Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C12H15N3O6 |
| Molecular Weight | 297.264 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O=C1N(C[C@H]2CO2)C(=O)N(C[C@@H]3CO3)C(=O)N1C[C@@H]4CO4
InChI
InChIKey=OUPZKGBUJRBPGC-HLTSFMKQSA-N
InChI=1S/C12H15N3O6/c16-10-13(1-7-4-19-7)11(17)15(3-9-6-21-9)12(18)14(10)2-8-5-20-8/h7-9H,1-6H2/t7-,8-,9+/m1/s1
| Molecular Formula | C12H15N3O6 |
| Molecular Weight | 297.264 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Teroxirone is a triazene triepoxide patented by Shell Internationale Research Maatschappij NV as an antineoplastic agent. Teroxirone alkylates and cross-links DNA, thereby inhibiting DNA replication. Teroxirone has good cytotoxic activity against sublines of P388 and L1210 leukemias resistant to another alkylating agent. In preclinical trials, Teroxirone shows potent antineoplastic activity against murine tumors. In clinical trials, Teroxirone shows good anticancer activity and high rate of adverse events including nausea, vomiting, and myelosuppression.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Concomitant sensitization to triglycidyl isocyanurate, diaminodiphenylmethane and 2-hydroxyethyl methacrylate from silk-screen printing coatings in the manufacture of circuit boards. | 1994 Jan |
|
| Occupational allergic contact dermatitis caused by 2,4,6-tris-(dimethylaminomethyl)phenol, and review of sensitizing epoxy resin hardeners. | 1996 Dec |
|
| Degradation of triglycidyl isocyanurate as a cause of false-negative patch test reaction. | 2001 Jan |
|
| Cross-reactivity among epoxy acrylates and bisphenol F epoxy resins in patients with bisphenol A epoxy resin sensitivity. | 2002 Sep |
|
| Determination of triglycidyl isocyanurate from powder coatings in occupational hygiene samples by gas chromatography with mass spectrometric detection. | 2004 Aug |
|
| A novel chip device based on wired capillary packed with high performance polymer-based monolith for HPLC: reproducibility in preparation processes to obtain long columns. | 2008 Jan |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 11:39:16 GMT 2023
by
admin
on
Sat Dec 16 11:39:16 GMT 2023
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| Record UNII |
24N3OU2YDR
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| Record Status |
Validated (UNII)
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| Record Version |
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6917771
Created by
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24N3OU2YDR
Created by
admin on Sat Dec 16 11:39:17 GMT 2023 , Edited by admin on Sat Dec 16 11:39:17 GMT 2023
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RACEMATE -> ENANTIOMER |
