IFABOTUZUMAB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 16:20:46 GMT 2025` Edited by `admin` on `Tue Apr 01 16:20:46 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED
Sequence Type	COMPLETE
Record UNII	2BN89552WP
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

IFABOTUZUMAB

Official Name

English

FIBATUZUMAB

Preferred Name

English

IMMUNOGLOBULIN G1, ANTI-(HUMAN EPHA RECEPTOR EPHA3) (HUMAN MONOCLONAL KB004 HEAVY CHAIN), DISULFIDE WITH HUMAN MONOCLONAL KB004 .KAPPA.-CHAIN, DIMER

Common Name

English

IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENS EPHA3(EPHRIN RECEPTOR A3, EPH RECEPTOR A3, EPHRIN TYPE-A RECEPTOR 3, TYROSINE PROTEIN KINASE TYR04, TYROSINE-PROTEIN KINASE RECEPTOR REK4, ETK, ETK1, HEK, HEK4)), HUMANIZED MONOCLONAL ANTIBODY

Common Name

English

ifabotuzumab [INN]

Common Name

English

Ifabotuzumab [WHO-DD]

Common Name

English

Code System Code Type Description

SMS_ID

100000174558

Created by admin on Tue Apr 01 16:20:46 GMT 2025 , Edited by admin on Tue Apr 01 16:20:46 GMT 2025

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CAS

1234137-51-9

Created by admin on Tue Apr 01 16:20:46 GMT 2025 , Edited by admin on Tue Apr 01 16:20:46 GMT 2025

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INN

10149

Created by admin on Tue Apr 01 16:20:46 GMT 2025 , Edited by admin on Tue Apr 01 16:20:46 GMT 2025

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FDA UNII

2BN89552WP

Created by admin on Tue Apr 01 16:20:46 GMT 2025 , Edited by admin on Tue Apr 01 16:20:46 GMT 2025

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USAN

DE-43

Created by admin on Tue Apr 01 16:20:46 GMT 2025 , Edited by admin on Tue Apr 01 16:20:46 GMT 2025

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NCI_THESAURUS

C116629

Created by admin on Tue Apr 01 16:20:46 GMT 2025 , Edited by admin on Tue Apr 01 16:20:46 GMT 2025

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From	To
1_22	1_96
1_145	1_201
1_262	1_322
1_368	1_426
2_22	2_96
2_145	2_201
2_262	2_322
2_368	2_426
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_221	3_214
2_221	4_214
1_227	2_227
1_230	2_230

Glycosylation Type

MAMMALIAN, AFUCOSYLATED

Glycosylation Link Type	Site
N	1_298
N	2_298

Related Record Type Details


					13U1W2G8EZ

EPHRIN TYPE-A RECEPTOR 3

TARGET->LIGAND

Comments:

EphA3 is an oncofetal antigen with restricted tissue expression, the development of a targeted agent holds promise. Four mechanisms of cell killing have been described: direct induction of apoptosis, activation of antibody-dependent cell-mediated cytotoxicity (ADCC), disruption of tumor vasculature and inhibition of survival signaling from the marrow microenvironment.

Amount:

Related Record Type Details


					2BN89552WP

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL