DescriptionCurator's Comment: Description was created based on several sources, including https://www.ulprospector.com/en/eu/PersonalCare/Detail/1409/75456/Arlacel-165 and
https://books.google.ru/books?id=C4Cr8dHupVsC&pg=PA273&lpg=PA273&dq=MONOSTEARIN+approved&source=bl&ots=3U3S0OCvrn&sig=1aCs8tLlzy0KbTA2_K9ZPuMG1M8&hl=en&sa=X&ved=0ahUKEwjBpvuD_Z3PAhWBKywKHY0oDMs4ChDoAQgpMAU#v=onepage&q=MONOSTEARIN%20approved&f=false, Retrieved from Handbook of Fillers, Extenders, and Diluents
edited by Michael Ash, Irene Ash, p. 273
Curator's Comment: Description was created based on several sources, including https://www.ulprospector.com/en/eu/PersonalCare/Detail/1409/75456/Arlacel-165 and
https://books.google.ru/books?id=C4Cr8dHupVsC&pg=PA273&lpg=PA273&dq=MONOSTEARIN+approved&source=bl&ots=3U3S0OCvrn&sig=1aCs8tLlzy0KbTA2_K9ZPuMG1M8&hl=en&sa=X&ved=0ahUKEwjBpvuD_Z3PAhWBKywKHY0oDMs4ChDoAQgpMAU#v=onepage&q=MONOSTEARIN%20approved&f=false, Retrieved from Handbook of Fillers, Extenders, and Diluents
edited by Michael Ash, Irene Ash, p. 273
Glyceryl 1-stearate (Glycerol monostearate), commonly known as GMS, is an organic molecule used as an emulsifier. GMS is a white, odorless, and sweet-tasting flaky powder that is hygroscopic. It is a glycerol ester of stearicacid. It occurs naturally in the body as a product of the breakdown of fats by pancreatic lipase, and is also found in fatty foods. GMS is a food additive used as a thickening, emulsifying, anti-caking, and preservative agent; an emulsifying agent for oils, waxes, and solvents; a protective coating for hygroscopic powders; a solidifier and control release agent in pharmaceuticals; and a resin lubricant. It is also used in cosmetics and hair care products. Used in antiperspirants and deodorants, baby care, body care, facial care, sun care, conditioners, facial make-up, creams and lotions-skin care, sprayable emulsions, feet, hands and nails, self-tanning, nail grooming and color cosmetics. GMS is largely used in baking preparations to add "body" to the food. It is responsible for giving ice cream and whipped cream its smooth texture. It is sometimes used as an anti-staling agent in bread. Glycerol 1-stearate is affirmed by FDA as GRAS.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL230 Sources: http://www.ncbi.nlm.nih.gov/pubmed/18487046 |
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Target ID: CHEMBL3474 Sources: http://www.ncbi.nlm.nih.gov/pubmed/18487046 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Preventing | Fresh Med Solution Approved UseTemporarily protects and helps relieve chapped or cracked skin. Helps protect from the drying effects of wind and cold weather Launch Date2011 |
PubMed
Title | Date | PubMed |
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Monoglycerides from the brown alga Sargassum sagamianum: Isolation, synthesis, and biological activity. | 2008 Jun 15 |
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Doxycycline hyclate-loaded bleached shellac in situ forming microparticle for intraperiodontal pocket local delivery. | 2016 Oct 10 |
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Lipid Nanocarrier-Mediated Drug Delivery System to Enhance the Oral Bioavailability of Rifabutin. | 2017 Apr |
Patents
Sample Use Guides
In Vitro Use Guide
Sources: http://www.ncbi.nlm.nih.gov/pubmed/18487046
Glyceryl 1-stearate inhibited 16.5% COX2 at 50 uM
Substance Class |
Mixture
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Classification Tree | Code System | Code | ||
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JECFA EVALUATION |
GLYCEROL MONOSTEARATE
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NCI_THESAURUS |
C83486
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DSLD |
3945 (Number of products:103)
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21 CFR 175.210
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21 CFR 184.1324
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31566-31-1
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DB11250
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1311155
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C80900
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GLYCERYL MONOSTEARATE
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PRIMARY | Description: A white or yellowish white, hard waxy mass or unctuous powder or flakes; odourless or slight, agreeable, fatty odour. Solubility: Practically insoluble in water; soluble in ether R, benzene R, and ethanol (~750 g/l) TS at 60 ?C. Category: Emulsifying agent; cream and ointment base. Storage: Glyceryl monostearate should be kept in a tightly closed container, protected from light. Additional information: Glyceryl monostearate may contain a suitable antioxidant. Self-emulsifying glyceryl monostearate contains additional emulsifying agents. Definition: Glyceryl monostearate is a mixture of mono-, di- and triglycerides of stearic and palmitic acids. Glyceryl monostearate contains not less than the equivalent of 35.0% of monoglycerides, calculated as C20H40O4, and not morethan the equivalent of 6.0% of free glycerol. | ||
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GLYCEROL MONOSTEARATE
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234-325-6
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