Imdusiran

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NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 10:17:11 GMT 2025` Edited by `admin` on `Wed Apr 02 10:17:11 GMT 2025`
Nucleic Acid Type	siRNA
Sequence Type	COMPLETE
Record UNII	256UZ34AF2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AB-729 FREE ACID

Preferred Name

English

Imdusiran

Official Name

English

IMDUSIRAN [USAN]

Common Name

English

RNA, (Gm-sp-Um-sp-Gm-Cm-(2?-deoxy-2?-fluoro)A-(2?-deoxy-2?-fluoro)C-(2?-deoxy-2?-fluoro)U-Um-Cm-Gm-Cm-Um-Um-Cm-Am-Cm-Am), 3?-[[[rel-(3S,4R)]-1-(9-carboxy-1-oxononyl)-4-(hydroxymethyl)-3,4-dimethyl-3-pyrrolidinyl]methyl hydrogen phosphate], carboxamide wi

Common Name

English

imdusiran [INN]

Common Name

English

[1-(10-{[(S)-1,5-Bis({2-[(3,5-bis{[2-(2-{2-[(2-acetamido-2-deoxy-?-D-galactopyranosyl)oxy]ethoxy}ethoxy)ethyl]carbamoyl}phenyl)amino]-2-oxoethyl}amino)-1,5-dioxopentan-2-yl]amino}-10-oxodecanoyl)-4-(hydroxymethyl)-3,4-dimethylpyrrolidin-3-yl]methyl all-P

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C203134

Created by admin on Wed Apr 02 10:17:11 GMT 2025 , Edited by admin on Wed Apr 02 10:17:11 GMT 2025

PRIMARY

SMS_ID

300000044360

Created by admin on Wed Apr 02 10:17:11 GMT 2025 , Edited by admin on Wed Apr 02 10:17:11 GMT 2025

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FDA UNII

256UZ34AF2

Created by admin on Wed Apr 02 10:17:11 GMT 2025 , Edited by admin on Wed Apr 02 10:17:11 GMT 2025

PRIMARY

CAS

2839476-19-4

Created by admin on Wed Apr 02 10:17:11 GMT 2025 , Edited by admin on Wed Apr 02 10:17:11 GMT 2025

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INN

12975

Created by admin on Wed Apr 02 10:17:11 GMT 2025 , Edited by admin on Wed Apr 02 10:17:11 GMT 2025

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USAN

LM-90

Created by admin on Wed Apr 02 10:17:11 GMT 2025 , Edited by admin on Wed Apr 02 10:17:11 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
2'-Fluoro-Ribose	1_2;1_14;1_16;2_5-2_7	6 / 39
D-Ribose (RNA)	1_22	1 / 39
2'-O-Methyl-Ribose	1_1;1_3-1_13;1_15;1_17-1_21;2_1-2_4;2_8-2_17	32 / 39

Linkage	Site Range	Site Count
Phosphate	1_4-1_19;1_22;2_4-2_17	31 / 37
Phosporothioate	1_2-1_3;1_20-1_21;2_2-2_3	6 / 37

Related Record Type Details


					256UZ34AF2

Imdusiran

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[2_17]	3'-TERMINUS			UNSPECIFIED SUBSTANCE	4abef529 (not in database)