OPUCOLIMAB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 06:32:30 GMT 2025` Edited by `admin` on `Wed Apr 02 06:32:30 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Record UNII	20ZE3P16HV
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

opucolimab [INN]

Preferred Name

English

OPUCOLIMAB

Official Name

English

IMMUNOGLOBULIN G1, ANTI-(HUMAN PROGRAMMED DEATH-LIGAND 1) (HUMAN MONOCLONAL HLX20 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN MONOCLONAL HLX20 .LAMBDA.-CHAIN, DIMER

Common Name

English

IMMUNOGLOBULIN G1-LAMBDA, ANTI-(HOMO SAPIENS CD274 (PROGRAMMED DEATH LIGAND 1, PDL1, PD-L1, B7 HOMOLOG 1, B7H1)), MONOCLONAL ANTIBODYGAMMA1 HEAVY CHAIN (1-453) (VH (HOMO SAPIENS IGHV3-21*01 (94.9%)-(IGHD)-IGHJ3*01 (93.3%)) (8.8.16) (1-123)-HOMO SAPIENS I

Common Name

English

Code System Code Type Description

INN

11310

Created by admin on Wed Apr 02 06:32:30 GMT 2025 , Edited by admin on Wed Apr 02 06:32:30 GMT 2025

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NCI_THESAURUS

C165270

Created by admin on Wed Apr 02 06:32:30 GMT 2025 , Edited by admin on Wed Apr 02 06:32:30 GMT 2025

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CAS

2251771-79-4

Created by admin on Wed Apr 02 06:32:30 GMT 2025 , Edited by admin on Wed Apr 02 06:32:30 GMT 2025

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SMS_ID

300000024135

Created by admin on Wed Apr 02 06:32:30 GMT 2025 , Edited by admin on Wed Apr 02 06:32:30 GMT 2025

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FDA UNII

20ZE3P16HV

Created by admin on Wed Apr 02 06:32:30 GMT 2025 , Edited by admin on Wed Apr 02 06:32:30 GMT 2025

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From	To
1_22	1_96
2_22	2_96
2_150	2_206
2_226	4_214
2_267	2_327
1_150	1_206
2_373	2_431
3_22	3_89
3_137	3_196
4_22	4_89
4_137	4_196
1_226	3_214
1_232	2_232
1_235	2_235
1_267	1_327
1_373	1_431

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
C	1_303
C	2_303

Related Record Type Details


					L4766ELH5T

PROGRAMMED CELL DEATH 1 LIGAND 1

TARGET -> INHIBITOR

Related Record Type Details


					20ZE3P16HV

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_453] [2_453]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL