In preclinical experiments on monkeys, SKF-83822 was administered intravenously at 0.08 mg/kg.

Male rats weighing 225-300 g were decapitated, and the striata were dissected on ice, then gently the tissues were gently homogenized at 0°C in 50 mM Tris-maleate buffer (pH 7.4) containing 2 M EGTA. Aliquots of the homogenate were incubated in medium containing Tris-maleate buffer and SKF-83822. Reaction was started by adding [14C]ATP and shaking at 30°C. After 3 min the reaction was terminated in a boiling water bath, the [14C]cyclic AMP formed was separated from unreacted [14C]ATP using alumina and cation exchange resin columns, and the [14C]cyclic AMP content was measured by liquid scintillation counting.