Approval Year
Substance Class |
Protein
Created
by
admin
on
Edited
Sat Dec 16 11:19:22 GMT 2023
by
admin
on
Sat Dec 16 11:19:22 GMT 2023
|
Protein Type | MONOCLONAL ANTIBODY |
Protein Sub Type | IGG1 |
Sequence Origin | HUMANIZED |
Sequence Type | COMPLETE |
Record UNII |
2BN89552WP
|
Record Status |
Validated (UNII)
|
Record Version |
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-
Download
Name | Type | Language | ||
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Official Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Official Name | English | ||
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Common Name | English | ||
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Common Name | English |
Code System | Code | Type | Description | ||
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1234137-51-9
Created by
admin on Sat Dec 16 11:19:22 GMT 2023 , Edited by admin on Sat Dec 16 11:19:22 GMT 2023
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PRIMARY | |||
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10149
Created by
admin on Sat Dec 16 11:19:22 GMT 2023 , Edited by admin on Sat Dec 16 11:19:22 GMT 2023
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PRIMARY | |||
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2BN89552WP
Created by
admin on Sat Dec 16 11:19:22 GMT 2023 , Edited by admin on Sat Dec 16 11:19:22 GMT 2023
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PRIMARY | |||
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DE-43
Created by
admin on Sat Dec 16 11:19:22 GMT 2023 , Edited by admin on Sat Dec 16 11:19:22 GMT 2023
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PRIMARY | |||
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C116629
Created by
admin on Sat Dec 16 11:19:22 GMT 2023 , Edited by admin on Sat Dec 16 11:19:22 GMT 2023
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PRIMARY |
From | To |
---|---|
1_22 | 1_96 |
1_145 | 1_201 |
1_262 | 1_322 |
1_368 | 1_426 |
2_22 | 2_96 |
2_145 | 2_201 |
2_262 | 2_322 |
2_368 | 2_426 |
3_23 | 3_88 |
3_134 | 3_194 |
4_23 | 4_88 |
4_134 | 4_194 |
1_221 | 3_214 |
2_221 | 4_214 |
1_227 | 2_227 |
1_230 | 2_230 |
Glycosylation Type | MAMMALIAN, AFUCOSYLATED |
Glycosylation Link Type | Site |
---|---|
N | 1_298 |
N | 2_298 |
Related Record | Type | Details | ||
---|---|---|---|---|
|
TARGET->LIGAND |
EphA3 is an oncofetal antigen with restricted tissue expression, the development of a targeted agent holds promise. Four mechanisms of cell killing have been described: direct induction of apoptosis, activation of antibody-dependent cell-mediated cytotoxicity (ADCC), disruption of tumor vasculature and inhibition of survival signaling from the marrow microenvironment.
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Related Record | Type | Details | ||
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ACTIVE MOIETY |
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Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
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Molecular Formula | CHEMICAL |
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||||
MOL_WEIGHT:NUMBER(CALCULATED) | CHEMICAL |
|