Details
Stereochemistry | ACHIRAL |
Molecular Formula | Ba |
Molecular Weight | 137.327 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Ba]
InChI
InChIKey=MUBOSUMMMUSVEO-UHFFFAOYSA-N
InChI=1S/Ba.2H
Molecular Formula | Ba |
Molecular Weight | 137.327 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Barium is a soft, silvery metal that rapidly tarnishes in air and reacts with water. Barium is not an extensively used element. Most is used in drilling fluids for oil and gas wells. It is also used in paint and in glassmaking. All barium compounds are toxic; however, barium sulfate is insoluble and so can be safely swallowed. A suspension of barium sulfate is sometimes given to patients suffering from digestive disorders. This is a ‘barium meal’ or ‘barium enema’. Barium is a heavy element and scatters X-rays, so as it passes through the body the stomach and intestines can be distinguished on an X-ray. Barium carbonate has been used in the past as a rat poison. Barium nitrate gives fireworks a green colour. Barium has no known biological role, although barium sulfate has been found in one particular type of algae. Barium is toxic, as are its water- or acid-soluble compounds. This drug is used as a contrast agent in diagnostic x-ray procedures. Therapeutic advantages of barium sulfate in diagnostic procedures include both its low water solubility and high level of clearance from the body. Barium sulfate is ingested by mouth or administered rectally and combined with granules of effervescent bicarbonate to enhance distension of the GI tract, allowing for enhanced gastrointestinal tract visualization. Barium (E-Z-CAT DRY) is a radiographic contrast agent indicated for use in computed tomography (CT) of the abdomen to delineate the gastrointestinal (GI) tract in adult and pediatric patients. Under physiological conditions, barium sulfate passes through the GI tract in an unchanged form and is absorbed only in pharmacologically insignificant amounts. Common adverse reactions include nausea, vomiting, diarrhea and abdominal cramping.
Approval Year
PubMed
Title | Date | PubMed |
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[The anti-arrhythmia activity of isoteolin (IST)]. | 1990 |
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Arachidonic acid-induced calcium influx in human platelets. Comparison with the effect of thrombin. | 1990 Dec 1 |
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ROMK1 (Kir1.1) causes apoptosis and chronic silencing of hippocampal neurons. | 2000 Aug |
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D2 dopamine receptors in striatal medium spiny neurons reduce L-type Ca2+ currents and excitability via a novel PLC[beta]1-IP3-calcineurin-signaling cascade. | 2000 Dec 15 |
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Inactivation properties of human recombinant class E calcium channels. | 2000 Feb |
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Kir3.1/3.2 encodes an I(KACh)-like current in gastrointestinal myocytes. | 2000 Feb |
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KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels. | 2000 Jun |
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Cloning and expression of the human transient receptor potential 4 (TRP4) gene: localization and functional expression of human TRP4 and TRP3. | 2000 Nov 1 |
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Selective regulation of N-type Ca channels by different combinations of G-protein beta/gamma subunits and RGS proteins. | 2000 Oct 1 |
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The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha(1)-adrenoceptor-activated Ca(2+)-permeable cation channel. | 2001 Feb 16 |
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Functional expression and characterization of a voltage-gated CaV1.3 (alpha1D) calcium channel subunit from an insulin-secreting cell line. | 2001 Jul |
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Heterologous expression of the Na(+),K(+)-ATPase gamma subunit in Xenopus oocytes induces an endogenous, voltage-gated large diameter pore. | 2001 Sep 1 |
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The role of endogenous human Trp4 in regulating carbachol-induced calcium oscillations in HEK-293 cells. | 2002 Apr 19 |
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Activation of ion secretion via proteinase-activated receptor-2 in human colon. | 2002 Feb |
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Cloning of rabbit Kir6.1, SUR2A, and SUR2B: possible candidates for a renal K(ATP) channel. | 2002 Feb |
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Inhibition of transiently expressed low- and high-voltage-activated calcium channels by trivalent metal cations. | 2002 Jun 1 |
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Diacylglycerol activates the influx of extracellular cations in T-lymphocytes independently of intracellular calcium-store depletion and possibly involving endogenous TRP6 gene products. | 2002 May 15 |
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Five ADNFLE mutations reduce the Ca2+ dependence of the mammalian alpha4beta2 acetylcholine response. | 2003 Jul 1 |
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A novel two-pore domain K+ channel, TRESK, is localized in the spinal cord. | 2003 Jul 25 |
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The renal-specific transporter mediates facilitative transport of organic anions at the brush border membrane of mouse renal tubules. | 2004 Aug |
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Null mutation of alpha1D Ca2+ channel gene results in deafness but no vestibular defect in mice. | 2004 Jun |
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A Kir2.3-like K+ conductance in mouse cortical collecting duct principal cells. | 2006 |
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Role of the outer beta-sheet in divalent cation modulation of alpha7 nicotinic receptors. | 2006 Jul |
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Involvement of Kv1.1 and Nav1.5 in proliferation of gastric epithelial cells. | 2006 May |
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Persistence of Ca(v)1.3 Ca2+ channels in mature outer hair cells supports outer hair cell afferent signaling. | 2007 Jun 13 |
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An examination of the association of selected toxic metals with total and central obesity indices: NHANES 99-02. | 2010 Sep |
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Heavy metal cations permeate the TRPV6 epithelial cation channel. | 2011 Jan |
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The effects of jaspamide on human cardiomyocyte function and cardiac ion channel activity. | 2013 Mar |
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Enhanced constitutive invasion activity in human nontumorigenic keratinocytes exposed to a low level of barium for a long time. | 2015 Feb |
Sample Use Guides
DOSAGE AND ADMINISTRATION
Recommended reconstituted oral dose for adults and pediatric patients older than 12 years of age is between 450 mL to 900 mL (9 g to 18 g of barium sulfate, respectively) (2.1) •Pediatric patents younger than 12 years of age adjust reconstituted oral dose based on relative GI volume (2.1) •Must reconstitute supplied powder with water prior to use
Route of Administration:
Oral
Substance Class |
Chemical
Created
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admin
on
Edited
Fri Dec 15 17:00:47 GMT 2023
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on
Fri Dec 15 17:00:47 GMT 2023
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Record UNII |
24GP945V5T
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Record Status |
Validated (UNII)
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Record Version |
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LOINC |
76653-5
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DSLD |
233 (Number of products:27)
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NCI_THESAURUS |
C1940
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1311067
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C61475
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5355457
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24GP945V5T
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7440-39-3
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SUB12987MIG
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15010-01-2
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24GP945V5T
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100000077143
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Barium
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4481
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32595
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37136
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DTXSID30161173
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DB12481
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32594
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231-149-1
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13981-97-0
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D001464
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m2230
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PRIMARY | Merck Index |
Related Record | Type | Details | ||
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ACTIVE MOIETY |