SEMUSTINE, CIS-

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H18ClN3O2
Molecular Weight	247.722
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@H]1CC[C@H](CC1)NC(=O)N(CCCl)N=O

InChI

InChIKey=FVLVBPDQNARYJU-DTORHVGOSA-N

InChI=1S/C10H18ClN3O2/c1-8-2-4-9(5-3-8)12-10(15)14(13-16)7-6-11/h8-9H,2-7H2,1H3,(H,12,15)/t8-,9+

HIDE SMILES / InChI

Molecular Formula	C10H18ClN3O2
Molecular Weight	247.722
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Colorectal cancer 1 Target ID: map05210 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7113964	Inhibitor 8504

PubMed

Title	Date	PubMed
Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.	2011-07-14	21599003
Interstitial chemotherapy with biodegradable BCNU (Gliadel) wafers in the treatment of malignant gliomas.	2007-10	18472995
Randomized trial of adjuvant therapy in colon carcinoma: 10-year results of NSABP protocol C-01.	2004-08-04	15292384
1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea.	2004	21089826
1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (MeCCNU).	2002	15320318
Anticancer drug-induced kidney disorders.	2001-01	11219485
Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias.	2000-05	10815900
Nephrotoxicity induced by cancer chemotherapy with special emphasis on cisplatin toxicity.	1986-11	3538860
Comparative nephrotoxicity of 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea (MeCCNU) and chlorozotocin: functional-structural correlations in the Fischer 344 rat.	1986-03-15	2937179
Chemical cholecystitis after intrahepatic chemotherapy. The case for prophylactic cholecystectomy during pump placement.	1986-03	2935378
Enhancement by electron-affinic agents of the therapeutic effects of cytotoxic agents against the KHT tumor: structure-activity relationships.	1982-03-01	7107385
Chemotherapeutic effects of some alkylating derivatives of nitrosourea on the development of tumors transplacentally induced in rats by ENU.	1976-01-31	175631
A phase 2 evaluation of 1-(2-chloroethyl)-3-(4- methylcyclohexyl)-1-nitrosourea (NSC 95441) in patients with advanced breast cancer.	1974-01	4809462

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:20:52 GMT 2025` Edited by `admin` on `Mon Mar 31 19:20:52 GMT 2025`
Record UNII	2281H4FBL9
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

SEMUSTINE, CIS-

Common Name

English

NSC-135091

Preferred Name

English

UREA, N-(2-CHLOROETHYL)-N'-(4-METHYLCYCLOHEXYL)-N-NITROSO-, CIS-

Common Name

English

1-(2-CHLOROETHYL)-3-(4-METHYLCYCLOHEXYL)-1-NITROSOUREA,, CIS-

Common Name

English

Code System Code Type Description

FDA UNII

2281H4FBL9

Created by admin on Mon Mar 31 19:20:52 GMT 2025 , Edited by admin on Mon Mar 31 19:20:52 GMT 2025

PRIMARY

CAS

33185-87-4

Created by admin on Mon Mar 31 19:20:52 GMT 2025 , Edited by admin on Mon Mar 31 19:20:52 GMT 2025

PRIMARY

EPA CompTox

DTXSID301170045

Created by admin on Mon Mar 31 19:20:52 GMT 2025 , Edited by admin on Mon Mar 31 19:20:52 GMT 2025

PRIMARY

NSC

135091

Created by admin on Mon Mar 31 19:20:52 GMT 2025 , Edited by admin on Mon Mar 31 19:20:52 GMT 2025

PRIMARY