Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C15H26O |
| Molecular Weight | 222.3663 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]12CC(C)(C)[C@]1([H])CC[C@]3(C)CCC[C@@]2(O)C3
InChI
InChIKey=FUQAYSQLAOJBBC-PAPYEOQZSA-N
InChI=1S/C15H26O/c1-13(2)9-12-11(13)5-8-14(3)6-4-7-15(12,16)10-14/h11-12,16H,4-10H2,1-3H3/t11-,12+,14+,15-/m1/s1
| Molecular Formula | C15H26O |
| Molecular Weight | 222.3663 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/28891397 | https://www.ncbi.nlm.nih.gov/pubmed/28724695
Curator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/28891397 | https://www.ncbi.nlm.nih.gov/pubmed/28724695
beta-Caryophyllene alcohol is a fragrance ingredient used in decorative cosmetics, fine fragrances, shampoos, toilet soaps and other toiletries as well as in non-cosmetic products such as household cleaners and detergents. Its use worldwide is in the region of <0.1 metric tonnes per annum. In vivo studies found that b-Caryophyllene alcohol significantly inhibited asthma induced by histamine and acetylcholine in guinea pigs with the efficacy lasting for at least 6 hours and with the potency equivalent to aminophylline. Inhibition of airway inflammation and scavenging of free radical and reactive oxygen species was one of the mechanisms of anti-asthmatic action
Originator
Approval Year
Sample Use Guides
For intravenous (i.v.) pharmacokinetic studies, the rats were treated with low (5 mg/kg), middle (10 mg/kg) and high (20 mg/kg) doses of b-Caryophyllene alcohol solution (in 5% glucose containing 30% ethanol as solubilizer) via tail vein.
For oral pharmacokinetic studies, the rats received an intragastric (i.g.) dose (100 mg/kg) of b-Caryophyllene alcohol solution, suspension (in 0.5% sodium carboxy-methylcellulose) and PEG formulation.
Route of Administration:
Other
S. griseus strain S4–7 was used for activity evaluation. To test antifungal activity, the volatile mixture concentration of S4–7 was prepared at 5 mg ml21 and 40, 20 and 10 ml samples used. The synthetic caryolan-1-ol was diluted to 0.075, 0.038, 0.019, 0.009 and 0.005 mmol ml21. A paper disc (8 mm) treated with a fraction of volatiles mixture or synthesized caryolan-1-ol was put in the lid of the Petri dish cover and B. cinerea was grown on the agar at 278C. After 4 days of incubation, mycelial growth was measured.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:53:47 GMT 2023
by
admin
on
Sat Dec 16 08:53:47 GMT 2023
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| Record UNII |
2192AHI681
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| Record Status |
Validated (UNII)
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| Record Version |
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261-237-5
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58404-89-0
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2192AHI681
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admin on Sat Dec 16 08:53:47 GMT 2023 , Edited by admin on Sat Dec 16 08:53:47 GMT 2023
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