Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C12H15N3O6 |
| Molecular Weight | 297.264 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O=C1N(C[C@H]2CO2)C(=O)N(C[C@@H]3CO3)C(=O)N1C[C@@H]4CO4
InChI
InChIKey=OUPZKGBUJRBPGC-HLTSFMKQSA-N
InChI=1S/C12H15N3O6/c16-10-13(1-7-4-19-7)11(17)15(3-9-6-21-9)12(18)14(10)2-8-5-20-8/h7-9H,1-6H2/t7-,8-,9+/m1/s1
| Molecular Formula | C12H15N3O6 |
| Molecular Weight | 297.264 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Teroxirone is a triazene triepoxide patented by Shell Internationale Research Maatschappij NV as an antineoplastic agent. Teroxirone alkylates and cross-links DNA, thereby inhibiting DNA replication. Teroxirone has good cytotoxic activity against sublines of P388 and L1210 leukemias resistant to another alkylating agent. In preclinical trials, Teroxirone shows potent antineoplastic activity against murine tumors. In clinical trials, Teroxirone shows good anticancer activity and high rate of adverse events including nausea, vomiting, and myelosuppression.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| A review on plant-derived natural products and their analogs with anti-tumor activity. | 2008-03 |
|
| A novel chip device based on wired capillary packed with high performance polymer-based monolith for HPLC: reproducibility in preparation processes to obtain long columns. | 2008-01 |
|
| Hypersensitivity pneumonitis caused by triglycidyl isocyanurate. | 2004-10 |
|
| Determination of triglycidyl isocyanurate from powder coatings in occupational hygiene samples by gas chromatography with mass spectrometric detection. | 2004-08 |
|
| Dermal exposure to dry powder spray paints using PXRF and the method of Dirichlet tesselations. | 2004-04 |
|
| Selective amino acids changes in the medial and lateral preoptic area in the formalin test in rats. | 2004 |
|
| Worker exposure to 1,3,5-triglycidyl isocyanurate (TGIC) in powder paint coating operations. | 2003-03 |
|
| Cross-reactivity among epoxy acrylates and bisphenol F epoxy resins in patients with bisphenol A epoxy resin sensitivity. | 2002-09 |
|
| Degradation of triglycidyl isocyanurate as a cause of false-negative patch test reaction. | 2001-01 |
|
| Occupational allergic contact dermatitis caused by 2,4,6-tris-(dimethylaminomethyl)phenol, and review of sensitizing epoxy resin hardeners. | 1996-12 |
|
| Concomitant sensitization to triglycidyl isocyanurate, diaminodiphenylmethane and 2-hydroxyethyl methacrylate from silk-screen printing coatings in the manufacture of circuit boards. | 1994-01 |
|
| Pharmacological characterization of teroxirone, a triepoxide antitumor agent, in rats, rabbits, and humans. | 1984-09 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Tue Apr 01 16:43:18 GMT 2025
by
admin
on
Tue Apr 01 16:43:18 GMT 2025
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| Record UNII |
24N3OU2YDR
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| Record Status |
Validated (UNII)
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| Record Version |
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240408-79-1
Created by
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6917771
Created by
admin on Tue Apr 01 16:43:18 GMT 2025 , Edited by admin on Tue Apr 01 16:43:18 GMT 2025
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24N3OU2YDR
Created by
admin on Tue Apr 01 16:43:18 GMT 2025 , Edited by admin on Tue Apr 01 16:43:18 GMT 2025
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RACEMATE -> ENANTIOMER |
