Details
Stereochemistry | ACHIRAL |
Molecular Formula | C23H30N2O2.C2H6O3S |
Molecular Weight | 476.629 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCS(O)(=O)=O.CCOC(=O)C1(CCN(CCCNC2=CC=CC=C2)CC1)C3=CC=CC=C3
InChI
InChIKey=PRERKVDQJAYTGE-UHFFFAOYSA-N
InChI=1S/C23H30N2O2.C2H6O3S/c1-2-27-22(26)23(20-10-5-3-6-11-20)14-18-25(19-15-23)17-9-16-24-21-12-7-4-8-13-21;1-2-6(3,4)5/h3-8,10-13,24H,2,9,14-19H2,1H3;2H2,1H3,(H,3,4,5)
Molecular Formula | C23H30N2O2 |
Molecular Weight | 366.4965 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C2H6O3S |
Molecular Weight | 110.132 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Piminodine is an analog of pethidine. It was used in medicine for obstetric analgesia and in dental procedures briefly during the 1960s and 1970s, but has largely fallen out of clinical use. Piminodine produces analgesia, sedation and euphoria and has typical side effects associated with opioids, including potentially serious respiratory depression, which can be life-threatening. Piminodine was more potent than desipramine and protriptyline under similar conditions. Compared to meperidine, piminodine is more potent and gives smoother duration. Piminodine can be addictive. Piminodine is currently a Schedule II controlled substance in the United States.
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
The intravenous use of a new analgesic agent, piminodine in office urologic operative procedures. | 1962 Jul-Aug |
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Piminodine as an adjunct to anesthesia. | 1962 Mar |
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Intravenous Alvodine. A clinical evalution. | 1963 May-Jun |
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ANALGESIA IN MYOCARDIAL INFARCTION: DOUBLE-BLIND COMPARISON OF PIMINODINE AND MORPHINE. | 1965 May |
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The effect of narcotic analgesics on the uptake of 5-hydroxytryptamine and (-)-metaraminol by blood platelets. | 1973 Apr |
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Radioimmunoassay for anileridine, meperidine and other N-substituted phenylpiperidine carboxylic acid esters. | 1975 Oct |
|
Effect of narcotic analgesics on the striatal homovanillic acid content in mice; relation to antinociceptive effect. | 1976 Feb |
|
Investigation of narcotics and antitussives using drug discrimination techniques. | 1979 Nov |
|
Electronic-topological study of the structure-activity relationships in a series of piperidine morphinomimetics. | 2002 Aug |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14449347
Single dose - 5 mg
Route of Administration:
Intravenous
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:01:56 GMT 2023
by
admin
on
Fri Dec 15 15:01:56 GMT 2023
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Record UNII |
2C29WCQ951
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Record Status |
Validated (UNII)
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Record Version |
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-
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NCI_THESAURUS |
C67413
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7081-52-9
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3039186
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C80987
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m1226
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PRIMARY | Merck Index | ||
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2C29WCQ951
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DTXSID60221072
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CHEMBL2110995
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