TRICHLOROETHYLENE

US Previously Marketed

First marketed in 1935

Details

Stereochemistry	ACHIRAL
Molecular Formula	C2HCl3
Molecular Weight	131.388
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ClC=C(Cl)Cl

InChI

InChIKey=XSTXAVWGXDQKEL-UHFFFAOYSA-N

InChI=1S/C2HCl3/c3-1-2(4)5/h1H

HIDE SMILES / InChI

Molecular Formula	C2HCl3
Molecular Weight	131.388
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.niehs.nih.gov/health/materials/tce_508.pdf | https://www.ncbi.nlm.nih.gov/pubmed/26983615 | https://www.ncbi.nlm.nih.gov/pubmed/27465103

Trichloroethylene (or TCE), a synthetic chemical that does not occur naturally in the environment. TCE is used to make chemicals. Additionally, it is used for spot removal in dry cleaning operations. TCE is the most common organic contaminant in groundwater. It was revealed that the compound was a human carcinogen that caused liver cancer, kidney cancer, and non-Hodgkin's lymphoma (NHL).

Approval Year

Doses

Dose	Population	Adverse events
500 mL single, oral Overdose Dose: 500 mL Route: oral Route: single Dose: 500 mL Sources: https://pubmed.ncbi.nlm.nih.gov/19003597	unhealthy, 47 years Health Status: unhealthy Age Group: 47 years Sex: F Sources: https://pubmed.ncbi.nlm.nih.gov/19003597	Other AEs: Abdominal compartment syndrome... Other AEs: Abdominal compartment syndrome (grade 5) Sources: https://pubmed.ncbi.nlm.nih.gov/19003597

AEs

AE	Significance	Dose	Population
Abdominal compartment syndrome	grade 5	500 mL single, oral Overdose Dose: 500 mL Route: oral Route: single Dose: 500 mL Sources: https://pubmed.ncbi.nlm.nih.gov/19003597	unhealthy, 47 years Health Status: unhealthy Age Group: 47 years Sex: F Sources: https://pubmed.ncbi.nlm.nih.gov/19003597

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
substrate 1946

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
CYP2E1 1060	CYP2E1 729 CYP1A1 389 CYP1A2 1197

Drug as perpetrator

Target	Modality	Activity	Metabolite	Clinical evidence
CYP2E1 1146	inhibitor 4027 Sources: https://pubmed.ncbi.nlm.nih.gov/9041682/	yes [Inhibition 2000 uM]

Drug as victim

Target	Modality	Activity
CYP2E1 729	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/9070354/	major
CYP1A1 389	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/9070354/	minor
CYP1A2 1197	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/9070354/	minor
CYP3A4 1946	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/9070354/	minor

Sourcing

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B4-0908	http://www.3bsc.com/index/pro_info.php?id=18756
3B Scientific (Wuhan) Corp	3B4-0909	http://www.3bsc.com/index/pro_info.php?id=18757
3B Scientific (Wuhan) Corp	3B4-0910	http://www.3bsc.com/index/pro_info.php?id=18758
3B Scientific (Wuhan) Corp	3B4-3140	http://www.3bsc.com/index/pro_info.php?id=77772
AA Blocks	AA003UXW	https://www.aablocks.com/goods/Goods/detail?id=AA003UXW
abcr GmbH	AB142992	http://www.abcr.com/shop/en/AB142992
abcr GmbH	AB171463	http://www.abcr.com/shop/en/AB171463
abcr GmbH	AB204085	http://www.abcr.com/shop/en/AB204085
abcr GmbH	AB208943	http://www.abcr.com/shop/en/AB208943
abcr GmbH	AB210144	http://www.abcr.com/shop/en/AB210144
Acadechem	ACDS-027588	http://www.acadechemical.com/product/102287
Achemica	ACMC-1BMG7	http://www.achemica.com/prodinfo/?id=59395
Achemtek	0104-018057	http://www.achemtek.com/79-01-6
Acros Organics	AC158310025	https://www.fishersci.com/shop/products/trichloroethylene-99-extra-pure-stabilized-acros-organics-1/AC158310025
Acros Organics	AC158310250	https://www.fishersci.com/shop/products/trichloroethylene-99-extra-pure-stabilized-acros-organics/AC158310250
Acros Organics	AC421520025	https://www.fishersci.com/shop/products/trichloroethylene-99-6-acs-reagent-stabilized-acros-organics/AC421520025
Acros Organics	AC421525000	https://www.fishersci.com/shop/products/trichloroethylene-99-6-acs-reagent-stabilized-acros-organics-1/AC421525000
Alfa Aesar	19401	https://www.alfa.com/en/catalog/019401/
Alfa Aesar	39744	https://www.alfa.com/en/catalog/039744/
Alfa Aesar	41894	https://www.alfa.com/en/catalog/041894/
Alfa Aesar	41963	https://www.alfa.com/en/catalog/041963/
Alfa Aesar	43487	https://www.alfa.com/en/catalog/043487/
Alfa Chemistry	ACM79016	https://materials.alfachemic.com/product/ethylene-trichloride-cas-79-01-6-339882.html
Angene	AGN-PC-07A5H2	http://www.angenechemical.com/productshow/AGN-PC-07A5H2.html
Anward	ANW-42318	http://www.anward.com/pro_result/29959
Avantor Inc	101223-856	https://us.vwr.com/store/catalog/product.jsp?catalog_number=101223-856
Avantor Inc	101225-498	https://us.vwr.com/store/catalog/product.jsp?catalog_number=101225-498
Avantor Inc	101225-972	https://us.vwr.com/store/catalog/product.jsp?catalog_number=101225-972
Avantor Inc	101226-734	https://us.vwr.com/store/catalog/product.jsp?catalog_number=101226-734
Avantor Inc	75835-958	https://us.vwr.com/store/product/21998657/usp-60-467-62-singles-restek
BioSynth	J-504494	https://www.biosynth.com/en/products/all-products/products/J-504494.html
BOC Sciences	93952-00-2	https://www.bocsci.com/trichloroethylene-13c2-cas-93952-00-2-item-87590.html
ChemMol	49416775	http://www.chemmol.com/chemmol/49416775.html
ChemMol	99153468	http://www.chemmol.com/chemmol/99153468.html
Chemspace	CSSB00000210349	https://chem-space.com/CSSB00000210349
Clearsynth	CS-T-86775	https://www.clearsynth.com/en/CST86775.html
Huateng Pharma	F94983	https://en.huatengsci.com/products/intermediates/
LGC Standards	DRE-C17739300	https://www.lgcstandards.com/US/en/p/DRE-C17739300
LGC Standards	DRE-GA09011112ME	https://www.lgcstandards.com/US/en/p/DRE-GA09011112ME
LGC Standards	DRE-L17739300ME	https://www.lgcstandards.com/US/en/p/DRE-L17739300ME
LGC Standards	DRE-XA17739300ME	https://www.lgcstandards.com/US/en/p/DRE-XA17739300ME
LGC Standards	DRE-Y17739300ME	https://www.lgcstandards.com/US/en/p/DRE-Y17739300ME
mcule	MCULE-3945953656	https://mcule.com/MCULE-3945953656/
MuseChem	M024356	https://www.musechem.com/product/M024356.html
Oakwood	95063	http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=132507&ExtHyperLink=1
Parchem	17275	http://www.parchem.com/chemical-supplier-distributor/Trichloroethylene-Reagent-Grade-ACS-007275.aspx
Renno Tech	RL05049	http://www.rennotech.com/product_show.asp?id=5298
Sigma-Aldrich	133124_ALDRICH	https://www.sigmaaldrich.com/catalog/product/aldrich/133124?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	24254_SIGALD	https://www.sigmaaldrich.com/catalog/product/sigald/24254?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	251402_SIGALD	https://www.sigmaaldrich.com/catalog/product/sigald/251402?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	256420_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/256420?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	30-4000_SAJ	https://www.sigmaaldrich.com/catalog/product/saj/304000?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sinfoo Biotech	S011931	http://www.sinfoobiotech.com/product/1015329
Smolecule	S545809	http://www.smolecule.com/products/s545809
THE BioTek	bt-286739	https://www.thebiotek.com/product/inhibitors/bt-286739
Vitas-M Laboratory	STL282732	http://www.request.vitasmlab.com/index.php?option=com_search_stk&Itemid=22&stk=STL282732&?utm_source=pubchem&utm_medium=p_search_link&utm_campaign=pubchem_search&utm_content=pubchem_slink
VladaChem	VL144776	https://www.vladachem.com/product.php?products=79-01-6
VladaChem	VL160737	https://www.vladachem.com/product.php?products=79-01-6

PubMed

Title	Date	PubMed
Reductive dehalogenation of chlorinated ethenes with elemental iron: the role of microorganisms.	2001-09	11487103
Remediation of TCE contaminated soils by in situ EK-Fenton process.	2001-08-17	11489531
Functional analyses of Bph-Tod hybrid dioxygenase, which exhibits high degradation activity toward trichloroethylene.	2001-08-10	11390387
Measurement of Henry's law constant for methyl tert-butyl ether using solid-phase microextraction.	2001-08	11491542
Inverse analyses of transport of chlorinated hydrocarbons subject to sequential transformation reactions.	2001-07-31	11476514
Applications of ultrasound in NAPL remediation: sonochemical degradation of TCE in aqueous surfactant solutions.	2001-07-15	11478257
Trichloroethylene in urine as biological exposure index.	2001-07	11499997
Aerobic degradation of mixtures of tetrachloroethylene, trichloroethylene, dichloroethylenes, and vinyl chloride by toluene-o-xylene monooxygenase of Pseudomonas stutzeri OX1.	2001-07	11499942
In-situ oxidation of trichloroethene by permanganate: effects on porous medium hydraulic properties.	2001-07	11475162
The use of 3M porous polymer extraction discs in assessing protective clothing chemical permeation.	2001-07	11458919
Guar gum reduces trichloroethylene accumulation in the body by reducing TCE absorption and fat tissue mass.	2001-07	11453799
The modelling of trichloroethene photodegradation in Brij 35 surfactant by two-stage reaction.	2001-07	11444302
Anaesthesia in an unusual location.	2001-06	11412206
Microorganisms relevant to bioremediation.	2001-06	11404100
Development of a biobarrier for the remediation of PCE-contaminated aquifer.	2001-06	11368222
Feasibility of using metals to remediate water containing TCE.	2001-06	11368216
A field evaluation of in situ biodegradation of trichloroethylene through methane injection.	2001-06	11358293
Photodegradation of chlorinated hydrocarbons in the presence and absence of dissolved oxygen in water.	2001-06	11337840
In vitro dehalogenation of tetrachloroethylene (PCE) by cell-free extracts of Clostridium bifermentans DPH-1.	2001-06	11333032
Effects of pH on dechlorination of trichloroethylene by zero-valent iron.	2001-05-30	11348735
Radiolytic and thermal dechlorination of organic chlorides adsorbed on molecular sieve 13X.	2001-05-15	11393996
Biologically-enhanced removal of PCE from NAPL source zones.	2001-05-15	11393982
Travel-time based model of bioremediation using circulation wells.	2001-05-09	11341008
Assessment of indigenous reductive dechlorinating potential at a TCE-contaminated site using microcosms, polymerase chain reaction analysis, and site data.	2001-05-01	11355200
In situ anaerobic transformation of trichlorofluoroethene in trichloroethene-contaminated groundwater.	2001-05-01	11355185
"Hepatitic flare", asthenia, peripheral polyneuropathy and diffuse liver steatosis in a hepatitis C virus asymptomatic chronic carrier.	2001-05	11432516
Assessing interaction thresholds for trichloroethylene in combination with tetrachloroethylene and 1,1,1-trichloroethane using gas uptake studies and PBPK modeling.	2001-05	11409535
Determination of chlorinated solvents in exhaled air, urine, and blood of subjects exposed in the workplace using SPME and GC-MS.	2001-05	11409213
Purification, cloning, and sequencing of an enzyme mediating the reductive dechlorination of tetrachloroethylene (PCE) from Clostridium bifermentans DPH-1.	2001-05	11400736
Optimization of an exogenous metabolic activation system for FETAX. I. Post-isolation rat liver microsome mixtures.	2001-05	11360429
An assessment of natural biotransformation of petroleum hydrocarbons and chlorinated solvents at an aquifer plume transect.	2001-05	11351513
A controlled field experiment on groundwater contamination by a multicomponent DNAPL: creation of the emplaced-source and overview of dissolved plume development.	2001-05	11351512
Long-term effects on male reproduction of early exposure to common chemical contaminants in drinking water.	2001-05	11331649
Evaluation of shale and organoclays as sorbent additives for low-permeability soil containment barriers.	2001-04-01	11348096
Wettability changes in trichloroethylene-contaminated sandstone.	2001-04-01	11348094
Variability in carbon isotopic fractionation during biodegradation of chlorinated ethenes: implications for field applications.	2001-03-01	11351533
Errors in TCE analysis.	2001-03	11333195
Transformation of chlorinated aliphatic compounds by ferruginous smectite.	2001-02-15	11349296
Factors affecting humic-nickel complex mediated reduction of trichloroethene in homogeneous aqueous solution.	2001-02-15	11349283
Pd-catalyzed TCE dechlorination in water: effect of [H2](aq) and H2-utilizing competitive solutes on the TCE dechlorination rate and product distribution.	2001-02-15	11349280
Evaluating competitive sorption mechanisms of volatile organic compounds in soils and sediments using polymers and zeolites.	2001-02-01	11351730
Reductive dechlorination of cis-1,2-dichloroethene and vinyl chloride by "Dehalococcoides ethenogenes".	2001-02-01	11351722
Phytotoxicity of chlorinated aliphatics to hybrid poplar (Populus deltoides x nigra DN34).	2001-02	11351440
Adsorption of trichloroethene at the vapor/water interface.	2001-01-15	11347610
Stable carbon isotope evidence for intrinsic bioremediation of tetrachloroethene and trichloroethene at area 6, Dover Air Force Base.	2001-01-15	11347596
Application of spinel-type cobalt chromite as a novel catalyst for combustion of chlorinated organic pollutants.	2001-01-01	11352017
Electrochemical remediation of trichloroethene-contaminated groundwater using palladized iron oxides.	2001	11501315
Alteration of drug kinetics in rats following exposure to trichloroethylene.	2001	11490201
The importance of reliable exposure estimates in deciding whether trichloroethylene can cause kidney cancer.	2001	11414201
Substrate interactions during aerobic biodegradation of methane, ethene, vinyl chloride and 1,2-dichloroethenes.	2001	11379150

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:45:46 GMT 2025` Edited by `admin` on `Mon Mar 31 17:45:46 GMT 2025`
Record UNII	290YE8AR51
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TRICHLOROETHYLENE

Official Name

English

ANAMENTH

Preferred Name

English

TRICHLOROETHYLENE [II]

Common Name

English

TRICHLOROETHYLENE [FCC]

Common Name

English

NARKOSOID

Brand Name

English

trichloroethylene [INN]

Common Name

English

TRICHLOROETHYLENE [MART.]

Common Name

English

1,1,2-TRICHLOROETHYLENE

Systematic Name

English

TRICHLOROETHYLENE [USP-RS]

Common Name

English

TRICHLOROETHYLENE [HSDB]

Common Name

English

TRICHLOROETHENE

Common Name

English

Trichloroethylene [WHO-DD]

Common Name

English

TRICHLOROETHYLENE [MI]

Common Name

English

DENSINFLUAT

Brand Name

English

WESTROSOL

Brand Name

English

TRICHLOROETHYLENE [IARC]

Common Name

English

GERMALGENE

Brand Name

English

Classification Tree Code System Code

CFR

21 CFR 173.290