NELTENEXINE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H20Br2N2O2S.ClH
Molecular Weight	524.698
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.O[C@H]1CC[C@@H](CC1)NCC2=C(NC(=O)C3=CC=CS3)C(Br)=CC(Br)=C2

InChI

InChIKey=ZVPWQPVEYLBIFG-SKKCDYJJSA-N

InChI=1S/C18H20Br2N2O2S.ClH/c19-12-8-11(10-21-13-3-5-14(23)6-4-13)17(15(20)9-12)22-18(24)16-2-1-7-25-16;/h1-2,7-9,13-14,21,23H,3-6,10H2,(H,22,24);1H/t13-,14-;

HIDE SMILES / InChI

Molecular Formula	C18H20Br2N2O2S
Molecular Weight	488.237
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/67095919 | https://www.ncbi.nlm.nih.gov/pubmed/11535970 | https://www.drugs.com/international/neltenexine.html

NELTENEXINE, an amide derivative of ambroxol and thiophenecarboxylic acid, is a mucolytic agent. It is an elastase inhibitor used in the treatment of human lung diseases.

Approval Year

PubMed

Title	Date	PubMed
Neltenexine tablets in smoking and non-smoking patients with COPD. A double-blind, randomised, controlled study versus placebo.	2001 Aug	11535971
Oral neltenexine in patients with obstructive airways diseases: an open, randomised, controlled comparison versus sobrerol.	2001 Aug	11535970
Action of neltenexine on anion secretion in human airway epithelia.	2007 May 18	17400191
Over-the-counter (OTC) medications to reduce cough as an adjunct to antibiotics for acute pneumonia in children and adults.	2007 Oct 17	17943884
Pharmacological and non-pharmacological interventions for cough in adults with respiratory and non-respiratory diseases: A systematic review of the literature.	2010 Jul	20385478

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 02:00:18 GMT 2023` Edited by `admin` on `Sat Dec 16 02:00:18 GMT 2023`
Record UNII	25553VXB1O
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NELTENEXINE HYDROCHLORIDE

Common Name

English

PU-163

Code

English

Neltenexine hydrochloride [WHO-DD]

Common Name

English

2-THIOPHENECARBOXAMIDE, N-(2,4-DIBROMO-6-(((4-HYDROXYCYCLOHEXYL)AMINO)METHYL)PHENYL)-, MONOHYDROCHLORIDE, TRANS-

Common Name

English

PU 163

Code

English

2-THIOPHENECARBOXAMIDE, N-(2,4-DIBROMO-6-(((TRANS-4-HYDROXYCYCLOHEXYL)AMINO)METHYL)PHENYL)-, MONOHYDROCHLORIDE

Common Name

English

Code System Code Type Description

CAS

99461-80-0