U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C13H10N2O5
Molecular Weight 274.2289
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 5-HYDROXYTHALIDOMIDE

SMILES

OC1=CC2=C(C=C1)C(=O)N(C3CCC(=O)NC3=O)C2=O

InChI

InChIKey=LJBQRRQTZUJWRC-UHFFFAOYSA-N
InChI=1S/C13H10N2O5/c16-6-1-2-7-8(5-6)13(20)15(12(7)19)9-3-4-10(17)14-11(9)18/h1-2,5,9,16H,3-4H2,(H,14,17,18)

HIDE SMILES / InChI

Molecular Formula C13H10N2O5
Molecular Weight 274.2289
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Approval Year

PubMed

PubMed

TitleDatePubMed
Human liver microsomal cytochrome P450 3A enzymes involved in thalidomide 5-hydroxylation and formation of a glutathione conjugate.
2010 Jun 21
Human cytochrome P450 oxidation of 5-hydroxythalidomide and pomalidomide, an amino analogue of thalidomide.
2014 Jan 21
Patents
Substance Class Chemical
Created
by admin
on Tue Mar 06 15:19:07 UTC 2018
Edited
by admin
on Tue Mar 06 15:19:07 UTC 2018
Record UNII
29V976C3CJ
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
5-HYDROXYTHALIDOMIDE
Common Name English
PHTHALIMIDE, N-(2,6-DIOXO-3-PIPERIDYL)-4-HYDROXY-
Systematic Name English
5-HYDROXY THALIDOMIDE, (+/-)-
Common Name English
1H-ISOINDOLE-1,3(2H)-DIONE, 2-(2,6-DIOXO-3-PIPERIDINYL)-5-HYDROXY-
Systematic Name English
5-HYDROXY THALIDOMIDE
Common Name English
Code System Code Type Description
PUBCHEM
5743568
Created by admin on Tue Mar 06 15:19:07 UTC 2018 , Edited by admin on Tue Mar 06 15:19:07 UTC 2018
PRIMARY
CAS
64567-60-8
Created by admin on Tue Mar 06 15:19:07 UTC 2018 , Edited by admin on Tue Mar 06 15:19:07 UTC 2018
PRIMARY
Related Record Type Details
PARENT -> METABOLITE