ASTEGOLIMAB

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National Institutes of Health Divider Arrow

NCATS

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 21:14:48 GMT 2025` Edited by `admin` on `Tue Apr 01 21:14:48 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG2
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	27TW751DTH
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

MSTT1041A

Preferred Name

English

ASTEGOLIMAB

Official Name

English

IMMUNOGLOBULIN G2, ANTI-(HUMAN INTERLEUKIN-33 RECEPTOR) (HUMAN MONOCLONAL MSTT1041A .GAMMA.2-CHAIN), DISULFIDE WITH HUMAN MONOCLONAL MSTT1041A .KAPPA.-CHAIN, DIMER

Common Name

English

RG6149

Code

English

AMG282

Code

English

AMG-282

Code

English

RG-6149

Code

English

MSTT-1041A

Code

English

IMMUNOGLOBULIN GX-KAPPA, ANTI-(HOMO SAPIENS INTERLEUKIN-1 RECEPTOR-LIKE 1 (PROTEIN ST2, EC=3.2.2.6)) HOMO SAPIENS MONOCLONAL ANTIBODY.GAMMA.2 HEAVY CHAIN HOMO SAPIENS (1-447) (HOMO SAPIENS VH (IGHV5-51*01 (96%) (IGHD)-IGHJ6*01 (94%)) (8.8.14) (1-121)-HOM

Common Name

English

RO-7187807

Code

English

ASTEGOLIMAB [USAN]

Common Name

English

astegolimab [INN]

Common Name

English

HUMAN MAB THAT INHIBITS THE BINDING OF IL-33 (NF-HEV) TO IL-1 RECEPTOR-LIKE 1

Common Name

English

Astegolimab [WHO-DD]

Common Name

English

Code System Code Type Description

INN

11067

Created by admin on Tue Apr 01 21:14:48 GMT 2025 , Edited by admin on Tue Apr 01 21:14:48 GMT 2025

PRIMARY

CAS

2173054-79-8

Created by admin on Tue Apr 01 21:14:48 GMT 2025 , Edited by admin on Tue Apr 01 21:14:48 GMT 2025

PRIMARY

SMS_ID

300000038062

Created by admin on Tue Apr 01 21:14:48 GMT 2025 , Edited by admin on Tue Apr 01 21:14:48 GMT 2025

PRIMARY

USAN

HI-116

Created by admin on Tue Apr 01 21:14:48 GMT 2025 , Edited by admin on Tue Apr 01 21:14:48 GMT 2025

PRIMARY

NCI_THESAURUS

C171824

Created by admin on Tue Apr 01 21:14:48 GMT 2025 , Edited by admin on Tue Apr 01 21:14:48 GMT 2025

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FDA UNII

27TW751DTH

Created by admin on Tue Apr 01 21:14:48 GMT 2025 , Edited by admin on Tue Apr 01 21:14:48 GMT 2025

PRIMARY

From	To
1_22	1_96
1_135	3_214
1_148	1_204
1_223	2_223
1_224	2_224
1_227	2_227
1_230	2_230
1_261	1_321
1_367	1_425
2_22	2_96
2_135	4_214
2_148	2_204
2_261	2_321
2_367	2_425
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_297
N	2_297

Related Record Type Details


					OW2974S604

INTERLEUKIN-1 RECEPTOR-LIKE 1

TARGET -> INHIBITOR

Comments:

anti-ST2 human IgG2? monoclonal antibody that blocks IL-33 binding to IL-1 family receptor ST2

Related Record Type Details


					27TW751DTH

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL		C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL