ISOAMINILE CITRATE

Details

Stereochemistry	MIXED
Molecular Formula	C16H24N2.C6H8O7
Molecular Weight	436.4987
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)CC(O)(CC(O)=O)C(O)=O.CC(C)C(CC(C)N(C)C)(C#N)C1=CC=CC=C1

InChI

InChIKey=ZXASMEUEMIIBDZ-UHFFFAOYSA-N

InChI=1S/C16H24N2.C6H8O7/c1-13(2)16(12-17,11-14(3)18(4)5)15-9-7-6-8-10-15;7-3(8)1-6(13,5(11)12)2-4(9)10/h6-10,13-14H,11H2,1-5H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

HIDE SMILES / InChI

Molecular Formula	C16H24N2
Molecular Weight	244.3752
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	C6H8O7
Molecular Weight	192.1235
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://home.intekom.com/pharm/hmr/peraconx.html

Isoaminile is a cough suppressant that acts by influencing the cough centre.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Cough 106 Sources: http://home.intekom.com/pharm/hmr/peraconx.html	Primary		Approved 8583	PERACON Approved Use For the alleviation of cough.

Doses

Dose	Population	Adverse events
40 mg 3 times / day multiple, oral Studied dose Dose: 40 mg, 3 times / day Route: oral Route: multiple Dose: 40 mg, 3 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/6749701/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: unknown Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/6749701/	Sources: https://pubmed.ncbi.nlm.nih.gov/6749701/
750 mg single, intravenous Overdose Dose: 750 mg Route: intravenous Route: single Dose: 750 mg Sources: https://pubmed.ncbi.nlm.nih.gov/518294/	healthy Health Status: healthy Sex: M Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/518294/	Other AEs: Nystagmus... Other AEs: Nystagmus (1 pt) Sources: https://pubmed.ncbi.nlm.nih.gov/518294/

AEs

AE	Significance	Dose	Population
Nystagmus	1 pt	750 mg single, intravenous Overdose Dose: 750 mg Route: intravenous Route: single Dose: 750 mg Sources: https://pubmed.ncbi.nlm.nih.gov/518294/	healthy Health Status: healthy Sex: M Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/518294/

PubMed

Title	Date	PubMed
A comparative randomized double-blind clinical trial of isoaminile citrate and chlophedianol hydrochloride as antitussive agents.	1982-08	6749701
[Goodpasture's syndrome--rapid remission after early plasmapheresis and high-dose cyclophosphamide therapy (author's transl)].	1982-06-15	7109502
Some cases of acute intoxications from compulsive use of isoaminile.	1979-09	518294
[Drug abuse of isoaminile].	1973-04-30	4733605
Isoaminile as inhibitor of muscarinic and nicotinic ganglionic receptors.	1970	5431771
Isoaminile citrate as a cough suppressant.	1966-03	5905421
[ON THE MORPHINE-LIKE PROPERTIES OF A NEW ANTITUSSIVE (ISOAMINIL; PERACON, MULLATUSS)].	1964-10	14345464
Evaluation of isoaminile citrate as an antitussive.	1962-01-01	13901029
[Further clinical experiences with peracon and peracon expectorant].	1961-11	13909558
[2 Years of experience with peracon in general practice].	1960-05-05	14432226
[Peracon in practice. Experiences with a new kind of antitussive agent].	1959-10-30	13804201
[Clinical comparison of a new antitussive substance (peracon) with codeine & dicodide].	1959-05	13676089
[Experiences with the cough medication peracon].	1958-09	13589509

Sample Use Guides

In Vivo Use Guide

One to two medicine measurefuls (5 to 10 mL) three to four times daily.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:22:05 GMT 2025` Edited by `admin` on `Mon Mar 31 19:22:05 GMT 2025`
Record UNII	27K34XSD46
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

PEROCAN

Preferred Name

English

ISOAMINILE CITRATE

Common Name

English

ISOAMINILE CITRATE [MI]

Common Name

English

.ALPHA.-(2-(DIMETHYLAMINO)PROPYL)-.ALPHA.-(1-METHYLETHYL)BENZENEACETONITRILE CITRATE

Systematic Name

English

ISOAMINILE CITRATE [JAN]

Common Name

English

4-(DIMETHYLAMINO)-2-ISOPROPYL-2-PHENYLVALERONITRILE CITRATE

Systematic Name

English

Isoaminile citrate [WHO-DD]

Common Name

English

ISOAMINILE CITRATE [MART.]

Common Name

English

Code System Code Type Description

CAS

2365-38-0