Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C6H9NO6 |
Molecular Weight | 191.1388 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]12OC[C@H](O[N+]([O-])=O)[C@@]1([H])OC[C@H]2O
InChI
InChIKey=YWXYYJSYQOXTPL-JGWLITMVSA-N
InChI=1S/C6H9NO6/c8-3-1-11-6-4(13-7(9)10)2-12-5(3)6/h3-6,8H,1-2H2/t3-,4+,5-,6-/m1/s1
Molecular Formula | C6H9NO6 |
Molecular Weight | 191.1388 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2111348 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2895614 |
0.75 mM [EC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
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Primary | Unknown Approved UseUnknown |
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Primary | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
---|---|---|
Delayed asystolic cardiac arrest after diltiazem overdose; resuscitation with high dose intravenous calcium. | 2002 Jul |
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Effect of large volume injection of hydrophobic solvents on the retention of less hydrophobic pharmaceutical solutes in RP-LC. | 2008 Sep |
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Death following bilateral complete Achilles tendon rupture in a patient on fluoroquinolone therapy: a case report. | 2009 Jan 6 |
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Pentaerythritol tetranitrate improves angiotensin II-induced vascular dysfunction via induction of heme oxygenase-1. | 2010 Apr |
|
Differences between nitrates: role of isosorbide 2-mononitrate. | 2010 Jul |
Sample Use Guides
Isosorbide 5-mononitrate (IS-5-MN) and isosorbide 2-mononitrate (IS-2-MN) kinetics were studied in two groups of young healthy subjects after intravenous injection of 5 mg of both and after oral doses of 20 mg of IS-2-MN and 10, 15, and 20 mg of IS-5-MN.
Route of Administration:
Other
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6498631
2-isosorbide mononitrate (2-ISMN) is able to relax phenylephrine-contracted rabbit aortic rings (ED50, 1.8 uM)
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 07:59:07 UTC 2023
by
admin
on
Sat Dec 16 07:59:07 UTC 2023
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Record UNII |
21BMF8FI0K
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Record Status |
Validated (UNII)
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Record Version |
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SUB35553
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