RISLENEMDAZ, (+)-

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C19H23FN4O2
Molecular Weight	358.4099
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CC=C(COC(=O)N2CC[C@@H](CNC3=NC=CC=N3)[C@@H](F)C2)C=C1

InChI

InChIKey=RECBFDWSXWAXHY-IRXDYDNUSA-N

InChI=1S/C19H23FN4O2/c1-14-3-5-15(6-4-14)13-26-19(25)24-10-7-16(17(20)12-24)11-23-18-21-8-2-9-22-18/h2-6,8-9,16-17H,7,10-13H2,1H3,(H,21,22,23)/t16-,17-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C19H23FN4O2
Molecular Weight	358.4099
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://pubchem.ncbi.nlm.nih.gov/compound/11462488
Curator's Comment: Description was created using several sources including: https://www.google.com/patents/US7592360|https://www.ncbi.nlm.nih.gov/pubmed/19491335|http://www.drugdevelopment-technology.com/news/newscerecors-phase-ii-clinical-trial-of-cerc-301-to-treat-mdd-fails-to-meet-primary-endpoint-5683370

MK-0657, (+)-, a MK 0657 - cis-(+)-isomer, relates to N-substituted nonarylheterocyclic compounds, N-methyl-D-aspartate subunit 2B (NMDA NR2B) antagonists which were developed by Merck as a candidate drugs for the treatment of Parkinson's disease and pain. There are no studies on MK 0657 - cis-(+)-isomer activity.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:45:41 GMT 2025` Edited by `admin` on `Mon Mar 31 21:45:41 GMT 2025`
Record UNII	22549Y08ZR
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

RISLENEMDAZ, (+)-

Official Name

English

MK-0657, (+)-

Preferred Name

English

1-PIPERIDINECARBOXYLIC ACID, 3-FLUORO-4-((2-PYRIMIDINYLAMINO)METHYL)-, (4-METHYLPHENYL)METHYL ESTER, (3R,4S)-

Systematic Name

English

Code System Code Type Description

FDA UNII

22549Y08ZR

Created by admin on Mon Mar 31 21:45:41 GMT 2025 , Edited by admin on Mon Mar 31 21:45:41 GMT 2025

PRIMARY

PUBCHEM

11462488

Created by admin on Mon Mar 31 21:45:41 GMT 2025 , Edited by admin on Mon Mar 31 21:45:41 GMT 2025

PRIMARY

CAS

808732-99-2

Created by admin on Mon Mar 31 21:45:41 GMT 2025 , Edited by admin on Mon Mar 31 21:45:41 GMT 2025

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