Vecilmeran

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 20:17:02 UTC 2023` Edited by `admin` on `Sat Dec 16 20:17:02 UTC 2023`
Nucleic Acid Subtype
Record UNII	28PLX9696B
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Vecilmeran

Official Name

English

vecilmeran [INN]

Common Name

English

RNA (recombinant 5′-(m7G-(5′→5′)-ppp-Gm)-capped human immunoglobulin IgE ε-chain signal peptide plus severe acute respiratory syndrome coronavirus 2 spike glycoprotein B.1.1.529.4 and B.1.1.529.5 variant receptor-binding domain plus 5′-and

Common Name

English

messenger RNA (mRNA), 5'-capped, encoding a codon-optimised receptor binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) glycoprotein (Omicron sub-lineages B.1.1.529.4 and B.1.1.529.5; also known as BA.4 and

Common Name

English

Code System Code Type Description

FDA UNII

28PLX9696B

Created by admin on Sat Dec 16 20:17:03 UTC 2023 , Edited by admin on Sat Dec 16 20:17:03 UTC 2023

PRIMARY

CAS

2854349-87-2

Created by admin on Sat Dec 16 20:17:03 UTC 2023 , Edited by admin on Sat Dec 16 20:17:03 UTC 2023

PRIMARY

INN

12895

Created by admin on Sat Dec 16 20:17:03 UTC 2023 , Edited by admin on Sat Dec 16 20:17:03 UTC 2023

PRIMARY

Sugar	Site Range	Site Count
D-Ribose (RNA)	1_1-1_1042	1042 / 1042

Linkage	Site Range	Site Count
Phosphate	1_2-1_1042	1041 / 1041

Related Record Type Details


					K377DQF5WK

Vecilmeran expressed preprotein (receptor binding domain (RBD) of SARS-CoV-2 spike (S) glycoprotein (Omicron sub-lineages B.1.1.529.4 and B.1.1.529.5))

EXPRESSED PROTEIN->VECTOR

Amount:


					B6L4N5Z4GH

SARS-COV2

TARGET ORGANISM->VACCINE ANTIGEN

Amount:


					VYE552K8NY

Vecilmeran expressed receptor binding domain (RBD) of SARS-CoV-2 spike (S) glycoprotein (Omicron sub-lineages B.1.1.529.4 and B.1.1.529.5)

EXPRESSED PROTEIN->VECTOR

Amount:

Related Record Type Details


					28PLX9696B

Vecilmeran

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[1_1]	5'-TERMINUS	G	Amount:	5'-GUANOSINE-M-RNA-CAP-1-3'-PHOSPHATE	T0HQY09X7B

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Human immunoglobulin ε-chain (IgE) signal peptide (SP) coding sequence	NUCLEIC ACID FEATURE

Poly A	NUCLEIC ACID FEATURE

3'UTR	NUCLEIC ACID FEATURE

S-RBD	NUCLEIC ACID FEATURE

5'UTR	NUCLEIC ACID FEATURE