U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C22H24O9
Molecular Weight 432.4206
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 3,5,6,7,8,3',4'-HEPTAMETHPHOXYFLAVONE

SMILES

COC1=CC=C(C=C1OC)C2=C(OC)C(=O)C3=C(O2)C(OC)=C(OC)C(OC)=C3OC

InChI

InChIKey=SSXJHQZOHUYEGD-UHFFFAOYSA-N
InChI=1S/C22H24O9/c1-24-12-9-8-11(10-13(12)25-2)16-19(27-4)15(23)14-17(26-3)20(28-5)22(30-7)21(29-6)18(14)31-16/h8-10H,1-7H3

HIDE SMILES / InChI

Molecular Formula C22H24O9
Molecular Weight 432.4206
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
Cancer chemopreventive activity of 3,5,6,7,8,3',4'-heptamethoxyflavone from the peel of citrus plants.
2001 Feb 10
Immunotoxicity of a standardized citrus polymethoxylated flavone extract.
2001 Nov
Genetic toxicity of a standardized mixture of citrus polymethoxylated flavones.
2002 May
Identification of epoxybergamottin as a CYP3A4 inhibitor in grapefruit peel.
2003 Feb
Effect of flavones on rat brain and lung matrix metalloproteinase activity measured by film in-situ zymography.
2005 Apr
Preparative isolation and purification of polymethoxylated flavones from Tangerine peel using high-speed counter-current chromatography.
2005 Oct 7
Effects of various methoxyflavones on vincristine uptake and multidrug resistance to vincristine in P-gp-overexpressing K562/ADM cells.
2007 Oct
Simultaneous determination of five bioactive flavonoids in pericarpium Citri reticulatae from china by high-performance liquid chromatography with dual wavelength detection.
2009 Aug 12
Flavonoids from the stems of Croton caudatus Geisel. var. tomentosus Hook.
2010 Feb 26
Isolation and identification of polymethoxyflavones from the hybrid Citrus, hallabong.
2010 Sep 8
Patents
Substance Class Chemical
Created
by admin
on Fri Dec 15 18:47:58 UTC 2023
Edited
by admin
on Fri Dec 15 18:47:58 UTC 2023
Record UNII
288R4CAV1V
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
3,5,6,7,8,3',4'-HEPTAMETHPHOXYFLAVONE
Systematic Name English
3-METHOXYNOBILETIN
Common Name English
3',4',3,5,6,7,8-HEPTAMETHOXYFLAVONE
Systematic Name English
FLAVONE, 3,3',4',5,6,7,8-HEPTAMETHOXY-
Systematic Name English
4H-1-BENZOPYRAN-4-ONE, 2-(3,4-DIMETHOXYPHENYL)-3,5,6,7,8-PENTAMETHOXY-
Systematic Name English
3,5,6,7,8,3',4'-HEPTAMETHOXYFLAVONE
Official Name English
2-(3,4-DIMETHOXYPHENYL)-3,5,6,7,8-PENTAMETHOXY-4H-1-BENZOPYRAN-4-ONE
Systematic Name English
3,3',4',5,6,7,8-HEPTAMETHOXYFLAVONE
Systematic Name English
NSC-618928
Code English
Code System Code Type Description
FDA UNII
288R4CAV1V
Created by admin on Fri Dec 15 18:47:58 UTC 2023 , Edited by admin on Fri Dec 15 18:47:58 UTC 2023
PRIMARY
CAS
1178-24-1
Created by admin on Fri Dec 15 18:47:58 UTC 2023 , Edited by admin on Fri Dec 15 18:47:58 UTC 2023
PRIMARY
PUBCHEM
150893
Created by admin on Fri Dec 15 18:47:58 UTC 2023 , Edited by admin on Fri Dec 15 18:47:58 UTC 2023
PRIMARY
EPA CompTox
DTXSID70151912
Created by admin on Fri Dec 15 18:47:58 UTC 2023 , Edited by admin on Fri Dec 15 18:47:58 UTC 2023
PRIMARY
NSC
618928
Created by admin on Fri Dec 15 18:47:58 UTC 2023 , Edited by admin on Fri Dec 15 18:47:58 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> CONSTITUENT ALWAYS PRESENT
64% Cell growth rate of human acute promyelocytic leukemia HL-60 cells at 50 uM of compound vs control
PARENT -> CONSTITUENT ALWAYS PRESENT
44% Cell growth rate of mouse myeloid leukemia M1 cells at 50 uM of compound vs control