Unknown

Aureonitol inhibited influenza replication 24 h after infection with the A(H3N2) subtype in a dose-dependent fashion, with EC50 values of 30, 100 and 183 nM at MOIs of 0.01, 0.05 and 0.01, respectively . At 48 h after infection, aureonitol's potency was slightly reduced, as the obtained EC50 values were 48, 121 and 201 nM for MOIs of 0.01, 0.05 and 0.1, respectively. For comparison, at 24 post-infection OST presented EC50 values of 12, 30 and 49 nM for MOIs of 0.01, 0.05 and 0.1, respectively. At 48 h after infection, the EC50 concentration for OST also increased slightly to 28, 38 and 56 nM for MOIs of 0.01, 0.05 and 0.1, respectively.