Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C9H11N5O4 |
| Molecular Weight | 253.2147 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NC1=NC2=C(N=C(C=N2)[C@@H](O)[C@H](O)CO)C(=O)N1
InChI
InChIKey=BMQYVXCPAOLZOK-INEUFUBQSA-N
InChI=1S/C9H11N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h1,4,6,15-17H,2H2,(H3,10,11,13,14,18)/t4-,6-/m1/s1
| Molecular Formula | C9H11N5O4 |
| Molecular Weight | 253.2147 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/1782220 | https://www.drugbank.ca/drugs/DB02385 | https://www.ncbi.nlm.nih.gov/pubmed/5680748
Curator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/1782220 | https://www.drugbank.ca/drugs/DB02385 | https://www.ncbi.nlm.nih.gov/pubmed/5680748
D-(+)-Neopterin (D-monapterin, Monapterin) is a pteridine derivative, naturally found in Dictyostelium discoideum and in the urine of cancer patients.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Reduced pteridine derivatives induce apoptosis in PC12 cells. | 2002-07 |
|
| YKL-40 is elevated in cerebrospinal fluid from patients with purulent meningitis. | 2002-05 |
|
| Serum neopterin and activity of coronary artery disease. | 2002-04-27 |
|
| Pteridine derivatives as modulators of oxidative stress. | 2002-04 |
|
| Immune monitoring in organ transplantation using neopterin. | 2002-04 |
|
| Neopterin as a marker for immune system activation. | 2002-04 |
|
| Inflammatory responses in Ebola virus-infected patients. | 2002-04 |
|
| Thoracoscopy versus thoracotomy: a prospective comparison of trauma and quality of life. | 2002-04 |
|
| Procalcitonin and neopterin as indicators of infection in critically ill patients. | 2002-04 |
|
| Plasma levels of soluble CD27: a simple marker to monitor immune activation during potent antiretroviral therapy in HIV-1-infected subjects. | 2002-03 |
|
| Reaction mechanism of GTP cyclohydrolase I: single turnover experiments using a kinetically competent reaction intermediate. | 2002-02-22 |
|
| Stressful life events and skin diseases: an additional perspective from research on psychosomatic dynamics in systemic lupus erythematosus. | 2002-02-15 |
|
| Screening for tetrahydrobiopterin deficiency among hyperphenylalaninemia patients in Southern China. | 2002-02 |
|
| [Role of pathological delayed-type hypersensitivity in chronic fatigue syndrome: importance of the evaluation of lymphocyte activation by flow cytometry and the measurement of urinary neopterin]. | 2002-02 |
|
| Dopa-responsive dystonia -- the story so far. | 2002-02 |
|
| Local immunostimulation induced by intravesical administration of autologous interferon-gamma-activated macrophages in patients with superficial bladder cancer. | 2002-02 |
|
| Treatment of Crohn's disease with recombinant human interleukin 10 induces the proinflammatory cytokine interferon gamma. | 2002-02 |
|
| Intraarterial chemotherapy of malignant melanoma metastatic to the liver. | 2002-01-30 |
|
| Relationships between serum markers of monocyte/macrophage activation in type 1 Gaucher's disease. | 2002-01 |
|
| Serum neopterin monitoring and vitamin E-modified, regenerated hemodialyzer membrane influence on biocompatibility. | 2002-01 |
|
| Prolonged intrathecal release of soluble Fas following severe traumatic brain injury in humans. | 2002-01 |
|
| Decreased plasma tetrahydrobiopterin in pregnant women is caused by impaired 6-pyruvoyl tetrahydropterin synthase activity. | 2002-01 |
|
| Factors influencing serum neopterin concentrations in a population of blood donors. | 2002 |
|
| Influence of cytokines tumor necrosis factor-alpha and interferon-gamma on signaling cascades associated with apoptosis in rat PC12 cells. | 2001-12-28 |
|
| Monitoring of immune activation using biochemical changes in a porcine model of cardiac arrest. | 2001-12 |
|
| Secondary prevention with fluvastatin decreases levels of adhesion molecules, neopterin and C-reactive protein. | 2001-12 |
|
| Increased blood-brain barrier permeability in neuro-asymptomatic HIV-1-infected individuals--correlation with cerebrospinal fluid HIV-1 RNA and neopterin levels. | 2001-12 |
|
| Complement binding to erythrocytes is associated with macrophage activation and reduced haemoglobin in Plasmodium falciparum malaria. | 2001-11-15 |
|
| Monocyte function and plasma levels of interleukin-8 in acute ischemic stroke. | 2001-11-15 |
|
| Randomized pilot trial of betaINF1a (Avonex) in patients with inclusion body myositis. | 2001-11-13 |
|
| Chemokines CXCL10 and CCL2: differential involvement in intrathecal inflammation in multiple sclerosis. | 2001-11 |
|
| Aqueous extracts of Crinum latifolium (L.) and Camellia sinensis show immunomodulatory properties in human peripheral blood mononuclear cells. | 2001-11 |
|
| Perioperative treatment with human recombinant interferon-gamma: a randomized double-blind clinical trial. | 2001-11 |
|
| Dehydroepiandrosterone, ageing and immune activation. | 2001-11 |
|
| Low serum levels of CD44, CD44v6, and neopterin indicate immune dysfunction in chronic pancreatitis. | 2001-11 |
|
| Tetrahydrobiopterin deficiencies without hyperphenylalaninemia: diagnosis and genetics of dopa-responsive dystonia and sepiapterin reductase deficiency. | 2001-10-11 |
|
| Biochemical profile and survival in nonagenarians. | 2001-10 |
|
| Neopterin measurement in clinical diagnosis. | 2001-10 |
|
| [Changes in serum neopterin levels in patients after trauma]. | 2001-09 |
|
| Protection of U937 cells from free radical damage by the macrophage synthesized antioxidant 7,8-dihydroneopterin. | 2001-09 |
|
| Drug level monitoring: the next advance in diagnostics. | 2001-08 |
|
| Is hyperhomocysteinemia due to the oxidative depletion of folate rather than to insufficient dietary intake? | 2001-08 |
|
| [The predictive value of serum neopterin for multiple organ dysfunction syndrome in extensively burned patients]. | 2001-06 |
|
| Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder. | 2001-03 |
|
| Cytokines and chronic fatigue syndrome. | 2001-03 |
|
| [Hepatocytes growth factor (HGF), leptin, neopterin serum concentrations in patients with chronic hepatitis C]. | 2001 |
|
| The role of immune activation in endotoxin-induced atherogenesis. | 2001 |
|
| HIV infection and aging: enhanced Interferon- and Tumor Necrosis Factor-alpha production by the CD8+ CD28- T subset. | 2001 |
|
| Clinical utility of selected disease activity markers in patients with systemic lupus erythematosus. | 2001 |
|
| [The influence of daily psychosocial stressors and associated emotions on the dynamic course of urine cortisol and urine neopterin in systemic lupus erythematosus: Experience taken from two "integrative single-case studies"]. | 2001 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 22:50:42 GMT 2025
by
admin
on
Mon Mar 31 22:50:42 GMT 2025
|
| Record UNII |
26C7CRZ5LJ
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Preferred Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
10162-32-0
Created by
admin on Mon Mar 31 22:50:42 GMT 2025 , Edited by admin on Mon Mar 31 22:50:42 GMT 2025
|
PRIMARY | |||
|
26C7CRZ5LJ
Created by
admin on Mon Mar 31 22:50:42 GMT 2025 , Edited by admin on Mon Mar 31 22:50:42 GMT 2025
|
PRIMARY | |||
|
49751
Created by
admin on Mon Mar 31 22:50:42 GMT 2025 , Edited by admin on Mon Mar 31 22:50:42 GMT 2025
|
PRIMARY | |||
|
DB02385
Created by
admin on Mon Mar 31 22:50:42 GMT 2025 , Edited by admin on Mon Mar 31 22:50:42 GMT 2025
|
PRIMARY | |||
|
DTXSID30276498
Created by
admin on Mon Mar 31 22:50:42 GMT 2025 , Edited by admin on Mon Mar 31 22:50:42 GMT 2025
|
PRIMARY | |||
|
m7817
Created by
admin on Mon Mar 31 22:50:42 GMT 2025 , Edited by admin on Mon Mar 31 22:50:42 GMT 2025
|
PRIMARY | Merck Index | ||
|
135460965
Created by
admin on Mon Mar 31 22:50:42 GMT 2025 , Edited by admin on Mon Mar 31 22:50:42 GMT 2025
|
PRIMARY |