SARAKALIM

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H19F3N2O4
Molecular Weight	408.3711
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(=O)N(O)CC1=C(N2C=CC=CC2=O)C3=C(OC1(C)C)C=CC(=C3)C(F)(F)F

InChI

InChIKey=FXRJKZVWFJSKGI-UHFFFAOYSA-N

InChI=1S/C20H19F3N2O4/c1-12(26)25(28)11-15-18(24-9-5-4-6-17(24)27)14-10-13(20(21,22)23)7-8-16(14)29-19(15,2)3/h4-10,28H,11H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C20H19F3N2O4
Molecular Weight	408.3711
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9605570 | https://adisinsight.springer.com/drugs/800006475

Sarakalim (previously known as RS 91309) was developed by Roche Bioscience as a putative ATP-sensitive K+ (KATP) channel opener. Sarakalim was studied for the treatment of asthma, However, this study was discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Neuroregulation of mucus secretion by opioid receptors and K(ATP) and BK(Ca) channels in ferret trachea in vitro.	1998 Apr	9605570

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:15:43 GMT 2023` Edited by `admin` on `Fri Dec 15 16:15:43 GMT 2023`
Record UNII	2BY2U8GO3M
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SARAKALIM

Official Name

English

sarakalim [INN]

Common Name

English

RS-91309

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C270