U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula Ba
Molecular Weight 137.327
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BARIUM

SMILES

[Ba]

InChI

InChIKey=MUBOSUMMMUSVEO-UHFFFAOYSA-N
InChI=1S/Ba.2H

HIDE SMILES / InChI

Molecular Formula Ba
Molecular Weight 137.327
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Barium is a soft, silvery metal that rapidly tarnishes in air and reacts with water. Barium is not an extensively used element. Most is used in drilling fluids for oil and gas wells. It is also used in paint and in glassmaking. All barium compounds are toxic; however, barium sulfate is insoluble and so can be safely swallowed. A suspension of barium sulfate is sometimes given to patients suffering from digestive disorders. This is a ‘barium meal’ or ‘barium enema’. Barium is a heavy element and scatters X-rays, so as it passes through the body the stomach and intestines can be distinguished on an X-ray. Barium carbonate has been used in the past as a rat poison. Barium nitrate gives fireworks a green colour. Barium has no known biological role, although barium sulfate has been found in one particular type of algae. Barium is toxic, as are its water- or acid-soluble compounds. This drug is used as a contrast agent in diagnostic x-ray procedures. Therapeutic advantages of barium sulfate in diagnostic procedures include both its low water solubility and high level of clearance from the body. Barium sulfate is ingested by mouth or administered rectally and combined with granules of effervescent bicarbonate to enhance distension of the GI tract, allowing for enhanced gastrointestinal tract visualization. Barium (E-Z-CAT DRY) is a radiographic contrast agent indicated for use in computed tomography (CT) of the abdomen to delineate the gastrointestinal (GI) tract in adult and pediatric patients. Under physiological conditions, barium sulfate passes through the GI tract in an unchanged form and is absorbed only in pharmacologically insignificant amounts. Common adverse reactions include nausea, vomiting, diarrhea and abdominal cramping.

Approval Year

PubMed

PubMed

TitleDatePubMed
Enhanced constitutive invasion activity in human nontumorigenic keratinocytes exposed to a low level of barium for a long time.
2015-02
The effects of jaspamide on human cardiomyocyte function and cardiac ion channel activity.
2013-03
Antispasmodic effects of eugenol on rat airway smooth muscle.
2011-12
Heavy metal cations permeate the TRPV6 epithelial cation channel.
2011-01
An examination of the association of selected toxic metals with total and central obesity indices: NHANES 99-02.
2010-09
Tamoxifen inhibits TRPV6 activity via estrogen receptor-independent pathways in TRPV6-expressing MCF-7 breast cancer cells.
2009-12
Involvement of voltage-gated K+ and Na+ channels in gastric epithelial cell migration.
2008-01
Functional ion channels in mouse bone marrow mesenchymal stem cells.
2007-11
Essential, completely conserved glycine residue in the domain III S2-S3 linker of voltage-gated calcium channel alpha1 subunits in yeast and mammals.
2007-08-31
Persistence of Ca(v)1.3 Ca2+ channels in mature outer hair cells supports outer hair cell afferent signaling.
2007-06-13
Ncx (Enx, Hox11L.1) is required for neuronal cell death in enteric ganglia of mice.
2007-06
Regulation of the cardiac L-type calcium channel in L6 cells by arginine-vasopressin.
2006-12-15
Adaptive downregulation of a quinidine-sensitive cation conductance in renal principal cells of TWIK-1 knockout mice.
2006-10
Role of the outer beta-sheet in divalent cation modulation of alpha7 nicotinic receptors.
2006-07
Involvement of Kv1.1 and Nav1.5 in proliferation of gastric epithelial cells.
2006-05
Characterization of recombinant human cardiac KCNQ1/KCNE1 channels (I (Ks)) stably expressed in HEK 293 cells.
2006-04
Functional expression of inward rectifier potassium channels in cultured human pulmonary smooth muscle cells: evidence for a major role of Kir2.4 subunits.
2006
A Kir2.3-like K+ conductance in mouse cortical collecting duct principal cells.
2006
Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2.
2005-11
The role of canonical transient receptor potential 7 in B-cell receptor-activated channels.
2005-10-21
Increased vascular smooth muscle contractility in TRPC6-/- mice.
2005-08
Major and trace elements in whole blood of phlebotomized patients with porphyria cutanea tarda.
2005
An inwardly rectifying potassium channel in apical membrane of Calu-3 cells.
2004-11-05
Glycosylation of asparagines 136 and 184 is necessary for the alpha2delta subunit-mediated regulation of voltage-gated Ca2+ channels.
2004-10-08
The renal-specific transporter mediates facilitative transport of organic anions at the brush border membrane of mouse renal tubules.
2004-08
Auxiliary subunit regulation of high-voltage activated calcium channels expressed in mammalian cells.
2004-07
Null mutation of alpha1D Ca2+ channel gene results in deafness but no vestibular defect in mice.
2004-06
Block by extracellular divalent cations of Drosophila big brain channels expressed in Xenopus oocytes.
2004-03
Functional characterization of the L-type Ca2+ channel Cav1.4alpha1 from mouse retina.
2004-02
Elevated levels of ferrimagnetic metals in foodchains supporting the Guam cluster of neurodegeneration: do metal nucleated crystal contaminants [corrected] evoke magnetic fields that initiate the progressive pathogenesis of neurodegeneration?
2004
Appearance of voltage-gated calcium channels following overexpression of ATPase II cDNA in neuronal HN2 cells.
2003-10-07
A novel two-pore domain K+ channel, TRESK, is localized in the spinal cord.
2003-07-25
Five ADNFLE mutations reduce the Ca2+ dependence of the mammalian alpha4beta2 acetylcholine response.
2003-07-01
Plasticity of KIR channels in human smooth muscle cells from internal thoracic artery.
2003-06
Distinct regulation of expressed calcium channels 2.3 in Xenopus oocytes by direct or indirect activation of protein kinase C.
2003-04-11
The functional properties of the human ether-à-go-go-like (HELK2) K+ channel.
2002-08
Inhibitory effects of opioids on voltage-dependent Ca(2+) channels and catecholamine secretion in cultured porcine adrenal chromaffin cells.
2002-06-28
Inhibition of transiently expressed low- and high-voltage-activated calcium channels by trivalent metal cations.
2002-06-01
Guanylin, uroguanylin, and heat-stable euterotoxin activate guanylate cyclase C and/or a pertussis toxin-sensitive G protein in human proximal tubule cells.
2002-05-17
Diacylglycerol activates the influx of extracellular cations in T-lymphocytes independently of intracellular calcium-store depletion and possibly involving endogenous TRP6 gene products.
2002-05-15
The role of endogenous human Trp4 in regulating carbachol-induced calcium oscillations in HEK-293 cells.
2002-04-19
Activation of ion secretion via proteinase-activated receptor-2 in human colon.
2002-02
Cloning of rabbit Kir6.1, SUR2A, and SUR2B: possible candidates for a renal K(ATP) channel.
2002-02
Identification and characterization of novel human Ca(v)2.2 (alpha 1B) calcium channel variants lacking the synaptic protein interaction site.
2002-01-01
Structural requirements of alkanol interaction sites on human alpha 2 beta 4 neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes: effects of linear and branched-chain alkanols.
2002-01
Activation of Na+/K+-ATPase by the serum and glucocorticoid-dependent kinase isoforms.
2002
The involvement of L-type Ca(2+) channels in the relaxant effects of the ATP-sensitive K(+) channel opener ZD6169 on pig urethral smooth muscle.
2001-12
Evidence supporting a role for KCl cotransporter in the thick ascending limb of Henle's loop.
2001-11
Arachidonic acid-induced calcium influx in human platelets. Comparison with the effect of thrombin.
1990-12-01
[The anti-arrhythmia activity of isoteolin (IST)].
1990
Patents

Sample Use Guides

DOSAGE AND ADMINISTRATION Recommended reconstituted oral dose for adults and pediatric patients older than 12 years of age is between 450 mL to 900 mL (9 g to 18 g of barium sulfate, respectively) (2.1) •Pediatric patents younger than 12 years of age adjust reconstituted oral dose based on relative GI volume (2.1) •Must reconstitute supplied powder with water prior to use
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:39:14 GMT 2025
Edited
by admin
on Mon Mar 31 18:39:14 GMT 2025
Record UNII
24GP945V5T
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BA
Preferred Name English
BARIUM
HSDB   MART.   MI   WHO-DD  
Systematic Name English
BARIUM, ELEMENTAL
Common Name English
BARIUM-138
Common Name English
BARIUM 137
Common Name English
BARIUM [MART.]
Common Name English
Barium [WHO-DD]
Common Name English
BARIUM [MI]
Common Name English
BARIUM [HSDB]
Common Name English
Classification Tree Code System Code
LOINC 76653-5
Created by admin on Mon Mar 31 18:39:14 GMT 2025 , Edited by admin on Mon Mar 31 18:39:14 GMT 2025
DSLD 233 (Number of products:27)
Created by admin on Mon Mar 31 18:39:14 GMT 2025 , Edited by admin on Mon Mar 31 18:39:14 GMT 2025
NCI_THESAURUS C1940
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Code System Code Type Description
EPA CompTox
DTXSID8023894
Created by admin on Mon Mar 31 18:39:14 GMT 2025 , Edited by admin on Mon Mar 31 18:39:14 GMT 2025
PRIMARY
RXCUI
1311067
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PRIMARY RxNorm
NCI_THESAURUS
C61475
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PRIMARY
PUBCHEM
5355457
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PRIMARY
FDA UNII
24GP945V5T
Created by admin on Mon Mar 31 18:39:14 GMT 2025 , Edited by admin on Mon Mar 31 18:39:14 GMT 2025
PRIMARY
CAS
7440-39-3
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PRIMARY
EVMPD
SUB12987MIG
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PRIMARY
CAS
15010-01-2
Created by admin on Mon Mar 31 18:39:14 GMT 2025 , Edited by admin on Mon Mar 31 18:39:14 GMT 2025
MAJOR COMPONENT STRUCTURE/SEQUENCE
DAILYMED
24GP945V5T
Created by admin on Mon Mar 31 18:39:14 GMT 2025 , Edited by admin on Mon Mar 31 18:39:14 GMT 2025
PRIMARY
SMS_ID
100000077143
Created by admin on Mon Mar 31 18:39:14 GMT 2025 , Edited by admin on Mon Mar 31 18:39:14 GMT 2025
PRIMARY
WIKIPEDIA
Barium
Created by admin on Mon Mar 31 18:39:14 GMT 2025 , Edited by admin on Mon Mar 31 18:39:14 GMT 2025
PRIMARY
HSDB
4481
Created by admin on Mon Mar 31 18:39:14 GMT 2025 , Edited by admin on Mon Mar 31 18:39:14 GMT 2025
PRIMARY
CHEBI
32595
Created by admin on Mon Mar 31 18:39:14 GMT 2025 , Edited by admin on Mon Mar 31 18:39:14 GMT 2025
PRIMARY
CHEBI
37136
Created by admin on Mon Mar 31 18:39:14 GMT 2025 , Edited by admin on Mon Mar 31 18:39:14 GMT 2025
PRIMARY
DRUG BANK
DB12481
Created by admin on Mon Mar 31 18:39:14 GMT 2025 , Edited by admin on Mon Mar 31 18:39:14 GMT 2025
PRIMARY
CHEBI
32594
Created by admin on Mon Mar 31 18:39:14 GMT 2025 , Edited by admin on Mon Mar 31 18:39:14 GMT 2025
PRIMARY
ECHA (EC/EINECS)
231-149-1
Created by admin on Mon Mar 31 18:39:14 GMT 2025 , Edited by admin on Mon Mar 31 18:39:14 GMT 2025
PRIMARY
CAS
13981-97-0
Created by admin on Mon Mar 31 18:39:14 GMT 2025 , Edited by admin on Mon Mar 31 18:39:14 GMT 2025
ALTERNATIVE
MESH
D001464
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PRIMARY
MERCK INDEX
m2230
Created by admin on Mon Mar 31 18:39:14 GMT 2025 , Edited by admin on Mon Mar 31 18:39:14 GMT 2025
PRIMARY Merck Index
Related Record Type Details
ACTIVE MOIETY