SULFISOMIDINE SODIUM

US Previously Marketed

First approved in 1951

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H13N4O2S.Na
Molecular Weight	300.312
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].CC1=NC(C)=NC([N-]S(=O)(=O)C2=CC=C(N)C=C2)=C1

InChI

InChIKey=XTXYCJOBMKKQOW-UHFFFAOYSA-N

InChI=1S/C12H13N4O2S.Na/c1-8-7-12(15-9(2)14-8)16-19(17,18)11-5-3-10(13)4-6-11;/h3-7H,13H2,1-2H3;/q-1;+1

HIDE SMILES / InChI

Molecular Formula	C12H14N4O2S
Molecular Weight	278.33
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.tabletwise.com/medicine/sulphasomidine

Sulfisomidine (INN), also known as sulphasomidine (BAN until 2003), is a sulfonamide antibacterial. It’s used in the treatment, control, prevention, and improvement of the following conditions and symptoms: Lower urinary tract infections; Meningococcal meningitis; Streptococcal pharyngitis; Gum infection; Bacillary dysentery.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
specific fungi 2 Target ID: specific fungi Sources: http://www.tabletwise.com/medicine/sulphasomidine	Inhibitor 8297

Conditions

Condition	Modality	Highest Phase	Product
Lower urinary tract infections 4 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7051761	Curative	Approved 8429	Unknown Approved Use Unknown
Meningococcal meningitis 2 Sources: http://www.tabletwise.com/medicine/sulphasomidine	Curative	Approved 8429	Unknown Approved Use Unknown
Streptococcal pharyngitis 4 Sources: http://www.tabletwise.com/medicine/sulphasomidine	Curative	Approved 8429	Unknown Approved Use Unknown
Bacillary dysentery 3 Sources: http://www.tabletwise.com/medicine/sulphasomidine	Curative	Approved 8429	Unknown Approved Use Unknown
Gum infection 2 Sources: http://www.tabletwise.com/medicine/sulphasomidine	Curative	Approved 8429	Unknown Approved Use Unknown

Sourcing

Vendor/Aggregator	ID	URL
ABI Chem	AC1MT0US
BioSynth	J-015595	https://www.biosynth.com/en/products/all-products/products/J-015595.html
LGC Standards	DRE-C17000405	https://www.lgcstandards.com/US/en/p/DRE-C17000405
PubChem	3543157	https://pubchem.ncbi.nlm.nih.gov/compound/3543157

PubMed

Title	Date	PubMed
Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs.	1995 Aug	7486915
[Drugs and breastfeeding].	2002 Apr-Jun	12426458
Identification of the 'wrong' active pharmaceutical ingredient in a counterfeit Halfan drug product using accurate mass electrospray ionisation mass spectrometry, accurate mass tandem mass spectrometry and liquid chromatography/mass spectrometry.	2003	12539187
In-vitro antifungal activities of sulfa drugs against clinical isolates of Aspergillus and Cryptococcus species.	2007	17287722

Patents

Sample Use Guides

In Vivo Use Guide

2 g twice daily

Route of Administration: Oral

In Vitro Use Guide

The monotherapy of S suis infections with sulfonamides (SULFISOMIDINE was one of them) should not be encouraged because the MIC50 of all sulfonamides investigated was greater than 32 micrograms/ml. The MIC50 of the sulfonamides against B bronchiseptica ranged from 0.5 to 8 micrograms/ml, against P multocida from 2 to 32 micrograms/ml, and against H pleuropneumoniae from 8 to 64 micrograms/ml.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 01:36:20 UTC 2023` Edited by `admin` on `Sat Dec 16 01:36:20 UTC 2023`
Record UNII	296707F7DU
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SULFISOMIDINE SODIUM

Common Name

English

SULFISOMIDINE, SODIUM

Common Name

English

Sulfisomidine sodium [WHO-DD]

Common Name

English

SULFISOMIDINE SODIUM [JAN]

Common Name

English

Code System Code Type Description

SMS_ID

100000142305