TESNATILIMAB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 23:00:55 GMT 2025` Edited by `admin` on `Tue Apr 01 23:00:55 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	2B860WP9F0
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

JNJ-64304500

Preferred Name

English

TESNATILIMAB

Official Name

English

NN-8555

Code

English

TESNATILIMAB [USAN]

Common Name

English

IPH-2301

Code

English

IMMUNOGLOBULIN G4 (223-PROLINE), ANTI-(HUMAN NKG2D RECEPTOR) (HUMAN MONOCLONAL JNJ-64304500 .GAMMA.4-CHAIN), DISULFIDE WITH HUMAN MONOCLONAL JNJ-64304500 LIGHT CHAIN, DIMER

Common Name

English

NNC142-0002 (HUMAN IGG4 ANTI-NKG2D MONOCLONAL ANTIBODY)

Common Name

English

IMMUNOGLOBULIN G4-KAPPA, ANTI-(HOMO SAPIENS KLRK1 (KILLER CELL LECTIN LIKE RECEPTOR K1, NKG2D, KLR, NKG2-D, CD314)), HOMO SAPIENS MONOCLONAL ANTIBODY;GAMMA4 HEAVY CHAIN HOMO SAPIENS (1-442) (VH (HOMO SAPIENS IGHV4-59*01 (93.8%)-(IGHD)-IGHJ3*02 (93.8%)) C

Common Name

English

NNC-0142-0000-0002

Code

English

NNC142-0002

Code

English

JNJ-4500

Code

English

tesnatilimab [INN]

Common Name

English

NN8555

Code

English

Code System Code Type Description

CAS

2242758-08-1

Created by admin on Tue Apr 01 23:00:55 GMT 2025 , Edited by admin on Tue Apr 01 23:00:55 GMT 2025

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NCI_THESAURUS

C175864

Created by admin on Tue Apr 01 23:00:55 GMT 2025 , Edited by admin on Tue Apr 01 23:00:55 GMT 2025

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INN

11249

Created by admin on Tue Apr 01 23:00:55 GMT 2025 , Edited by admin on Tue Apr 01 23:00:55 GMT 2025

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USAN

JK-31

Created by admin on Tue Apr 01 23:00:55 GMT 2025 , Edited by admin on Tue Apr 01 23:00:55 GMT 2025

PRIMARY

SMS_ID

300000022131

Created by admin on Tue Apr 01 23:00:55 GMT 2025 , Edited by admin on Tue Apr 01 23:00:55 GMT 2025

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FDA UNII

2B860WP9F0

Created by admin on Tue Apr 01 23:00:55 GMT 2025 , Edited by admin on Tue Apr 01 23:00:55 GMT 2025

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From	To
1_22	1_95
2_22	2_95
2_129	4_215
2_142	2_198
2_256	2_316
1_129	3_215
2_362	2_420
3_23	3_89
3_135	3_195
4_23	4_89
4_135	4_195
1_142	1_198
1_221	2_221
1_224	2_224
1_256	1_316
1_362	1_420

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_292
N	2_292

Related Record Type Details


					4UID1C8AE2

NKG2-D TYPE II INTEGRAL MEMBRANE PROTEIN

TARGET -> INHIBITOR

Related Record Type Details


					2B860WP9F0

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS		Amount:	PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_442] [2_442]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL