Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C21H42O4 |
| Molecular Weight | 358.5558 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO
InChI
InChIKey=VBICKXHEKHSIBG-UHFFFAOYSA-N
InChI=1S/C21H42O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(24)25-19-20(23)18-22/h20,22-23H,2-19H2,1H3
| Molecular Formula | C21H42O4 |
| Molecular Weight | 358.5558 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
DescriptionCurator's Comment: Description was created based on several sources, including https://www.ulprospector.com/en/eu/PersonalCare/Detail/1409/75456/Arlacel-165 and
https://books.google.ru/books?id=C4Cr8dHupVsC&pg=PA273&lpg=PA273&dq=MONOSTEARIN+approved&source=bl&ots=3U3S0OCvrn&sig=1aCs8tLlzy0KbTA2_K9ZPuMG1M8&hl=en&sa=X&ved=0ahUKEwjBpvuD_Z3PAhWBKywKHY0oDMs4ChDoAQgpMAU#v=onepage&q=MONOSTEARIN%20approved&f=false, Retrieved from Handbook of Fillers, Extenders, and Diluents
edited by Michael Ash, Irene Ash, p. 273
Curator's Comment: Description was created based on several sources, including https://www.ulprospector.com/en/eu/PersonalCare/Detail/1409/75456/Arlacel-165 and
https://books.google.ru/books?id=C4Cr8dHupVsC&pg=PA273&lpg=PA273&dq=MONOSTEARIN+approved&source=bl&ots=3U3S0OCvrn&sig=1aCs8tLlzy0KbTA2_K9ZPuMG1M8&hl=en&sa=X&ved=0ahUKEwjBpvuD_Z3PAhWBKywKHY0oDMs4ChDoAQgpMAU#v=onepage&q=MONOSTEARIN%20approved&f=false, Retrieved from Handbook of Fillers, Extenders, and Diluents
edited by Michael Ash, Irene Ash, p. 273
Glyceryl 1-stearate (Glycerol monostearate), commonly known as GMS, is an organic molecule used as an emulsifier. GMS is a white, odorless, and sweet-tasting flaky powder that is hygroscopic. It is a glycerol ester of stearicacid. It occurs naturally in the body as a product of the breakdown of fats by pancreatic lipase, and is also found in fatty foods. GMS is a food additive used as a thickening, emulsifying, anti-caking, and preservative agent; an emulsifying agent for oils, waxes, and solvents; a protective coating for hygroscopic powders; a solidifier and control release agent in pharmaceuticals; and a resin lubricant. It is also used in cosmetics and hair care products. Used in antiperspirants and deodorants, baby care, body care, facial care, sun care, conditioners, facial make-up, creams and lotions-skin care, sprayable emulsions, feet, hands and nails, self-tanning, nail grooming and color cosmetics. GMS is largely used in baking preparations to add "body" to the food. It is responsible for giving ice cream and whipped cream its smooth texture. It is sometimes used as an anti-staling agent in bread. Glycerol 1-stearate is affirmed by FDA as GRAS.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL230 Sources: http://www.ncbi.nlm.nih.gov/pubmed/18487046 |
|||
Target ID: CHEMBL3474 Sources: http://www.ncbi.nlm.nih.gov/pubmed/18487046 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Preventing | Fresh Med Solution Approved UseTemporarily protects and helps relieve chapped or cracked skin. Helps protect from the drying effects of wind and cold weather Launch Date2011 |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Lipid Nanocarrier-Mediated Drug Delivery System to Enhance the Oral Bioavailability of Rifabutin. | 2017-04 |
|
| Doxycycline hyclate-loaded bleached shellac in situ forming microparticle for intraperiodontal pocket local delivery. | 2016-10-10 |
|
| Monoglycerides from the brown alga Sargassum sagamianum: Isolation, synthesis, and biological activity. | 2008-06-15 |
Patents
Sample Use Guides
In Vitro Use Guide
Sources: http://www.ncbi.nlm.nih.gov/pubmed/18487046
Glyceryl 1-stearate inhibited 16.5% COX2 at 50 uM
| Substance Class |
Chemical
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