Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C24H29FN2O4 |
| Molecular Weight | 428.4965 |
| Optical Activity | ( + ) |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC(=CC=C1OCCCN2CCC(CC2)C3=NOC4=CC(F)=CC=C34)[C@@H](C)O
InChI
InChIKey=SBKZGLWZGZQVHA-MRXNPFEDSA-N
InChI=1S/C24H29FN2O4/c1-16(28)18-4-7-21(23(14-18)29-2)30-13-3-10-27-11-8-17(9-12-27)24-20-6-5-19(25)15-22(20)31-26-24/h4-7,14-17,28H,3,8-13H2,1-2H3/t16-/m1/s1
| Molecular Formula | C24H29FN2O4 |
| Molecular Weight | 428.4965 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
P-88-8991, (+)- is a metabolite of Iloperidone. It has functional affinity for noradrenergic, dopaminergic and serotoninergic receptors. Humans produce only one enantiomer stereospecifically following administration of Iloperidone. Preclinical studies revealed that P-88-8991, (+)- might be useful for the treatment of psychotic disorders such as schizophrenia and bipolar disorders.
CNS Activity
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL2094251 |
9.2 null [pKi] | ||
Target ID: CHEMBL1916 |
7.7 null [pKi] | ||
Target ID: CHEMBL322 |
8.9 null [pKi] | ||
Target ID: CHEMBL3372 |
7.8 null [pKi] | ||
Target ID: CHEMBL217 |
7.4 null [pKi] |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Unknown Approved UseUnknown |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 01:36:10 GMT 2023
by
admin
on
Sat Dec 16 01:36:10 GMT 2023
|
| Record UNII |
2896I16LBA
|
| Record Status |
Validated (UNII)
|
| Record Version |
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-
Download
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2896I16LBA
Created by
admin on Sat Dec 16 01:36:10 GMT 2023 , Edited by admin on Sat Dec 16 01:36:10 GMT 2023
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501373-87-1
Created by
admin on Sat Dec 16 01:36:10 GMT 2023 , Edited by admin on Sat Dec 16 01:36:10 GMT 2023
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6918698
Created by
admin on Sat Dec 16 01:36:10 GMT 2023 , Edited by admin on Sat Dec 16 01:36:10 GMT 2023
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PRIMARY |