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Details

Stereochemistry ACHIRAL
Molecular Formula C7H10N2
Molecular Weight 122.1677
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TOLUENE-2,5-DIAMINE

SMILES

CC1=CC(N)=CC=C1N

InChI

InChIKey=OBCSAIDCZQSFQH-UHFFFAOYSA-N
InChI=1S/C7H10N2/c1-5-4-6(8)2-3-7(5)9/h2-4H,8-9H2,1H3

HIDE SMILES / InChI
Molecular Formula C7H10N2
Molecular Weight 122.1677
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

2016
494
PubMed

PubMed

TitleDatePubMed
Biological transformation pathways of 2,4-dinitro anisole and N-methyl paranitro aniline in anaerobic fluidized-bed bioreactors.
2010-11
Final amended report of the safety assessment of toluene-2,5-diamine, toluene-2,5-diamine sulfate, and toluene-3,4-diamine as used in cosmetics.
2010-05
Para-phenylenediamine-specific lymphocyte activation test: a sensitive in vitro assay to detect para-phenylenediamine sensitization in patients with severe allergic reactions.
2010-05
Severe inflammatory and keloidal, allergic reaction due to para-phenylenediamine in temporary tattoos.
2010-03-16
Metabolite screening of aromatic amine hair dyes using in vitro hepatic models.
2009-11
Occupational health risks of barbers and coiffeurs in Izmir.
2009-08
Hairdye-induced hepatitis: an unusal cause of acute hepatitis.
2009-04
[Results of patch test in hairdressers examined in the institute of occupational medicine in Łódź].
2009
Cross-reactions among hair dye allergens.
2009
Reactivity of in vitro activated human T lymphocytes to p-phenylenediamine and related substances.
2008-10
[Determination of 22 components in hair dyes by high performance liquid chromatography].
2008-09
Primary sensitization to toluene-2,5-diamine giving rise to early positive patch reaction to p-phenylenediamine and late to toluene-2,5-diamine.
2008-09
A clinical assessment of a patch test kit marketed to U.K. hairdressers for detecting hair dye allergy.
2007-11
The reaction mechanism of p-toluenediamine anodic oxidation: an in situ ESR-UV/Vis/NIR spectroelectrochemical study.
2007-10-08
Allergic contact dermatitis from toluene-2,5-diamine in a cream dye for eyelashes and eyebrows--quantitative exposure assessment.
2007-09
Toluene-2,5-diamine may be an isolated allergy in individuals sensitized by permanent hair dye.
2007-09
Permeability of hair dye compounds p-phenylenediamine, toluene-2,5-diaminesulfate and resorcinol through protective gloves in hairdressing.
2007-07
[The expanding role of occupational and non-occupational allergy to paraphenylenediamine].
2007
Unconsumed precursors and couplers after formation of oxidative hair dyes.
2006-08
Different results of the Salmonella umu test between three isomers of phenylenediamine (PDA) derivatives.
2006
Occupational dermal exposure to permanent hair dyes among hairdressers.
2005-08
Patch test reactions to cosmetic allergens in 1995-1997 and 2000-2002 in Finland--a multicentre study.
2005-07
Hair dye contact allergy: quantitative exposure assessment of selected products and clinical cases.
2004-06
Characterization of the sensitizing potential of chemicals by in vitro analysis of dendritic cell activation and skin penetration.
2004-05
Contact allergy to ingredients of hair cosmetics in female hairdressers and clients--an 8-year analysis of IVDK data.
2003-11
Thiol antioxidants block the activation of antigen-presenting cells by contact sensitizers.
2003-11
Hair dye-sensitized hairdressers: the cross-reaction pattern with new generation hair dyes.
2002-06
Comparative investigation of multiple organs of mice and rats in the comet assay.
2002-05-27
The spectrum of allergic (cross-)sensitivity in clinical patch testing with 'para amino' compounds.
2002-04
Is benzoquinone the prohapten in cross-sensitivity among aminobenzene compounds?
1998-12
Patents

Patents

JP2000290346A
3
JP2002255759A
3
JP2002255760A
3
JP2009078985A
3
JP3556216B2
4
JPH03112920A
5
JPH08239313A
3
JPS6420232A
3
Substance Class Chemical
Created
by admin
on Mon Mar 31 19:34:03 GMT 2025
Edited
by admin
on Mon Mar 31 19:34:03 GMT 2025
Record UNII
24JO8Z0RJU
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PARATOLUENEDIAMINE
MART.  
Preferred Name English
TOLUENE-2,5-DIAMINE
INCI  
INCI  
Official Name English
2,5-TOLUENEDIAMINE
Systematic Name English
2,5-DIAMINOTOLUENE
Systematic Name English
1-METHYL-2,5-DIAMINOBENZENE
Systematic Name English
2-METHYL-1,4-PHENYLENEDIAMINE
Systematic Name English
PARATOLUENEDIAMINE [MART.]
Common Name English
2,5-DIAMINOTOLUENE [IARC]
Common Name English
2-METHYL-1,4-BENZENEDIAMINE [HSDB]
Common Name English
2-METHYL-P-PHENYLENEDIAMINE
Common Name English
1,4-DIAMINO-2-METHYLBENZENE
Systematic Name English
C.I. 76042
Common Name English
2-METHYL-1,4-BENZENEDIAMINE
HSDB  
Systematic Name English
4-AMINO-3-METHYLANILINE
Systematic Name English
4-AMINO-2-METHYLANILINE
Systematic Name English
Code System Code Type Description
EVMPD
SUB169432
Created by admin on Mon Mar 31 19:34:04 GMT 2025 , Edited by admin on Mon Mar 31 19:34:04 GMT 2025
PRIMARY
EPA CompTox
DTXSID6029123
Created by admin on Mon Mar 31 19:34:04 GMT 2025 , Edited by admin on Mon Mar 31 19:34:04 GMT 2025
PRIMARY
SMS_ID
100000159425
Created by admin on Mon Mar 31 19:34:04 GMT 2025 , Edited by admin on Mon Mar 31 19:34:04 GMT 2025
PRIMARY
MESH
C007303
Created by admin on Mon Mar 31 19:34:03 GMT 2025 , Edited by admin on Mon Mar 31 19:34:03 GMT 2025
PRIMARY
RXCUI
1482535
Created by admin on Mon Mar 31 19:34:04 GMT 2025 , Edited by admin on Mon Mar 31 19:34:04 GMT 2025
PRIMARY RxNorm
FDA UNII
24JO8Z0RJU
Created by admin on Mon Mar 31 19:34:04 GMT 2025 , Edited by admin on Mon Mar 31 19:34:04 GMT 2025
PRIMARY
PUBCHEM
7252
Created by admin on Mon Mar 31 19:34:04 GMT 2025 , Edited by admin on Mon Mar 31 19:34:04 GMT 2025
PRIMARY
CHEBI
53619
Created by admin on Mon Mar 31 19:34:04 GMT 2025 , Edited by admin on Mon Mar 31 19:34:04 GMT 2025
PRIMARY
WIKIPEDIA
2,5-DIAMINOTOLUENE
Created by admin on Mon Mar 31 19:34:03 GMT 2025 , Edited by admin on Mon Mar 31 19:34:03 GMT 2025
PRIMARY
HSDB
6251
Created by admin on Mon Mar 31 19:34:04 GMT 2025 , Edited by admin on Mon Mar 31 19:34:04 GMT 2025
PRIMARY
CAS
95-70-5
Created by admin on Mon Mar 31 19:34:03 GMT 2025 , Edited by admin on Mon Mar 31 19:34:03 GMT 2025
PRIMARY
DAILYMED
24JO8Z0RJU
Created by admin on Mon Mar 31 19:34:04 GMT 2025 , Edited by admin on Mon Mar 31 19:34:04 GMT 2025
PRIMARY
ECHA (EC/EINECS)
202-442-1
Created by admin on Mon Mar 31 19:34:04 GMT 2025 , Edited by admin on Mon Mar 31 19:34:04 GMT 2025
PRIMARY
Related Record Type Details
Structure of TOLUENE-2,5-DIAMINE DIHYDROCHLORIDE
SALT/SOLVATE -> PARENT
Structure of 2,5-DIAMINOTOLUENE SULFATE
SALT/SOLVATE -> PARENT
Related Record Type Details
Structure of TOLUENE-2,5-DIAMINE
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