U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C20H19F3N2O4
Molecular Weight 408.3711
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SARAKALIM

SMILES

CC(=O)N(O)CC1=C(N2C=CC=CC2=O)C3=C(OC1(C)C)C=CC(=C3)C(F)(F)F

InChI

InChIKey=FXRJKZVWFJSKGI-UHFFFAOYSA-N
InChI=1S/C20H19F3N2O4/c1-12(26)25(28)11-15-18(24-9-5-4-6-17(24)27)14-10-13(20(21,22)23)7-8-16(14)29-19(15,2)3/h4-10,28H,11H2,1-3H3

HIDE SMILES / InChI

Molecular Formula C20H19F3N2O4
Molecular Weight 408.3711
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Sarakalim (previously known as RS 91309) was developed by Roche Bioscience as a putative ATP-sensitive K+ (KATP) channel opener. Sarakalim was studied for the treatment of asthma, However, this study was discontinued.

Originator

Approval Year

PubMed

Substance Class Chemical
Record UNII
2BY2U8GO3M
Record Status Validated (UNII)
Record Version