Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C28H29N5O3.ClH |
| Molecular Weight | 520.023 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.C[C@H](CN(C(=O)C1=CC=C(C=C1)C#N)C2=CC=CC=N2)N3CCN(CC3)C4=C5OCCOC5=CC=C4
InChI
InChIKey=GXYZREDEYDFJPT-ZMBIFBSDSA-N
InChI=1S/C28H29N5O3.ClH/c1-21(31-13-15-32(16-14-31)24-5-4-6-25-27(24)36-18-17-35-25)20-33(26-7-2-3-12-30-26)28(34)23-10-8-22(19-29)9-11-23;/h2-12,21H,13-18,20H2,1H3;1H/t21-;/m1./s1
| Molecular Formula | C28H29N5O3 |
| Molecular Weight | 483.5616 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Synthesis and biological evaluation of benzodioxanylpiperazine derivatives as potent serotonin 5-HT(1A) antagonists: the discovery of Lecozotan. | 2005 May 19 |
|
| Lecozotan (SRA-333): a selective serotonin 1A receptor antagonist that enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties. | 2005 Sep |
|
| Progress update: Pharmacological treatment of Alzheimer's disease. | 2007 |
|
| A positron emission tomography study to assess binding of lecozotan, a novel 5-hydroxytryptamine-1A silent antagonist, to brain 5-HT1A receptors in healthy young and elderly subjects, and in patients with Alzheimer's disease. | 2008 Jan |
|
| Bilobalide modulates serotonin-controlled behaviors in the nematode Caenorhabditis elegans. | 2009 Jun 22 |
|
| Safety, tolerability, pharmacokinetics and pharmacodynamics of ascending single and multiple doses of lecozotan in healthy young and elderly subjects. | 2009 Mar |
|
| Drug development for Alzheimer's disease: recent progress. | 2010 Dec |
|
| Acute lecozotan administration increases learning and memory in rats without affecting anxiety or behavioral depression. | 2010 May |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:35:40 GMT 2023
by
admin
on
Fri Dec 15 15:35:40 GMT 2023
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| Record UNII |
23EDE20K1X
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| Record Status |
Validated (UNII)
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| Record Version |
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-
Download
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| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C66885
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23EDE20K1X
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PP-82
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300000044441
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433282-68-9
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C72813
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CHEMBL372205
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DTXSID20195826
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11156648
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ACTIVE MOIETY |