FLUO-3

Details

Stereochemistry	ACHIRAL
Molecular Formula	C36H30Cl2N2O13
Molecular Weight	769.535
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CC=C(N(CC(O)=O)CC(O)=O)C(OCCOC2=CC(=CC=C2N(CC(O)=O)CC(O)=O)C3=C4C=C(Cl)C(=O)C=C4OC5=C3C=C(Cl)C(O)=C5)=C1

InChI

InChIKey=OZLGRUXZXMRXGP-UHFFFAOYSA-N

InChI=1S/C36H30Cl2N2O13/c1-18-2-4-24(39(14-32(43)44)15-33(45)46)30(8-18)51-6-7-52-31-9-19(3-5-25(31)40(16-34(47)48)17-35(49)50)36-20-10-22(37)26(41)12-28(20)53-29-13-27(42)23(38)11-21(29)36/h2-5,8-13,41H,6-7,14-17H2,1H3,(H,43,44)(H,45,46)(H,47,48)(H,49,50)

HIDE SMILES / InChI

Molecular Formula	C36H30Cl2N2O13
Molecular Weight	769.535
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Protective effect of arachidonic acid on glutamate neurotoxicity in rat retinal ganglion cells.	2002-06	12036987
Sphingosine 1-phosphate induces Ca2+ transients and cytoskeletal rearrangement in C2C12 myoblastic cells.	2002-06	11997251
Activation of carp leukocytes by a galactose-binding protein from Aphanomyces piscicida.	2002-06	11906725
Calcium signalling in tissue: diversity and domain-specific integration of individual cell response in salivary glands.	2002-05-01	11956318
Fluorescence detection of plant extracts that affect neuronal voltage-gated Ca2+ channels.	2002-05	11988393
Calcium sparks in human ventricular cardiomyocytes from patients with terminal heart failure.	2002-04	12027382
Mitochondria, calcium and nitric oxide in the apoptotic pathway of esophageal carcinoma cells induced by As2O3.	2002-04	11891533
Effects of phosphocreatine on SR Ca(2+) regulation in isolated saponin-permeabilized rat cardiac myocytes.	2002-03-15	11897848
Mitochondrial calcium ion and oxidative phosphorylation in regenerating rat liver.	2002-03	12051014
Intracellular calcium regulation in inner hair cells from neonatal mice.	2002-03	12027386
4-Bromophenacyl bromide induces Ca2+ influx in human gingival fibroblasts.	2002-03	11912056
Fast Ca2+ signals at mouse inner hair cell synapse: a role for Ca2+-induced Ca2+ release.	2002-02-15	11850498
Ca(2+) dynamics in the lumen of the endoplasmic reticulum in sensory neurons: direct visualization of Ca(2+)-induced Ca(2+) release triggered by physiological Ca(2+) entry.	2002-02-15	11847110
Calcium diffusion coefficient in rod photoreceptor outer segments.	2002-02	11806915
Dual mechanisms of Ca(2+) increases elicited by N-methyl-D-aspartate in immature and mature cultured cortical neurons.	2002-01-15	11782971
Domoic acid neurotoxicity in cultured cerebellar granule neurons is controlled preferentially by the NMDA receptor Ca(2+) influx pathway.	2002-01-04	11743991
Interaction between metabotropic and NMDA subtypes of glutamate receptors in sprout suppression at young synapses.	2002-01-01	11756506
D-AP5 blocks the increase of intracellular free Ca2+ induced by glutamate in isolated cochlear IHCs.	2002-01	11930669
Effects of uniform electric fields on intracellular calcium transients in single cardiac cells.	2002-01	11748049
Real time, confocal imaging of Ca(2+) waves in arterially perfused rat hearts.	2002-01	11744018
Involvement of Ca2+ waves in excitation-contraction coupling of rat atrial cardiomyocytes.	2001-12-28	11833720
Control of Ca(2+) influx by cannabinoid and metabotropic glutamate receptors in rat cerebellar cortex requires K(+) channels.	2001-12-15	11744755
Simultaneous measurement and imaging of intracellular Ca(2+) and H(+) transport in isolated rabbit gastric glands.	2001-12-15	11744751
Expression of inducible nitric oxide synthase depresses beta-adrenergic-stimulated calcium release from the sarcoplasmic reticulum in intact ventricular myocytes.	2001-12-11	11739313
Halothane-induced intracellular calcium release in cholinergic cells.	2001-12-07	11720716
Equine sperm-oocyte interaction: the role of sperm surface hyaluronidase.	2001-12-03	11744273
Iodinated radiographic contrast media inhibit the capacitative calcium entry into smooth muscle cells of the swine renal artery.	2001-12	11753145
Effects of mobile phone type signals on calcium levels within human leukaemic T-cells (Jurkat cells).	2001-12	11747545
Growth factors but not gap junctions play a role in injury-induced Ca2+ waves in epithelial cells.	2001-12	11739651
Activation of connexin-43 hemichannels can elevate [Ca(2+)]i and [Na(+)]i in rabbit ventricular myocytes during metabolic inhibition.	2001-12	11735261
Comparison of the capacitation-like state of cooled boar spermatozoa with true capacitation.	2001-12	11732984
Distinct myoprotective roles of cardiac sarcolemmal and mitochondrial KATP channels during metabolic inhibition and recovery.	2001-12	11726534
Remodeling of synaptic actin induced by photoconductive stimulation.	2001-11-30	11733060
Myocyte function and [Ca 2+ ]i homeostasis during early allogenic heart transplant rejection.	2001-11-27	11726818
A cardiac dihydropyridine receptor II-III loop peptide inhibits resting Ca(2+) sparks in ferret ventricular myocytes.	2001-11-15	11711557
Dynamics of intracellular calcium and free radical production during ischemia in pyramidal neurons.	2001-11-15	11705700
Glutamate induced modulation of free Ca(2+) in isolated inner hair cells of the guinea pig cochlea.	2001-11	11744278
Apoptosis induced by isoliquiritigenin in human gastric cancer MGC-803 cells.	2001-11	11731922
Gap junctional channels regulate acid secretion in the mammalian gastric gland.	2001-10-01	11696856
IP(3) receptor function and localization in myotubes: an unexplored Ca(2+) signaling pathway in skeletal muscle.	2001-10	11707519
Overexpression of the human angiotensin II type 1 receptor in the rat heart augments load induced cardiac hypertrophy.	2001-10	11692158
Effects of propofol on mitochondrial function and intracellular calcium shift in bovine aortic endothelial model.	2001-09	11688101
Long-term depolarization regulates the alpha1s, subunit of skeletal muscle Ca2+ channels and the amplitude of L-type Ca2+ currents.	2001-09	11680621
Inhibitory role of GDP on saikosaponin (I) stimulated enzymes secretion and rising of [Ca2+]i in rat pancreatic acini.	2001-07	11749835
[Phosphorylation of gap junction gene connexin 43 protein and dissociated calcium in HeLa cell line by all-trans-retinoic acid].	2001-04	11783369
[Effect of calcium hydroxide on human pulp cell intracellular calcium ion in vitro].	2001-03	11812323
[Calcium oscillations induced by lindane in peritoneal macrophages of mice: control by the maturation stage of the macrophage].	2001	11833466
Functional analysis of a frame-shift mutant of the dihydropyridine receptor pore subunit (alpha1S) expressing two complementary protein fragments.	2001	11806762
Early expression of glycine and GABA(A) receptors in developing spinal cord neurons. Effects on neurite outgrowth.	2001	11738262
Deciphering the plasma membrane hallmarks of apoptotic cells: phosphatidylserine transverse redistribution and calcium entry.	2001	11701087

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:53:46 GMT 2025` Edited by `admin` on `Mon Mar 31 22:53:46 GMT 2025`
Record UNII	23D4W0B50Y
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FLUO-3

Common Name

English

GLYCINE, N-(2-(2-(2-(BIS(CARBOXYMETHYL)AMINO)-5-(2,7-DICHLORO-6-HYDROXY-3-OXO-3H-XANTHENE-9-YL)PHENOXY)ETHOXY)-4-METHYLPHENYL)-N-(CARBOXYMETHYL)-

Preferred Name

English

Code System Code Type Description

WIKIPEDIA

Fluo-3