MIPAFOX

Details

Stereochemistry	ACHIRAL
Molecular Formula	C6H16FN2OP
Molecular Weight	182.1762
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)NP(F)(=O)NC(C)C

InChI

InChIKey=UOSHUBFBCPGQAY-UHFFFAOYSA-N

InChI=1S/C6H16FN2OP/c1-5(2)8-11(7,10)9-6(3)4/h5-6H,1-4H3,(H2,8,9,10)

HIDE SMILES / InChI

Molecular Formula	C6H16FN2OP
Molecular Weight	182.1762
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Striatal neurochemical changes and motor dysfunction in mipafox-treated animals.	1985 Feb	2859406
Phenylmethylsulfonyl fluoride protects rats from Mipafox-induced delayed neuropathy.	1985 Nov	4060153
The correlation between neurotoxic esterase inhibition and mipafox-induced neuropathic damage in rats.	1986 Spring	3714122
Age sensitivity to organophosphate-induced delayed polyneuropathy. Biochemical and toxicological studies in developing chicks.	1991 May 15	2018554
Comparative dose-response studies of organophosphorus ester-induced delayed neuropathy in rats and hens administered mipafox.	1992 Winter	1302301
Comparative evolution of mipafox-induced delayed neuropathy in rats and hens.	1992 Winter	1302299
Biochemical properties and possible toxicological significance of various forms of NTE.	1993 Jun	8343994
Delayed neurotoxic effect of sarin in mice after repeated inhalation exposure.	1993 Mar-Apr	8486913
Interactions between neuropathy target esterase and its inhibitors and the development of polyneuropathy.	1993 Oct	8211998
Comparison of the relative inhibition of acetylcholinesterase and neuropathy target esterase in rats and hens given cholinesterase inhibitors.	1995 Jan	7713347
Acetylcholinesterase and neuropathy target esterase inhibitions in neuroblastoma cells to distinguish organophosphorus compounds causing acute and delayed neurotoxicity.	1997 Jul	9268605
Inhibition of carboxylesterases in SH-SY5Y human and NB41A3 mouse neuroblastoma cells by organophosphorus esters.	1998 Mar 13	9515941
Biosensor detection of neuropathy target esterase in whole blood as a biomarker of exposure to neuropathic organophosphorus compounds.	2003 Apr 11	12746135
In vitro protection of red blood cell acetylcholinesterase by metoclopramide from inhibition by organophosphates (paraoxon and mipafox).	2003 Nov-Dec	14635269
The mipafox-inhibited catalytic domain of human neuropathy target esterase ages by reversible proton loss.	2004 Mar 30	15035642
In vitro protection of plasma cholinesterases by metoclopramide from inhibition by mipafox.	2004 Mar-Apr	15052610
Weak inhibitors protect cholinesterases from strong inhibitors (paraoxon): in vitro effect of tiapride.	2005 Nov-Dec	16193528
Degradation of organophosphorus neurotoxicity in SY5Y neuroblastoma cells by organophosphorus hydrolase (OPH).	2006 Aug	16766477
Aging of mipafox-inhibited human acetylcholinesterase proceeds by displacement of both isopropylamine groups to yield a phosphate adduct.	2006 Feb	16485911
Mechanism of aging of mipafox-inhibited butyrylcholinesterase.	2007 Mar	17323978
Effect of inhibition of neuropathy target esterase in mouse nervous tissues in vitro on phosphatidylcholine and lysophosphatidylcholine homeostasis.	2009 Sep-Oct	19620706
Constructs of human neuropathy target esterase catalytic domain containing mutations related to motor neuron disease have altered enzymatic properties.	2010 Jul 1	20382209
Motor neuron disease due to neuropathy target esterase mutation: enzyme analysis of fibroblasts from human subjects yields insights into pathogenesis.	2010 Nov 10	20603202
Genomic and phenotypic alterations of the neuronal-like cells derived from human embryonal carcinoma stem cells (NT2) caused by exposure to organophosphorus compounds paraoxon and mipafox.	2014 Jan 9	24413757
Resolving pathways of interaction of mipafox and a sarin analog with human acetylcholinesterase by kinetics, mass spectrometry and molecular modeling approaches.	2016 Mar	25743373

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:44:48 GMT 2023` Edited by `admin` on `Fri Dec 15 18:44:48 GMT 2023`
Record UNII	24MJP5H3YN
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MIPAFOX

Common Name

English

N,N'-DIISOPROPYLPHOSPHORODIAMIDIC FLUORIDE

Systematic Name

English

MIPAFOX [MI]

Common Name

English

N,N'-BIS(1-METHYLETHYL)PHOSPHORODIAMIDIC FLUORIDE

Systematic Name

English

MIPAFOX [HSDB]

Common Name

English

NSC-8924

Code

English

MIPAFOX [ISO]

Common Name

English

Classification Tree Code System Code

EPA PESTICIDE CODE

356300