Details
Stereochemistry | ACHIRAL |
Molecular Formula | Ba |
Molecular Weight | 137.327 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Ba]
InChI
InChIKey=MUBOSUMMMUSVEO-UHFFFAOYSA-N
InChI=1S/Ba.2H
Molecular Formula | Ba |
Molecular Weight | 137.327 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Barium is a soft, silvery metal that rapidly tarnishes in air and reacts with water. Barium is not an extensively used element. Most is used in drilling fluids for oil and gas wells. It is also used in paint and in glassmaking. All barium compounds are toxic; however, barium sulfate is insoluble and so can be safely swallowed. A suspension of barium sulfate is sometimes given to patients suffering from digestive disorders. This is a ‘barium meal’ or ‘barium enema’. Barium is a heavy element and scatters X-rays, so as it passes through the body the stomach and intestines can be distinguished on an X-ray. Barium carbonate has been used in the past as a rat poison. Barium nitrate gives fireworks a green colour. Barium has no known biological role, although barium sulfate has been found in one particular type of algae. Barium is toxic, as are its water- or acid-soluble compounds. This drug is used as a contrast agent in diagnostic x-ray procedures. Therapeutic advantages of barium sulfate in diagnostic procedures include both its low water solubility and high level of clearance from the body. Barium sulfate is ingested by mouth or administered rectally and combined with granules of effervescent bicarbonate to enhance distension of the GI tract, allowing for enhanced gastrointestinal tract visualization. Barium (E-Z-CAT DRY) is a radiographic contrast agent indicated for use in computed tomography (CT) of the abdomen to delineate the gastrointestinal (GI) tract in adult and pediatric patients. Under physiological conditions, barium sulfate passes through the GI tract in an unchanged form and is absorbed only in pharmacologically insignificant amounts. Common adverse reactions include nausea, vomiting, diarrhea and abdominal cramping.
Approval Year
PubMed
Title | Date | PubMed |
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[The anti-arrhythmia activity of isoteolin (IST)]. | 1990 |
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Arachidonic acid-induced calcium influx in human platelets. Comparison with the effect of thrombin. | 1990 Dec 1 |
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The status of voltage-dependent calcium channels in alpha 1E knock-out mice. | 2000 Dec 1 |
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D2 dopamine receptors in striatal medium spiny neurons reduce L-type Ca2+ currents and excitability via a novel PLC[beta]1-IP3-calcineurin-signaling cascade. | 2000 Dec 15 |
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Inactivation properties of human recombinant class E calcium channels. | 2000 Feb |
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Kir3.1/3.2 encodes an I(KACh)-like current in gastrointestinal myocytes. | 2000 Feb |
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alpha(1E) subunits form the pore of three cerebellar R-type calcium channels with different pharmacological and permeation properties. | 2000 Jan 1 |
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KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels. | 2000 Jun |
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TASK-3, a new member of the tandem pore K(+) channel family. | 2000 Mar 31 |
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Comparison of cloned Kir2 channels with native inward rectifier K+ channels from guinea-pig cardiomyocytes. | 2001 Apr 1 |
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The involvement of L-type Ca(2+) channels in the relaxant effects of the ATP-sensitive K(+) channel opener ZD6169 on pig urethral smooth muscle. | 2001 Dec |
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Functional coupling between 'R-type' Ca2+ channels and insulin secretion in the insulinoma cell line INS-1. | 2001 Feb |
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The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha(1)-adrenoceptor-activated Ca(2+)-permeable cation channel. | 2001 Feb 16 |
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Functional expression and characterization of a voltage-gated CaV1.3 (alpha1D) calcium channel subunit from an insulin-secreting cell line. | 2001 Jul |
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Functional roles of gamma2, gamma3 and gamma4, three new Ca2+ channel subunits, in P/Q-type Ca2+ channel expressed in Xenopus oocytes. | 2001 May 1 |
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Evidence supporting a role for KCl cotransporter in the thick ascending limb of Henle's loop. | 2001 Nov |
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Heterologous expression of the Na(+),K(+)-ATPase gamma subunit in Xenopus oocytes induces an endogenous, voltage-gated large diameter pore. | 2001 Sep 1 |
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The role of endogenous human Trp4 in regulating carbachol-induced calcium oscillations in HEK-293 cells. | 2002 Apr 19 |
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The functional properties of the human ether-à-go-go-like (HELK2) K+ channel. | 2002 Aug |
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Cloning of rabbit Kir6.1, SUR2A, and SUR2B: possible candidates for a renal K(ATP) channel. | 2002 Feb |
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Identification and characterization of novel human Ca(v)2.2 (alpha 1B) calcium channel variants lacking the synaptic protein interaction site. | 2002 Jan 1 |
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Inhibitory effects of opioids on voltage-dependent Ca(2+) channels and catecholamine secretion in cultured porcine adrenal chromaffin cells. | 2002 Jun 28 |
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Diacylglycerol activates the influx of extracellular cations in T-lymphocytes independently of intracellular calcium-store depletion and possibly involving endogenous TRP6 gene products. | 2002 May 15 |
|
Guanylin, uroguanylin, and heat-stable euterotoxin activate guanylate cyclase C and/or a pertussis toxin-sensitive G protein in human proximal tubule cells. | 2002 May 17 |
|
Five ADNFLE mutations reduce the Ca2+ dependence of the mammalian alpha4beta2 acetylcholine response. | 2003 Jul 1 |
|
Auxiliary subunit regulation of high-voltage activated calcium channels expressed in mammalian cells. | 2004 Jul |
|
A Kir2.3-like K+ conductance in mouse cortical collecting duct principal cells. | 2006 |
|
Characterization of recombinant human cardiac KCNQ1/KCNE1 channels (I (Ks)) stably expressed in HEK 293 cells. | 2006 Apr |
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Regulation of the cardiac L-type calcium channel in L6 cells by arginine-vasopressin. | 2006 Dec 15 |
|
Essential, completely conserved glycine residue in the domain III S2-S3 linker of voltage-gated calcium channel alpha1 subunits in yeast and mammals. | 2007 Aug 31 |
|
Persistence of Ca(v)1.3 Ca2+ channels in mature outer hair cells supports outer hair cell afferent signaling. | 2007 Jun 13 |
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Functional ion channels in mouse bone marrow mesenchymal stem cells. | 2007 Nov |
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Involvement of voltage-gated K+ and Na+ channels in gastric epithelial cell migration. | 2008 Jan |
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Tamoxifen inhibits TRPV6 activity via estrogen receptor-independent pathways in TRPV6-expressing MCF-7 breast cancer cells. | 2009 Dec |
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An examination of the association of selected toxic metals with total and central obesity indices: NHANES 99-02. | 2010 Sep |
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Antispasmodic effects of eugenol on rat airway smooth muscle. | 2011 Dec |
|
Heavy metal cations permeate the TRPV6 epithelial cation channel. | 2011 Jan |
|
The effects of jaspamide on human cardiomyocyte function and cardiac ion channel activity. | 2013 Mar |
|
Enhanced constitutive invasion activity in human nontumorigenic keratinocytes exposed to a low level of barium for a long time. | 2015 Feb |
Sample Use Guides
DOSAGE AND ADMINISTRATION
Recommended reconstituted oral dose for adults and pediatric patients older than 12 years of age is between 450 mL to 900 mL (9 g to 18 g of barium sulfate, respectively) (2.1) •Pediatric patents younger than 12 years of age adjust reconstituted oral dose based on relative GI volume (2.1) •Must reconstitute supplied powder with water prior to use
Route of Administration:
Oral
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 17:00:47 UTC 2023
by
admin
on
Fri Dec 15 17:00:47 UTC 2023
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Record UNII |
24GP945V5T
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Record Status |
Validated (UNII)
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Record Version |
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LOINC |
76653-5
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DSLD |
233 (Number of products:27)
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NCI_THESAURUS |
C1940
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1311067
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C61475
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5355457
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24GP945V5T
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7440-39-3
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SUB12987MIG
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15010-01-2
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24GP945V5T
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100000077143
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Barium
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4481
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32595
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37136
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DTXSID30161173
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DB12481
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32594
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231-149-1
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13981-97-0
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D001464
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m2230
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PRIMARY | Merck Index |
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