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Description

Glyceryl 1-stearate (Glycerol monostearate), commonly known as GMS, is an organic molecule used as an emulsifier. GMS is a white, odorless, and sweet-tasting flaky powder that is hygroscopic. It is a glycerol ester of stearicacid. It occurs naturally in the body as a product of the breakdown of fats by pancreatic lipase, and is also found in fatty foods. GMS is a food additive used as a thickening, emulsifying, anti-caking, and preservative agent; an emulsifying agent for oils, waxes, and solvents; a protective coating for hygroscopic powders; a solidifier and control release agent in pharmaceuticals; and a resin lubricant. It is also used in cosmetics and hair care products. Used in antiperspirants and deodorants, baby care, body care, facial care, sun care, conditioners, facial make-up, creams and lotions-skin care, sprayable emulsions, feet, hands and nails, self-tanning, nail grooming and color cosmetics. GMS is largely used in baking preparations to add "body" to the food. It is responsible for giving ice cream and whipped cream its smooth texture. It is sometimes used as an anti-staling agent in bread. Glycerol 1-stearate is affirmed by FDA as GRAS.

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Fresh Med Solution
PubMed

PubMed

TitleDatePubMed
Monoglycerides from the brown alga Sargassum sagamianum: Isolation, synthesis, and biological activity.
2008 Jun 15
Doxycycline hyclate-loaded bleached shellac in situ forming microparticle for intraperiodontal pocket local delivery.
2016 Oct 10
Lipid Nanocarrier-Mediated Drug Delivery System to Enhance the Oral Bioavailability of Rifabutin.
2017 Apr
Patents

Sample Use Guides

In Vitro Use Guide
Glyceryl 1-stearate inhibited 16.5% COX2 at 50 uM
Substance Class Mixture
Created
by admin
on Mon Oct 21 19:54:41 UTC 2019
Edited
by admin
on Mon Oct 21 19:54:41 UTC 2019
Record UNII
230OU9XXE4
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GLYCERYL MONOSTEARATE
FCC   FHFI   II   MI   VANDF   WHO-DD   WHO-IP  
Common Name English
GLYCERYL STEARATE [VANDF]
Common Name English
GLYCERYL STEARATE
II   INCI   VANDF  
INCI  
Official Name English
LONZEST GMS
Brand Name English
OCTADECANOIC ACID, MONOESTER WITH 1,2,3-PROPANETRIOL
Common Name English
MONOGLYCERIDES, C16-18
Common Name English
GLYCEROLI MONOSTEARAS [WHO-IP LATIN]
Common Name English
STEARIN, MONO-
Common Name English
GLYCERYL MONOSTEARATE [WHO-IP]
Common Name English
GLYCERYL MONOSTEARATE [FHFI]
Common Name English
STEARIC ACID, MONOESTER WITH GLYCEROL
Common Name English
NIKKOL MGS-A
Brand Name English
GLYCERYL MONOSTEARATE [II]
Common Name English
CERASYNT-SD [VANDF]
Common Name English
IMWITOR 491
Brand Name English
CERASYNT-SD
VANDF  
Common Name English
GLYCERYL MONOSTEARATE [FCC]
Common Name English
FEMA NO. 2527
Code English
GLYCERYL STEARATE [INCI]
Common Name English
CUTINA GMS
Brand Name English
STEARIN
Common Name English
GLYCERIDES, C16-18 MONO-
Common Name English
CREMOPHOR GMSK
Brand Name English
GLYCERYL MONOSTEARATE [WHO-DD]
Common Name English
GLYCERYL MONOPALMITOSTEARATE
Common Name English
GLYCERYL STEARATE [II]
Common Name English
GLYCERYL MONOSTEARATE [VANDF]
Common Name English
CITHROL GMS 0400
Common Name English
CERASYNT SD
Brand Name English
GLYCEROL MONOSTEARATE
Common Name English
SORBON MG-100
Brand Name English
GLYCERYL MONOSTEARATE [MI]
Common Name English
GLYCEROL STEARATE
Common Name English
MONOSTEARIN
Common Name English
Classification Tree Code System Code
JECFA EVALUATION GLYCEROL MONOSTEARATE
Created by admin on Mon Oct 21 19:54:42 UTC 2019 , Edited by admin on Mon Oct 21 19:54:42 UTC 2019
NCI_THESAURUS C83486
Created by admin on Mon Oct 21 19:54:42 UTC 2019 , Edited by admin on Mon Oct 21 19:54:42 UTC 2019
CFR 21 CFR 175.210
Created by admin on Mon Oct 21 19:54:42 UTC 2019 , Edited by admin on Mon Oct 21 19:54:42 UTC 2019
CFR 21 CFR 184.1324
Created by admin on Mon Oct 21 19:54:42 UTC 2019 , Edited by admin on Mon Oct 21 19:54:42 UTC 2019
Code System Code Type Description
CAS
31566-31-1
Created by admin on Mon Oct 21 19:54:42 UTC 2019 , Edited by admin on Mon Oct 21 19:54:42 UTC 2019
ALTERNATIVE
RXCUI
1311155
Created by admin on Mon Oct 21 19:54:42 UTC 2019 , Edited by admin on Mon Oct 21 19:54:42 UTC 2019
ALTERNATIVE
NCI_THESAURUS
C80900
Created by admin on Mon Oct 21 19:54:42 UTC 2019 , Edited by admin on Mon Oct 21 19:54:42 UTC 2019
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
GLYCERYL MONOSTEARATE
Created by admin on Mon Oct 21 19:54:42 UTC 2019 , Edited by admin on Mon Oct 21 19:54:42 UTC 2019
PRIMARY Description: A white or yellowish white, hard waxy mass or unctuous powder or flakes; odourless or slight, agreeable, fatty odour. Solubility: Practically insoluble in water; soluble in ether R, benzene R, and ethanol (~750 g/l) TS at 60 ?C. Category: Emulsifying agent; cream and ointment base. Storage: Glyceryl monostearate should be kept in a tightly closed container, protected from light. Additional information: Glyceryl monostearate may contain a suitable antioxidant. Self-emulsifying glyceryl monostearate contains additional emulsifying agents. Definition: Glyceryl monostearate is a mixture of mono-, di- and triglycerides of stearic and palmitic acids. Glyceryl monostearate contains not less than the equivalent of 35.0% of monoglycerides, calculated as C20H40O4, and not morethan the equivalent of 6.0% of free glycerol.
EPA CompTox
11099-07-3
Created by admin on Mon Oct 21 19:54:42 UTC 2019 , Edited by admin on Mon Oct 21 19:54:42 UTC 2019
PRIMARY
RXCUI
1311165
Created by admin on Mon Oct 21 19:54:42 UTC 2019 , Edited by admin on Mon Oct 21 19:54:42 UTC 2019
PRIMARY
ECHA (EC/EINECS)
250-705-4
Created by admin on Mon Oct 21 19:54:42 UTC 2019 , Edited by admin on Mon Oct 21 19:54:42 UTC 2019
PRIMARY
EVMPD
SUB28862
Created by admin on Mon Oct 21 19:54:42 UTC 2019 , Edited by admin on Mon Oct 21 19:54:42 UTC 2019
PRIMARY
MERCK INDEX
M5794
Created by admin on Mon Oct 21 19:54:42 UTC 2019 , Edited by admin on Mon Oct 21 19:54:42 UTC 2019
PRIMARY Merck Index
EVMPD
SUB107783
Created by admin on Mon Oct 21 19:54:42 UTC 2019 , Edited by admin on Mon Oct 21 19:54:42 UTC 2019
ALTERNATIVE
WIKIPEDIA
GLYCEROL MONOSTEARATE
Created by admin on Mon Oct 21 19:54:42 UTC 2019 , Edited by admin on Mon Oct 21 19:54:42 UTC 2019
PRIMARY
CAS
11099-07-3
Created by admin on Mon Oct 21 19:54:42 UTC 2019 , Edited by admin on Mon Oct 21 19:54:42 UTC 2019
NON-SPECIFIC STOICHIOMETRY
CAS
91052-47-0
Created by admin on Mon Oct 21 19:54:42 UTC 2019 , Edited by admin on Mon Oct 21 19:54:42 UTC 2019
PRIMARY
EVMPD
SUB15930MIG
Created by admin on Mon Oct 21 19:54:42 UTC 2019 , Edited by admin on Mon Oct 21 19:54:42 UTC 2019
PRIMARY
ECHA (EC/EINECS)
234-325-6
Created by admin on Mon Oct 21 19:54:42 UTC 2019 , Edited by admin on Mon Oct 21 19:54:42 UTC 2019
NON-SPECIFIC STOICHIOMETRY
EVMPD
SUB12509MIG
Created by admin on Mon Oct 21 19:54:42 UTC 2019 , Edited by admin on Mon Oct 21 19:54:42 UTC 2019
PRIMARY
ChEMBL
CHEMBL255696
Created by admin on Mon Oct 21 19:54:42 UTC 2019 , Edited by admin on Mon Oct 21 19:54:42 UTC 2019
PRIMARY
MESH
C048159
Created by admin on Mon Oct 21 19:54:42 UTC 2019 , Edited by admin on Mon Oct 21 19:54:42 UTC 2019
PRIMARY
EVMPD
SUB177441
Created by admin on Mon Oct 21 19:54:42 UTC 2019 , Edited by admin on Mon Oct 21 19:54:42 UTC 2019
PRIMARY
Definition References