Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C10H12O2 |
| Molecular Weight | 164.2011 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC(\C=C/C)=CC=C1O
InChI
InChIKey=BJIOGJUNALELMI-ARJAWSKDSA-N
InChI=1S/C10H12O2/c1-3-4-8-5-6-9(11)10(7-8)12-2/h3-7,11H,1-2H3/b4-3-
| Molecular Formula | C10H12O2 |
| Molecular Weight | 164.2011 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Optical Activity | NONE |
DescriptionSources: http://www.ema.europa.eu/docs/en_GB/document_library/Maximum_Residue_Limits_-_Report/2011/05/WC500106362.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/15606655Curator's Comment: description was created based on several sources, including
https://link.springer.com/article/10.1007/s00044-015-1486-6 | https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/isoeugenol_508.pdf | https://www.ncbi.nlm.nih.gov/pubmed/21995306
Sources: http://www.ema.europa.eu/docs/en_GB/document_library/Maximum_Residue_Limits_-_Report/2011/05/WC500106362.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/15606655
Curator's Comment: description was created based on several sources, including
https://link.springer.com/article/10.1007/s00044-015-1486-6 | https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/isoeugenol_508.pdf | https://www.ncbi.nlm.nih.gov/pubmed/21995306
(E)-Isoeugenol is crystalline while compound with spice clove type odor. The melting point of E-isoeugenol is 33°C. E-Isoeugenol has been shown to cause contact and allergic dermatitis in humans. Positive skin patch tests in numerous individuals have confirmed the sensitizing ability of isoeugenol.
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL3816 |
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Target ID: CHEMBL2169736 |
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Target ID: CHEMBL2231 |
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Target ID: CHEMBL6007 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Diagnostic | TRUE Test Approved UseUnknown |
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| Diagnostic | TRUE Test Approved UseFragrance mix is composed of eight substances, including isoeugenol (approximately 15 ug). |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Liquid chromatographic separation and fluorometric determination of cis- and trans-isoeugenol in perfumes, colognes, and toilet waters. | 1988 Jul-Aug |
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| Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: effect on NF-kappaB, AP-1, JNK, MAPKK and apoptosis. | 2000 Jun 8 |
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| Structure-activity relationships for a large diverse set of natural, synthetic, and environmental estrogens. | 2001 Mar |
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| Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor. | 2003 Oct |
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| An odorant derivative as an antagonist for an olfactory receptor. | 2004 Nov |
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| Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. | 2006 Nov |
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| Impact of the arylhydrocarbon receptor on eugenol- and isoeugenol-induced cell cycle arrest in human immortalized keratinocytes (HaCaT). | 2006 Sep |
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| Isoeugenol suppression of inducible nitric oxide synthase expression is mediated by down-regulation of NF-kappaB, ERK1/2, and p38 kinase. | 2007 Dec 8 |
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| Do anesthetics and sampling strategies affect transcription analysis of fish tissues? | 2007 Jun 8 |
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| Chemicals with weak skin sensitizing properties can be identified using low-density microarrays on immature dendritic cells. | 2007 Nov 1 |
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| Suppression of interleukin-2 gene expression by isoeugenol is mediated through down-regulation of NF-AT and NF-kappaB. | 2007 Sep |
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| Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds. | 2010 Sep |
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| A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells. | 2010 Sep |
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| Identification of PDL-1 as a novel biomarker of sensitizer exposure in dendritic-like cells. | 2010 Sep |
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| The intra- and inter-laboratory reproducibility and predictivity of the KeratinoSens assay to predict skin sensitizers in vitro: results of a ring-study in five laboratories. | 2011 Apr |
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| Active transport of contact allergens in human monocyte-derived dendritic cells is mediated by multidrug resistance related proteins. | 2011 Apr 15 |
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| An in vitro test to screen skin sensitizers using a stable THP-1-derived IL-8 reporter cell line, THP-G8. | 2011 Dec |
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| The mouse eugenol odorant receptor: structural and functional plasticity of a broadly tuned odorant binding pocket. | 2011 Feb 8 |
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| Impact of eugenol and isoeugenol on AhR translocation, target gene expression, and proliferation in human HaCaT keratinocytes. | 2012 |
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| Isoeugenol destabilizes IL-8 mRNA expression in THP-1 cells through induction of the negative regulator of mRNA stability tristetraprolin. | 2012 Feb |
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| B cell increases and ex vivo IL-2 production as secondary endpoints for the detection of sensitizers in non-radioisotopic local lymph node assay using flow cytometry. | 2012 Mar 25 |
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| NCTC 2544 and IL-18 production: a tool for the identification of contact allergens. | 2013 Apr |
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| Development of a new in vitro skin sensitization assay (Epidermal Sensitization Assay; EpiSensA) using reconstructed human epidermis. | 2013 Dec |
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| Differentiation of skin sensitizers from irritant chemicals by interleukin-1α and macrophage inflammatory protein-2 in murine keratinocytes. | 2013 Jan 10 |
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| Development of an in vitro dendritic cell-based test for skin sensitizer identification. | 2013 Mar 18 |
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| In vitro activity of natural phenolic compounds against fluconazole-resistant Candida species: a quantitative structure-activity relationship analysis. | 2014 Apr |
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| Chemical allergens stimulate human epidermal keratinocytes to produce lymphangiogenic vascular endothelial growth factor. | 2015 Mar 1 |
Sample Use Guides
Isoeugenol is effective at low concentrations of 10 to 20 mg/L corresponding to active ingredient concentrations of 5 to 10 mg/L.
Route of Administration:
Other
| Substance Class |
Chemical
Created
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admin
on
Edited
Fri Dec 15 17:01:12 GMT 2023
by
admin
on
Fri Dec 15 17:01:12 GMT 2023
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| Record UNII |
2A4KEV8DNH
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| Record Status |
Validated (UNII)
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