Pomlucabtagene autoleucel

Investigational

Approval Year

Substance Class	Structurally Diverse
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	BLOOD
Fraction Material Type	CELL
Fraction Name	CD3+ enriched T lymphocytes
Record UNII	22TCU7HE9E
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Pomlucabtagene autoleucel

Official Name

English

autologous T lymphocytes obtained from peripheral blood mononuclear cells by leukapheresis, transduced with a self-inactivating, non-replicating murine stem cell virus (MSCV) vector, encoding a chimeric antigen receptor (CAR) targeting human ganglioside

Common Name

English

pomlucabtagene autoleucel [INN]

Common Name

English

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Code System

Code

Type

Description

FDA UNII

22TCU7HE9E

PRIMARY

INN

12254

PRIMARY

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Related Record

Type

Details


					X8HRQ6G9HF

GANGLIOSIDE M2

TARGET->CYTOTOXIC T-CELL

Amount:


					R4QQ5YK78D

C-C MOTIF CHEMOKINE 19

EXPRESSED PROTEIN->VECTOR

Amount:


					418XB47Y71

INTERLEUKIN-7 HUMAN RECOMBINANT

EXPRESSED PROTEIN->VECTOR

Amount:

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Related Record

Type

Details


					22TCU7HE9E

Pomlucabtagene autoleucel

ACTIVE MOIETY

Comments:

cell-based gene therapy (antineoplastic)

Amount:

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Agent Modifications

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Modification Process	Modification Role	Modification Type	Fragment Name	Fragment ID
CULTURE	EXPANSION	BIOLOGICAL	HUMAN INTERLEUKIN-2	FNO32LO217
LENTIVIRAL TRANSFECTION	TRANSFECTION	BIOLOGICAL	Pomlucabtagene autoleucel retroviral vector	6TE68QHJ9Q
CULTURE	ACTIVATOR	BIOLOGICAL	HUMAN INTERLEUKIN-2	FNO32LO217

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Structural Modifications

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Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
INSERTED GENE EXPRESSION VECTOR					UNSPECIFIED SUBSTANCE	f7697a39 (not in database)
VECTOR EXPRESSED PROTEIN					Pomlucabtagene autoleucel CAR-T receptor	C2Z887B3BP

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Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
ENHANCED ACTIVATION	BIOLOGICAL		`P050J5FWC5` INTERFERON GAMMA