ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMBER 1

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 12:39:58 GMT 2025` Edited by `admin` on `Wed Apr 02 12:39:58 GMT 2025`
Protein Type	ENZYME
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	27VB43Q7CV
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMBER 1

Common Name

English

E-NPP 1

Preferred Name

English

ENPP1

Common Name

English

PHOSPHODIESTERASE I/NUCLEOTIDE PYROPHOSPHATASE 1

Common Name

English

MEMBRANE COMPONENT CHROMOSOME 6 SURFACE MARKER 1

Common Name

English

PLASMA-CELL MEMBRANE GLYCOPROTEIN PC-1

Common Name

English

Code System Code Type Description

PHAROS

P22413

Created by admin on Wed Apr 02 12:39:58 GMT 2025 , Edited by admin on Wed Apr 02 12:39:58 GMT 2025

PRIMARY

CAS

1354626-64-4

Created by admin on Wed Apr 02 12:39:58 GMT 2025 , Edited by admin on Wed Apr 02 12:39:58 GMT 2025

NO STRUCTURE GIVEN

UNIPROT

P22413

Created by admin on Wed Apr 02 12:39:58 GMT 2025 , Edited by admin on Wed Apr 02 12:39:58 GMT 2025

PRIMARY

EC (ENZYME CLASS)

EC 3.6.1.9

Created by admin on Wed Apr 02 12:39:58 GMT 2025 , Edited by admin on Wed Apr 02 12:39:58 GMT 2025

PRIMARY

EC (ENZYME CLASS)

EC 3.1.4.1

Created by admin on Wed Apr 02 12:39:58 GMT 2025 , Edited by admin on Wed Apr 02 12:39:58 GMT 2025

PRIMARY

FDA UNII

27VB43Q7CV

Created by admin on Wed Apr 02 12:39:58 GMT 2025 , Edited by admin on Wed Apr 02 12:39:58 GMT 2025

PRIMARY

From	To
1_108	1_122
1_112	1_140
1_120	1_133
1_126	1_132
1_149	1_166
1_154	1_184
1_164	1_177
1_170	1_176
1_195	1_241
1_203	1_415
1_431	1_530
1_480	1_868
1_614	1_672
1_626	1_726
1_628	1_711
1_838	1_848
2_108	2_122
2_112	2_140
2_120	2_133
2_126	2_132
2_149	2_166
2_154	2_184
2_164	2_177
2_170	2_176
2_195	2_241
2_203	2_415
2_431	2_530
2_480	2_868
2_614	2_672
2_626	2_726
2_628	2_711
2_838	2_848

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_179
N	1_285
N	1_341
N	1_477
N	1_585
N	1_643
N	1_700
N	1_731
N	1_748
N	2_179
N	2_285
N	2_341
N	2_477
N	2_585
N	2_643
N	2_700
N	2_731
N	2_748

Related Record Type Details


					W3AJ7GG533

(2-(1-(8-methoxyquinazolin-4-yl)piperidin-4-yl)ethyl)phosphonic acid

INHIBITOR -> TARGET

Amount:


					8ZH1P9LXW1

INZ-701

ENZYME REPLACEMENT->TARGET

Amount:


					N8SGU55BWE

1H-1,4-Diazepine-1-sulfonamide, 4-(6,7-dimethoxy-4-quinazolinyl)hexahydro-

INHIBITOR -> TARGET

Interaction Type:

PRECLINICAL

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
METAL_BINDING	[1_800] [1_802] [1_804] [1_806] [1_808]	SITE_SPECIFIC			CALCIUM CATION	2M83C4R6ZB
METAL_BINDING	[1_218] [1_256] [1_423] [1_424]	SITE_SPECIFIC			ZINC CATION	13S1S8SF37
METAL_BINDING	[2_376] [2_380] [2_535]	SITE_SPECIFIC			ZINC CATION	13S1S8SF37
METAL_BINDING	[2_800] [2_802] [2_804] [2_806] [2_808]	SITE_SPECIFIC			CALCIUM CATION	2M83C4R6ZB
METAL_BINDING	[1_376] [1_380] [1_535]	SITE_SPECIFIC			ZINC CATION	13S1S8SF37
METAL_BINDING	[2_218] [2_256] [2_423] [2_424]	SITE_SPECIFIC			ZINC CATION	13S1S8SF37
AMINO_ACID_SUBSTITUTION	[1_256] [2_256]	SITE_SPECIFIC			THREONINE PHOSPHATE	3L4WX7B1EI

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL