Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C21H19BrN4O2.C6H6O3S |
Molecular Weight | 597.48 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OS(=O)(=O)C1=CC=CC=C1.COC(=O)CC[C@@H]2N=C(C3=NC=CC=C3)C4=C(C=CC(Br)=C4)N5C(C)=CN=C25
InChI
InChIKey=QMTKNJZIWGTNTE-LMOVPXPDSA-N
InChI=1S/C21H19BrN4O2.C6H6O3S/c1-13-12-24-21-17(7-9-19(27)28-2)25-20(16-5-3-4-10-23-16)15-11-14(22)6-8-18(15)26(13)21;7-10(8,9)6-4-2-1-3-5-6/h3-6,8,10-12,17H,7,9H2,1-2H3;1-5H,(H,7,8,9)/t17-;/m0./s1
Molecular Formula | C21H19BrN4O2 |
Molecular Weight | 439.305 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Molecular Formula | C6H6O3S |
Molecular Weight | 158.175 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Remimazolam is an intravenous benzodiazepine sedative-hypnotic with rapid onset and offset of action. This compound undergoes organ-independent metabolism to an inactive metabolite. Like other benzodiazepines, remimazolam can be reversed with flumazenil to rapidly terminate sedation and anesthesia. Phase I and II clinical trials have shown that remimazolam is safe and effective when used for procedural sedation. Phase III clinical trials have been completed investigating efficacy and safety in patients undergoing bronchoscopy and colonoscopy. The developer of this drug has suggested that intensive care unit sedation (beyond 24 hours) could be another possible indication for further development, since it is unlikely that prolonged infusions or higher doses of remimazolam would result in accumulation and extended effect.
CNS Activity
Originator
Approval Year
Substance Class |
Chemical
Created
by
admin
on
Edited
Tue Oct 22 15:36:00 UTC 2019
by
admin
on
Tue Oct 22 15:36:00 UTC 2019
|
Record UNII |
280XQ6482H
|
Record Status |
Validated (UNII)
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Record Version |
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-
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1001415-66-2
Created by
admin on Tue Oct 22 15:36:00 UTC 2019 , Edited by admin on Tue Oct 22 15:36:00 UTC 2019
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23658607
Created by
admin on Tue Oct 22 15:36:00 UTC 2019 , Edited by admin on Tue Oct 22 15:36:00 UTC 2019
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PRIMARY |
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PARENT -> SALT/SOLVATE | |||
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ACTIVE MOIETY |