MOLYBDENUM TRIOXIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	MoO3
Molecular Weight	143.94
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O=[Mo](=O)=O

InChI

InChIKey=JKQOBWVOAYFWKG-UHFFFAOYSA-N

InChI=1S/Mo.3O

HIDE SMILES / InChI

Molecular Formula	MoO3
Molecular Weight	143.94
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12587014 | https://www.ncbi.nlm.nih.gov/pubmed/24417578

Molybdenum trioxide (MoO3) is used primarily as an additive to steel and corrosion-resistant alloys. It is also used as a chemical intermediate for molybdenum products; an industrial catalyst; a pigment; a crop nutrient; components of glass, ceramics, and enamels; a flame retardant for polyester and polyvinyl chloride resins; and a reagent in chemical analyses. Molybdenum trioxide was nominated by the NCI for toxicity and carcinogenicity studies as a representative inorganic molybdenum compound. In addition some studies were done, showing the potential utility of MoO3 for treating metastatic cancer cells, which might enable advancements in cancer therapy.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
Human NAD(P)H:quinone oxidoreductase induction in human hepatoma cells after exposure to industrial acrylates, phenolics, and metals.	1997 Feb	9029048
Toxicity of nano molybdenum trioxide toward invasive breast cancer cells.	2014 Feb 26	24417578

Patents

Sample Use Guides

In Vivo Use Guide

toxicity in rats: molybdenum trioxide by inhalation at concentrations of 0, 10, 30, or 100 mg/m(3). Rats were exposed for 6 hours per day, 5 days per week, for 106 weeks. toxicity in mice: molybdenum trioxide by inhalation at concentrations of 0, 1, 3, 10, 30, or 100 mg/m(3) for 6.5 hours per day, 5 days per week, for 13 weeks

Route of Administration: Respiratory

In Vitro Use Guide

It was investigated the cytotoxicity of molybdenum trioxide (MoO3) nanoplates toward invasive breast cancer iMCF-7 cells by analyzing morphological changes and performing Western blot and flow cytometry analyses. It was discovered, that MoO3 exposure induced apoptosis and generated reactive oxygen species (ROS) in iMCF-7 cells.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:46:05 GMT 2023` Edited by `admin` on `Fri Dec 15 17:46:05 GMT 2023`
Record UNII	22FQ3F03YS
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MOLYBDENUM TRIOXIDE

Systematic Name

English

Molybdenum trioxide [WHO-DD]

Common Name

English

MOLYBDENUM(VI) OXIDE

Systematic Name

English

MOLYBDIC ANHYDRIDE

Common Name

English

MOLYBDENUM TRIOXIDE [MI]

Common Name

English

MOLYBDENUM TRIOXIDE [IARC]

Common Name

English

MOLYBDENUM TRIOXIDE [HSDB]

Common Name

English

NSC-215191

Code

English

MOLYBDENUM OXIDE (MOO3)

Common Name

English

Code System Code Type Description

PUBCHEM

14802