Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C23H30N2O2.C2H6O3S |
| Molecular Weight | 476.629 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCS(O)(=O)=O.CCOC(=O)C1(CCN(CCCNC2=CC=CC=C2)CC1)C3=CC=CC=C3
InChI
InChIKey=PRERKVDQJAYTGE-UHFFFAOYSA-N
InChI=1S/C23H30N2O2.C2H6O3S/c1-2-27-22(26)23(20-10-5-3-6-11-20)14-18-25(19-15-23)17-9-16-24-21-12-7-4-8-13-21;1-2-6(3,4)5/h3-8,10-13,24H,2,9,14-19H2,1H3;2H2,1H3,(H,3,4,5)
| Molecular Formula | C23H30N2O2 |
| Molecular Weight | 366.4965 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C2H6O3S |
| Molecular Weight | 110.132 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Piminodine is an analog of pethidine. It was used in medicine for obstetric analgesia and in dental procedures briefly during the 1960s and 1970s, but has largely fallen out of clinical use. Piminodine produces analgesia, sedation and euphoria and has typical side effects associated with opioids, including potentially serious respiratory depression, which can be life-threatening. Piminodine was more potent than desipramine and protriptyline under similar conditions. Compared to meperidine, piminodine is more potent and gives smoother duration. Piminodine can be addictive. Piminodine is currently a Schedule II controlled substance in the United States.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Electronic-topological study of the structure-activity relationships in a series of piperidine morphinomimetics. | 2002-08 |
|
| Investigation of narcotics and antitussives using drug discrimination techniques. | 1979-11 |
|
| Effect of narcotic analgesics on the striatal homovanillic acid content in mice; relation to antinociceptive effect. | 1976-02 |
|
| Radioimmunoassay for anileridine, meperidine and other N-substituted phenylpiperidine carboxylic acid esters. | 1975-10 |
|
| [New anti-curare and analeptic drug, Pimadin, and its use in anesthesia]. | 1973-07-01 |
|
| The effect of narcotic analgesics on the uptake of 5-hydroxytryptamine and (-)-metaraminol by blood platelets. | 1973-04 |
|
| ANALGESIA IN MYOCARDIAL INFARCTION: DOUBLE-BLIND COMPARISON OF PIMINODINE AND MORPHINE. | 1965-05 |
|
| Intravenous Alvodine. A clinical evalution. | 1963-05-01 |
|
| The intravenous use of a new analgesic agent, piminodine in office urologic operative procedures. | 1962-07-01 |
|
| Piminodine as an adjunct to anesthesia. | 1962-03 |
|
| A clinical study and comparison of analgesic drugs Alvodine, WIN 14,265-2 and WIN 14,465-2 with meperidine. | 1962-01-01 |
|
| A comparison of the pharmacology of two potent analgesic agents, piminodine (Win 14,098-2) and Win 13,797, with morphine and meperidine. | 1961-05 |
|
| The analgesic potency of piminodine (alvodine). | 1960-08 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 17:35:59 GMT 2025
by
admin
on
Mon Mar 31 17:35:59 GMT 2025
|
| Record UNII |
2C29WCQ951
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Preferred Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
|
NCI_THESAURUS |
C67413
Created by
admin on Mon Mar 31 17:35:59 GMT 2025 , Edited by admin on Mon Mar 31 17:35:59 GMT 2025
|
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
7081-52-9
Created by
admin on Mon Mar 31 17:35:59 GMT 2025 , Edited by admin on Mon Mar 31 17:35:59 GMT 2025
|
PRIMARY | |||
|
3039186
Created by
admin on Mon Mar 31 17:35:59 GMT 2025 , Edited by admin on Mon Mar 31 17:35:59 GMT 2025
|
PRIMARY | |||
|
C80987
Created by
admin on Mon Mar 31 17:35:59 GMT 2025 , Edited by admin on Mon Mar 31 17:35:59 GMT 2025
|
PRIMARY | |||
|
m1226
Created by
admin on Mon Mar 31 17:35:59 GMT 2025 , Edited by admin on Mon Mar 31 17:35:59 GMT 2025
|
PRIMARY | Merck Index | ||
|
2C29WCQ951
Created by
admin on Mon Mar 31 17:35:59 GMT 2025 , Edited by admin on Mon Mar 31 17:35:59 GMT 2025
|
PRIMARY | |||
|
DTXSID60221072
Created by
admin on Mon Mar 31 17:35:59 GMT 2025 , Edited by admin on Mon Mar 31 17:35:59 GMT 2025
|
PRIMARY | |||
|
CHEMBL2110995
Created by
admin on Mon Mar 31 17:35:59 GMT 2025 , Edited by admin on Mon Mar 31 17:35:59 GMT 2025
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
PARENT -> SALT/SOLVATE |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
ACTIVE MOIETY |