U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
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Approval Year

Substance Class Protein
Created
by admin
on Wed Apr 02 02:02:22 GMT 2025
Edited
by admin
on Wed Apr 02 02:02:22 GMT 2025
Protein Sub Type
Sequence Type COMPLETE
Record UNII
22Q832K2UN
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CATECHOL O-METHYLTRANSFERASE
Common Name English
COMT
Preferred Name English
Catechol-O-methyl transferase
Common Name English
Code System Code Type Description
FDA UNII
22Q832K2UN
Created by admin on Wed Apr 02 02:02:22 GMT 2025 , Edited by admin on Wed Apr 02 02:02:22 GMT 2025
PRIMARY
PHAROS
P21964
Created by admin on Wed Apr 02 02:02:22 GMT 2025 , Edited by admin on Wed Apr 02 02:02:22 GMT 2025
PRIMARY
UNIPROT
P21964
Created by admin on Wed Apr 02 02:02:22 GMT 2025 , Edited by admin on Wed Apr 02 02:02:22 GMT 2025
PRIMARY
Related Record Type Details
INHIBITOR -> TARGET
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
INHIBITOR -> TARGET
RADIOLIGAND->TARGET
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
INHIBITOR -> TARGET
Opicapone is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT).
INHIBITOR -> TARGET
SUBSTRATE -> METABOLIC ENZYME
INHIBITOR -> TARGET
SUBSTRATE -> METABOLIC ENZYME

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_267] DEXFOSFOSERINE VI4F0K069V
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL
Molecular Formula CHEMICAL