Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C21H25N5O2 |
| Molecular Weight | 379.4555 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC=CN=C1CCCCNC2=NC(=O)C(CC3=CC=C(C)N=C3)=CN2
InChI
InChIKey=GJCSPRIRQYWXRW-UHFFFAOYSA-N
InChI=1S/C21H25N5O2/c1-15-8-9-16(13-24-15)12-17-14-25-21(26-20(17)27)23-10-4-3-6-18-19(28-2)7-5-11-22-18/h5,7-9,11,13-14H,3-4,6,10,12H2,1-2H3,(H2,23,25,26,27)
| Molecular Formula | C21H25N5O2 |
| Molecular Weight | 379.4555 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Icotidine (also known as SKF 93319) was developed as histamine H1- and H2-receptor antagonist and possessed antinociception properties. Due to its antagonist activity, was suggested that compound could have therapeutic in some inflammatory skin diseases such as the urticarias and mastocytosis.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Icotidine, an antagonist of histamine at both H1 and H2 receptors. | 1986-03-01 |
|
| Cardiovascular studies with SK&F 93319, an antagonist of histamine at both H1- and H2-receptors. | 1984-10 |
|
| The pharmacokinetics in man of SK&F 93319--a new antagonist of histamine H1 and H2 receptors. | 1984-07 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 17:58:51 GMT 2025
by
admin
on
Mon Mar 31 17:58:51 GMT 2025
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| Record UNII |
25Y9G9575K
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| Record Status |
Validated (UNII)
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| Record Version |
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Preferred Name | English | ||
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NCI_THESAURUS |
C29578
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72108
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71351-79-6
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DTXSID40221555
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U-79
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25Y9G9575K
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CHEMBL145087
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300000051334
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C65881
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
