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Details

Stereochemistry ACHIRAL
Molecular Formula C27H31N3O3S2
Molecular Weight 509.683
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CYM-9484

SMILES

CN(C)S(=O)(=O)C1=CC=C(NC(=S)N2CCC(CC2)C(O)(C3=CC=CC=C3)C4=CC=CC=C4)C=C1

InChI

InChIKey=VAUKHARIAMDAGF-UHFFFAOYSA-N
InChI=1S/C27H31N3O3S2/c1-29(2)35(32,33)25-15-13-24(14-16-25)28-26(34)30-19-17-23(18-20-30)27(31,21-9-5-3-6-10-21)22-11-7-4-8-12-22/h3-16,23,31H,17-20H2,1-2H3,(H,28,34)

HIDE SMILES / InChI
Molecular Formula C27H31N3O3S2
Molecular Weight 509.683
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

CYM 9484 is a highly potent and selective small molecule neuropeptide Y Y2 receptor antagonist

Originator

Scripps Research Institute
9
Curator's Comment: Mittapalli et al., 2012. The Scripps Research Institute

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Antagonist
2778
 19.0 nM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Synthesis and SAR of selective small molecule neuropeptide Y Y2 receptor antagonists.
2012 Jun 15
Ligands of the neuropeptide Y Y2 receptor.
2014 Jan 15

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Dec 16 09:13:23 GMT 2023
Edited
by admin
on Sat Dec 16 09:13:23 GMT 2023
Record UNII
2C52X44WTF
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CYM-9484
Code English
N-(4-(DIMETHYLSULFAMOYL)PHENYL)-4-(HYDROXY(DIPHENYL)METHYL)PIPERIDINE-1-CARBOTHIOAMIDE
Systematic Name English
N-(4-((DIMETHYLAMINO)SULFONYL)PHENYL)-4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINECARBOTHIOAMIDE
Systematic Name English
HY-107735
Code English
1-PIPERIDINECARBOTHIOAMIDE, N-(4-((DIMETHYLAMINO)SULFONYL)PHENYL)-4-(HYDROXYDIPHENYLMETHYL)-
Systematic Name English
CYM 9484
Code English
Code System Code Type Description
CAS
1383478-94-1
Created by admin on Sat Dec 16 09:13:23 GMT 2023 , Edited by admin on Sat Dec 16 09:13:23 GMT 2023
PRIMARY
FDA UNII
2C52X44WTF
Created by admin on Sat Dec 16 09:13:23 GMT 2023 , Edited by admin on Sat Dec 16 09:13:23 GMT 2023
PRIMARY
PUBCHEM
66561564
Created by admin on Sat Dec 16 09:13:23 GMT 2023 , Edited by admin on Sat Dec 16 09:13:23 GMT 2023
PRIMARY
Related Record Type Details
Structure of CYM-9484
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