VUTRISIRAN SODIUM

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 14:56:44 GMT 2023` Edited by `admin` on `Sat Dec 16 14:56:44 GMT 2023`
Nucleic Acid Type	OLIGONUCLEOTIDE
Nucleic Acid Subtype
Sequence Type	COMPLETE
Record UNII	28O0WP6Z1P
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

VUTRISIRAN SODIUM

Official Name

English

ALN-TTRSC02

Code

English

ALN-65492 SODIUM

Code

English

Vutrisiran sodium [WHO-DD]

Common Name

English

VUTRISIRAN SODIUM [JAN]

Common Name

English

AMVUTTRA

Brand Name

English

RNA, (Um-sp-(2'-deoxy-2'-fluoro)C-sp-Um-Um-Gm-(2'-deoxy-2'-fluoro)G-UmUm-(2'-deoxy-2'-fluoro)A-Cm-Am-Um-Gm-(2'-deoxy-2'-fluoro)A-Am-(2'-deoxy2'-fluoro)A-Um-Cm-Cm-Cm-Am-sp-Um-sp-Cm), complex with RNA (Um-spGm-sp-Gm-Gm-Am-Um-(2'-deoxy-2'-fluoro)U-Um-(2'-de

Systematic Name

English

VOTRISIRAN SODIUM

Official Name

English

Code System Code Type Description

RXCUI

2605574

Created by admin on Sat Dec 16 14:56:44 GMT 2023 , Edited by admin on Sat Dec 16 14:56:44 GMT 2023

PRIMARY

FDA UNII

28O0WP6Z1P

Created by admin on Sat Dec 16 14:56:44 GMT 2023 , Edited by admin on Sat Dec 16 14:56:44 GMT 2023

PRIMARY

Sugar	Site Range	Site Count
2'-O-Methyl-Ribose	1_1-1_6;1_8;1_12-1_22;2_1;2_3-2_5;2_7-2_8;2_10-2_13;2_15;2_17-2_23	36 / 45
2'-Fluoro-Ribose	1_7;1_9-1_11;2_2;2_6;2_9;2_14;2_16	9 / 45

Linkage	Site Range	Site Count
Sodium Phosporothioate	1_2-1_3;2_2-2_3;2_22-2_23	6 / 43
	1_4-1_22;2_4-2_21	37 / 43

Related Record Type Details


					GB4I2JI8UI

VUTRISIRAN

PARENT -> SALT/SOLVATE

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[1_22]	SITE_SPECIFIC			GIVOSIRAN SODIUM TRIGLYCAN-END GROUP	8142CN1H73

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL