PRIMARY

FDA UNII

2C52X44WTF

Created by admin on Mon Mar 31 22:34:45 GMT 2025 , Edited by admin on Mon Mar 31 22:34:45 GMT 2025

PRIMARY

PUBCHEM

66561564

Created by admin on Mon Mar 31 22:34:45 GMT 2025 , Edited by admin on Mon Mar 31 22:34:45 GMT 2025

PRIMARY

Related Record Type Details


					2C52X44WTF

CYM-9484

ACTIVE MOIETY

Amount:

Details

SMILES

InChI

DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/22607676

Originator

Approval Year

Targets

Conditions

PubMed

Sample Use Guides

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22607676