ETHACIZINE HYDROCHLORIDE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H27N3O3S.ClH
Molecular Weight	449.994
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CCOC(=O)NC1=CC2=C(SC3=C(C=CC=C3)N2C(=O)CCN(CC)CC)C=C1

InChI

InChIKey=VHNXQKLWIQHSOY-UHFFFAOYSA-N

InChI=1S/C22H27N3O3S.ClH/c1-4-24(5-2)14-13-21(26)25-17-9-7-8-10-19(17)29-20-12-11-16(15-18(20)25)23-22(27)28-6-3;/h7-12,15H,4-6,13-14H2,1-3H3,(H,23,27);1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C22H27N3O3S
Molecular Weight	413.533
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/15798717

Ethacizine (ethacyzine) is a class Ic antiarrhythmic agent, related to moracizine. It is used in Russia and some other Commonwealth of Independent States countries for the treatment of severe and/or refractory ventricular and supraventricular arrhythmias, especially those accompanied by organic heart disease. It is also indicated as a treatment of refractory tachycardia associated with Wolff–Parkinson–White syndrome.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
cardiac muscle cell action potential 2 Target ID: GO:0086001 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2538064	Inhibitor 8504

Conditions

Condition	Modality	Targets	Highest Phase	Product
Atrial fibrillation 131 Sources: https://www.rlsnet.ru/tn_index_id_5522.htm	Primary		Approved 8583	Ethacyzin Approved Use Unknown
Wolff-Parkinson-White syndrome 5 Sources: https://www.rlsnet.ru/tn_index_id_5522.htm	Primary		Approved 8583	Ethacyzin Approved Use Unknown

C_max

Value	Dose	Co-administered	Analyte	Population
63.7 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/32146624/	100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered:		ETHACIZINE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

AUC

Value	Dose	Co-administered	Analyte	Population
571.6 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/32146624/	100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered:		ETHACIZINE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
6.7 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/32146624/	100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered:		ETHACIZINE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

PubMed

Title	Date	PubMed
[Atrial fibrillation: choice of the method of pharmacological cardioversion].	2005	15798717
Ethacizin metabolism in humans.	1989-07	2773511

Patents

Sample Use Guides

In Vivo Use Guide

The initial dose is 50 mg (1 table) 2-3 times a day. In case of insufficient clinical effect, the dose is increased (under compulsory ECG monitoring) to 50 mg 4 times a day (200 mg) or 100 mg 3 times daily (300 mg).

Route of Administration: Oral

In Vitro Use Guide

Ethacizine applied in the concentration range between 1 X 10(-7) and 1 X 10(-5) g/ml decreased the rate of action potential growth (Vmax) of the mammal myocardium. Inhibition of the Vmax was accompanied by the diminution of the force of contraction which involved two phases. Ethacizine also decreased the overshoot of slow response action potential with the time constant similar to that in the first rapid phase of force reduction.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 20:59:00 GMT 2025` Edited by `admin` on `Mon Mar 31 20:59:00 GMT 2025`
Record UNII	260059T81O
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CARBAMIC ACID, (10-(3-(DIETHYLAMINO)-1-OXOPROPYL)-10H-PHENOTHIAZIN-2-YL)-, ETHYL ESTER, MONOHYDROCHLORIDE

Preferred Name

English

ETHACIZINE HYDROCHLORIDE

Common Name

English

ETHYL 10-(3-(DIETHYLAMINO)PROPIONYL)PHENOTHIAZINE-2-CARBAMATE HYDROCHLORIDE

Common Name

English

Ethacizine hydrochloride [WHO-DD]

Common Name

English

ETHACIZIN HYDROCHLORIDE

Common Name

English

ETACIZIN HYDROCHLORIDE

Common Name

English

Code System Code Type Description

FDA UNII

260059T81O