MIPAFOX

Details

Stereochemistry	ACHIRAL
Molecular Formula	C6H16FN2OP
Molecular Weight	182.1762
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)NP(F)(=O)NC(C)C

InChI

InChIKey=UOSHUBFBCPGQAY-UHFFFAOYSA-N

InChI=1S/C6H16FN2OP/c1-5(2)8-11(7,10)9-6(3)4/h5-6H,1-4H3,(H2,8,9,10)

HIDE SMILES / InChI

Molecular Formula	C6H16FN2OP
Molecular Weight	182.1762
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Resolving pathways of interaction of mipafox and a sarin analog with human acetylcholinesterase by kinetics, mass spectrometry and molecular modeling approaches.	2016-03	25743373
Genomic and phenotypic alterations of the neuronal-like cells derived from human embryonal carcinoma stem cells (NT2) caused by exposure to organophosphorus compounds paraoxon and mipafox.	2014-01-09	24413757
Motor neuron disease due to neuropathy target esterase mutation: enzyme analysis of fibroblasts from human subjects yields insights into pathogenesis.	2010-11-10	20603202
Constructs of human neuropathy target esterase catalytic domain containing mutations related to motor neuron disease have altered enzymatic properties.	2010-07-01	20382209
Effect of inhibition of neuropathy target esterase in mouse nervous tissues in vitro on phosphatidylcholine and lysophosphatidylcholine homeostasis.	2009-07-22	19620706
Mechanism of aging of mipafox-inhibited butyrylcholinesterase.	2007-03	17323978
Degradation of organophosphorus neurotoxicity in SY5Y neuroblastoma cells by organophosphorus hydrolase (OPH).	2006-08	16766477
Aging of mipafox-inhibited human acetylcholinesterase proceeds by displacement of both isopropylamine groups to yield a phosphate adduct.	2006-02	16485911
Weak inhibitors protect cholinesterases from strong inhibitors (paraoxon): in vitro effect of tiapride.	2005-09-30	16193528
In vitro protection of plasma cholinesterases by metoclopramide from inhibition by mipafox.	2004-03-31	15052610
The mipafox-inhibited catalytic domain of human neuropathy target esterase ages by reversible proton loss.	2004-03-30	15035642
In vitro protection of red blood cell acetylcholinesterase by metoclopramide from inhibition by organophosphates (paraoxon and mipafox).	2003-11-25	14635269
Biosensor detection of neuropathy target esterase in whole blood as a biomarker of exposure to neuropathic organophosphorus compounds.	2003-04-11	12746135
Inhibition of carboxylesterases in SH-SY5Y human and NB41A3 mouse neuroblastoma cells by organophosphorus esters.	1998-03-13	9515941
Acetylcholinesterase and neuropathy target esterase inhibitions in neuroblastoma cells to distinguish organophosphorus compounds causing acute and delayed neurotoxicity.	1997-07	9268605
Comparison of the relative inhibition of acetylcholinesterase and neuropathy target esterase in rats and hens given cholinesterase inhibitors.	1995-01	7713347
Interactions between neuropathy target esterase and its inhibitors and the development of polyneuropathy.	1993-10	8211998
Biochemical properties and possible toxicological significance of various forms of NTE.	1993-06	8343994
Delayed neurotoxic effect of sarin in mice after repeated inhalation exposure.	1993-03-01	8486913
Comparative dose-response studies of organophosphorus ester-induced delayed neuropathy in rats and hens administered mipafox.	1992	1302301
Comparative evolution of mipafox-induced delayed neuropathy in rats and hens.	1992	1302299
Age sensitivity to organophosphate-induced delayed polyneuropathy. Biochemical and toxicological studies in developing chicks.	1991-05-15	2018554
The correlation between neurotoxic esterase inhibition and mipafox-induced neuropathic damage in rats.	1986	3714122
Phenylmethylsulfonyl fluoride protects rats from Mipafox-induced delayed neuropathy.	1985-11	4060153
Striatal neurochemical changes and motor dysfunction in mipafox-treated animals.	1985-02	2859406

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:20:02 GMT 2025` Edited by `admin` on `Mon Mar 31 19:20:02 GMT 2025`
Record UNII	24MJP5H3YN
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MIPAFOX

Common Name

English

NSC-8924

Preferred Name

English

N,N'-DIISOPROPYLPHOSPHORODIAMIDIC FLUORIDE

Systematic Name

English

MIPAFOX [MI]

Common Name

English

N,N'-BIS(1-METHYLETHYL)PHOSPHORODIAMIDIC FLUORIDE

Systematic Name

English

MIPAFOX [HSDB]

Common Name

English

MIPAFOX [ISO]

Common Name

English

Classification Tree Code System Code

EPA PESTICIDE CODE

356300