NICLOSAMIDE MONOHYDRATE

US Previously Marketed

Details

Stereochemistry	ACHIRAL
Molecular Formula	C13H8Cl2N2O4.H2O
Molecular Weight	345.135
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O.OC1=C(C=C(Cl)C=C1)C(=O)NC2=C(Cl)C=C(C=C2)[N+]([O-])=O

InChI

InChIKey=ZBXRPLQCPHTHLM-UHFFFAOYSA-N

InChI=1S/C13H8Cl2N2O4.H2O/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15;/h1-6,18H,(H,16,19);1H2

HIDE SMILES / InChI

Molecular Formula	C13H8Cl2N2O4
Molecular Weight	327.12
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	H2O
Molecular Weight	18.0153
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.drugbank.ca/drugs/DB06803
Curator's Comment: Description was created based on several sources, including https://www.drugs.com/mmx/niclosamide.html

Niclosamide is an antihelminth used against tapeworm infections. It may act by the uncoupling of the electron transport chain to ATP synthase. The disturbance of this crucial metabolic pathway prevents creation of adenosine tri-phosphate (ATP), an essential molecule that supplies energy for metabolism. Niclosamide works by killing tapeworms on contact. Adult worms (but not ova) are rapidly killed, presumably due to uncoupling of oxidative phosphorylation or stimulation of ATPase activity. The killed worms are then passed in the stool or sometimes destroyed in the intestine. Niclosamide may work as a molluscicide by binding to and damaging DNA. Niclosamide is used for the treatment of tapeworm and intestinal fluke infections: Taenia saginata (Beef Tapeworm), Taenia solium (Pork Tapeworm), Diphyllobothrium latum (Fish Tapeworm), Fasciolopsis buski (large intestinal fluke). Niclosamide is also used as a molluscicide in the control of schistosomiasis. Niclosamide was marketed under the trade name Niclocide, now discontinued.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Potency
Staphylococcus aureus 65 Target ID: CHEMBL352 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25897961	Inhibitor 8228
Enterococcus faecium 5 Target ID: CHEMBL357 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25897961	Inhibitor 8228
Cytochrome P450 1A2 72 Target ID: CHEMBL3356 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11124226	Inhibitor 8228	2.7 µM [Ki]
Hymenolepis nana 2 Target ID: CHEMBL612450 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6841958	Inhibitor 8228
Target ID: Taenia saginata Sources: https://www.ncbi.nlm.nih.gov/pubmed/3425963	Inhibitor 8228
MCF7 21 Target ID: CHEMBL387 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27545321	Inhibitor 8228	45.0 µM [IC50]
DNA 247 Target ID: CHEMBL2366043 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12392939	Inhibitor 8228

Conditions

Condition	Modality	Highest Phase	Product
Diphyllobothriasis 2 Sources: https://www.drugs.com/cons/niclosamide.html	Curative	Approved 8360	NICLOCIDE Approved Use Diphyllobothriasis (treatment)—Niclosamide is indicated in the treatment of diphyllobothriasis caused by Diphyllobothrium latum (broad or fish tapeworm). Hymenolepiasis (treatment)—Niclosamide is indicated in the treatment of hymenolepiasis caused by Hymenolepis nana (dwarf tapeworm) and [H. diminuta (rat tapeworm)] . Taeniasis (treatment)—Niclosamide is indicated in the treatment of taeniasis caused by Taenia saginata (beef tapeworm) and [T. solium (pork tapeworm)] . [Dipylidiasis (treatment)]—Niclosamide is used in the treatment of dipylidiasis caused by Dipylidium caninum (dog and cat tapeworm). Launch Date 3.90095995E11
Hymenolepiasis 2 Sources: https://www.drugs.com/cons/niclosamide.html	Curative	Approved 8360	NICLOCIDE Approved Use Diphyllobothriasis (treatment)—Niclosamide is indicated in the treatment of diphyllobothriasis caused by Diphyllobothrium latum (broad or fish tapeworm). Hymenolepiasis (treatment)—Niclosamide is indicated in the treatment of hymenolepiasis caused by Hymenolepis nana (dwarf tapeworm) and [H. diminuta (rat tapeworm)] . Taeniasis (treatment)—Niclosamide is indicated in the treatment of taeniasis caused by Taenia saginata (beef tapeworm) and [T. solium (pork tapeworm)] . [Dipylidiasis (treatment)]—Niclosamide is used in the treatment of dipylidiasis caused by Dipylidium caninum (dog and cat tapeworm). Launch Date 3.90095995E11
Taeniasis 2 Sources: https://www.drugs.com/cons/niclosamide.html	Curative	Approved 8360	NICLOCIDE Approved Use Diphyllobothriasis (treatment)—Niclosamide is indicated in the treatment of diphyllobothriasis caused by Diphyllobothrium latum (broad or fish tapeworm). Hymenolepiasis (treatment)—Niclosamide is indicated in the treatment of hymenolepiasis caused by Hymenolepis nana (dwarf tapeworm) and [H. diminuta (rat tapeworm)] . Taeniasis (treatment)—Niclosamide is indicated in the treatment of taeniasis caused by Taenia saginata (beef tapeworm) and [T. solium (pork tapeworm)] . [Dipylidiasis (treatment)]—Niclosamide is used in the treatment of dipylidiasis caused by Dipylidium caninum (dog and cat tapeworm). Launch Date 3.90095995E11

C_max

Value	Dose	Co-administered	Analyte	Population
0.665 μg/mL EXPERIMENT https://ascopubs.org/doi/abs/10.1200/JCO.2018.36.15_suppl.e14536	2 g single, oral dose: 2 g route of administration: Oral experiment type: SINGLE co-administered:		NICLOSAMIDE plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN

AUC

Value	Dose	Co-administered	Analyte	Population
1413 ng × h/mL EXPERIMENT http://www.airitilibrary.com/Publication/alDetailedMesh?docid=10219498-200612-14-4-329-333-a	2 mg/kg single, intravenous dose: 2 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered:		NICLOSAMIDE plasma	Rattus norvegicus population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
6.7 h EXPERIMENT http://www.airitilibrary.com/Publication/alDetailedMesh?docid=10219498-200612-14-4-329-333-a	2 mg/kg single, intravenous dose: 2 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered:		NICLOSAMIDE plasma	Rattus norvegicus population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

Doses

Dose	Population	Adverse events
1000 mg 3 times / day steady, oral Dose: 1000 mg, 3 times / day Route: oral Route: steady Dose: 1000 mg, 3 times / day Co-administed with:: enzalutamide(160 mg, oral, daily) Sources: https://pubmed.ncbi.nlm.nih.gov/29856824	unhealthy n = 2 Health Status: unhealthy Condition: castration-resistant prostate cancer Sex: M Population Size: 2 Sources: https://pubmed.ncbi.nlm.nih.gov/29856824	DLT: Nausea, Vomiting... Dose limiting toxicities: Nausea (grade 3, 2 patients) Vomiting (grade 3, 2 patients) Diarrhea (grade 3, 2 patients) Colitis (grade 3, 2 patients) Sources: https://pubmed.ncbi.nlm.nih.gov/29856824

AEs

AE	Significance	Dose	Population
Colitis	grade 3, 2 patients DLT	1000 mg 3 times / day steady, oral Dose: 1000 mg, 3 times / day Route: oral Route: steady Dose: 1000 mg, 3 times / day Co-administed with:: enzalutamide(160 mg, oral, daily) Sources: https://pubmed.ncbi.nlm.nih.gov/29856824	unhealthy n = 2 Health Status: unhealthy Condition: castration-resistant prostate cancer Sex: M Population Size: 2 Sources: https://pubmed.ncbi.nlm.nih.gov/29856824
Diarrhea	grade 3, 2 patients DLT	1000 mg 3 times / day steady, oral Dose: 1000 mg, 3 times / day Route: oral Route: steady Dose: 1000 mg, 3 times / day Co-administed with:: enzalutamide(160 mg, oral, daily) Sources: https://pubmed.ncbi.nlm.nih.gov/29856824	unhealthy n = 2 Health Status: unhealthy Condition: castration-resistant prostate cancer Sex: M Population Size: 2 Sources: https://pubmed.ncbi.nlm.nih.gov/29856824
Nausea	grade 3, 2 patients DLT	1000 mg 3 times / day steady, oral Dose: 1000 mg, 3 times / day Route: oral Route: steady Dose: 1000 mg, 3 times / day Co-administed with:: enzalutamide(160 mg, oral, daily) Sources: https://pubmed.ncbi.nlm.nih.gov/29856824	unhealthy n = 2 Health Status: unhealthy Condition: castration-resistant prostate cancer Sex: M Population Size: 2 Sources: https://pubmed.ncbi.nlm.nih.gov/29856824
Vomiting	grade 3, 2 patients DLT	1000 mg 3 times / day steady, oral Dose: 1000 mg, 3 times / day Route: oral Route: steady Dose: 1000 mg, 3 times / day Co-administed with:: enzalutamide(160 mg, oral, daily) Sources: https://pubmed.ncbi.nlm.nih.gov/29856824	unhealthy n = 2 Health Status: unhealthy Condition: castration-resistant prostate cancer Sex: M Population Size: 2 Sources: https://pubmed.ncbi.nlm.nih.gov/29856824

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
substrate 1709	inhibitor 1752 activator 21 substrate 1010	substrate 1193

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
CYP1A2 1509	CYP1A1 348 CYP1A2 1032 CYP1B1 92 CYP2B6 660 CYP2C8 688 CYP2C19 985 CYP2E1 648 CYP3A5 391 UGT1A1 418 UGT1A3 422 UGT1A4 347 UGT1A6 307 UGT1A7 236 UGT1A8 283 UGT1A9 380 UGT1A10 290 UGT2B4 249 UGT2B7 389 UGT2B15 203 UGT2B17 213

Drug as perpetrator

Target	Modality	Activity
CYP1A2 1673	inhibitor 3240 Sources: https://pubmed.ncbi.nlm.nih.gov/11124226/	yes [Ki 2.7 uM]
CYP2C9 1803	inhibitor 3240 Sources: https://pubmed.ncbi.nlm.nih.gov/11124226/	yes [Ki 6 uM]
CYP2C9 1803	activator 210 Sources: https://pubmed.ncbi.nlm.nih.gov/11124226/	yes

Drug as victim

Target	Modality	Activity
CYP1B1 92	substrate 3326 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 3.0	no
CYP2B6 660	substrate 3326 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 3.0	no
CYP2C19 985	substrate 3326 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 3.0	no
CYP2C8 688	substrate 3326 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 3.0	no
CYP2C9 1010	substrate 3326 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 3.0	no
CYP2D6 1193	substrate 3326 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 3.0	no
CYP2E1 648	substrate 3326 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 3.0	no
CYP3A4 1709	substrate 3326 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 3.0	no
CYP3A5 391	substrate 3326 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 3.0	no
UGT1A4 347	substrate 3326 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 7.0	no
UGT1A6 307	substrate 3326 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 7.0	no
UGT2B15 203	substrate 3326 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 7.0	no
UGT2B17 213	substrate 3326 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 7.0	no
UGT2B4 249	substrate 3326 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 7.0	no
CYP1A1 348	substrate 3326 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 6.0	yes
CYP1A2 1032	substrate 3326 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 6.0	yes
UGT1A1 418	substrate 3326 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 7.0	yes
UGT1A10 290	substrate 3326 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 7.0	yes
UGT1A3 422	substrate 3326 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 7.0	yes
UGT1A7 236	substrate 3326 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 7.0	yes
UGT1A8 283	substrate 3326 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 7.0	yes
UGT1A9 380	substrate 3326 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 7.0	yes
UGT2B7 389	substrate 3326 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 7.0	yes

Sourcing

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B2-0772	http://www.3bsc.com/index/pro_info.php?id=20128
AA Blocks	AA0035B8	http://www.aablocks.com/goods/Goods/detail?id=AA0035B8
AHH Chemical co.,ltd	API-1745	http://www.ahhchemical.com/product/API-1745.html
AK Scientific, Inc. (AKSCI)	I012	http://www.aksci.com/item_detail.php?cat=I012
Aaron Chemicals	AR003630	http://www.aaronchem.com/50-65-7
AbMole Bioscience	M2055	http://www.abmole.com/products/niclosamide.html
Acadechem	ACDS-028814	http://www.acadechemical.com/product/103513
Achemtek	1ST20493	http://achemtek.com/50-65-7-2
Achemtek	0104-015424	http://www.achemtek.com/50-65-7
Acros Organics	AC461840250	https://www.fishersci.com/shop/products/niclosamide-97-acros-organics-1/AC461840250
Acros Organics	AC461841000	https://www.fishersci.com/shop/products/niclosamide-97-acros-organics/AC461841000
Alfa Chemistry	AP50657	https://reagents.alfa-chemistry.com/product/niclosamide-cas-50-65-7-cas-50-65-7-12166.html
Angene	AGN-PC-08WHBK	http://www.angenechemical.com/productshow/AGN-PC-08WHBK.html
ApexBio Technology	B2283	http://www.apexbt.com/niclosamide.html
Ark Pharm	AK173020	http://www.arkpharminc.com/products/50-65-7.html
Aurora Fine Chemicals LLC	K04.832.702	http://online.aurorafinechemicals.com/info?ID=K04.832.702
Aurum Pharmatech LLC	T7903	http://www.Aurumpharmatech.com/Product/ProductDetails/T7903
AvaChem Scientific	6587	https://www.avachem.com/productSearch.asp?6587
BioChemPartner	BCP22958	http://www.biochempartner.com/50-65-7-BCP22958
BioCrick	BCC5081	http://www.biocrick.com/Niclosamide-BCC5081.html
BioSynth	Q-201469	https://www.biosynth.com/en/products/life-science/enzyme-substrates-reagents/products/Q-201469.html
Chem Scene	CS-2618	http://www.chemscene.com/50-65-7.html
ChemMol	49409397	http://www.chemmol.com/chemmol/49409397.html
ChemMol	99097726	http://www.chemmol.com/chemmol/99097726.html
Chemenu	CM110596	http://www.chemenu.com/products/CM110596
Chemspace	CSSB00000764091	https://chem-space.com/CSSB00000764091
Debye Scientific	DB-051812	http://www.debyesci.com/cas_50-65-7.html
EMD Biosciences	481909	http://www.emdbiosciences.com/product/481909
EMD Millipore	481909	http://www.emdbiosciences.com/product/481909
Enamine	Z57902203	https://www.enaminestore.com/catalog/Z57902203
Finetech	FT-0603220	http://www.finetechnology-ind.com/prod/detail/pub/50-65-7.html
Glentham Life Sciences	GA5338	http://www.glentham.com/products/product/GA5338/
Hello Bio	HB1435	https://www.hellobio.com/niclosamide.html
LGC Standards	DRE-A15510000AL-100	https://www.lgcstandards.com/US/en/p/DRE-A15510000AL-100
LGC Standards	DRE-C15510000	https://www.lgcstandards.com/US/en/p/DRE-C15510000
LGC Standards	LGCFOR0361.00	https://www.lgcstandards.com/US/en/p/LGCFOR0361.00
LGC Standards	MM0361.00	https://www.lgcstandards.com/US/en/p/MM0361.00
Matrix Scientific	203850	https://www.matrixscientific.com/203850.html
MedChem Express	HY-B0497	https://www.medchemexpress.com/Niclosamide.html
Selleck Chemicals	S3030	http://www.selleckchem.com/products/niclosamide-niclocide.html
Sigma-Aldrich	N0560000_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/n0560000?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	N3510_SIGMA	https://www.sigmaaldrich.com/catalog/product/sigma/n3510?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sinfoo Biotech	S013157	http://www.sinfoobiotech.com/product/1016555
Smolecule	S548510	http://www.smolecule.com/products/s548510
Speranza Chemical Co., Ltd.	C057	http://www.speranzachem.com/products-50-65-7.html
Synblock Inc	SB19414	http://www.synblock.com/product/50-65-7.html
THE BioTek	bt-287919	https://www.thebiotek.com/product/inhibitors/bt-287919
Tocris	4079	https://www.tocris.com/products/niclosamide_4079
VladaChem	VL264556-100G	https://www.vladachem.com/product.php?products=50-65-7
Yuhao Chemical	HL1041	http://www.chemyuhao.com/50-65-7.html
abcr GmbH	AB372324	http://www.abcr.com/shop/en/AB372324
eNovation Chemicals	D672942	https://www.enovationchem.com/ProductDetails.asp?ProductID=D672942
eNovation Chemicals	D765674	https://www.enovationchem.com/ProductDetails.asp?ProductID=D765674
iChemical	EBD38831	http://www.ichemical.com/chemicals/cas-50-65-7
mcule	MCULE-9985514311	https://mcule.com/MCULE-9985514311/

PubMed

Title	Date	PubMed
[Preliminary test of the effect of niclosamide-impregnated tissue for the prevention of Schistosoma japonicum infection].	2003	15108533
Human Monieziasis expansa: the first Egyptian parastic zoonosis.	2004 Aug	15287174
Nitazoxanide: a new broad spectrum antiparasitic agent.	2004 Feb	15482170
Aqueous photolysis of niclosamide.	2004 Feb 25	14969544
Preparation and physicochemical properties of niclosamide anhydrate and two monohydrates.	2004 Jan 28	14706253
[Efficacy of the Russian anthelmintic agent trichlorophen].	2004 Jan-Mar	15042750
Molluscicidal effect of nicotinanilide and its intermediate compounds against a freshwater snail Lymnaea luteola, the vector of animal schistosomiasis.	2004 Mar	15250477
Adverse drug reactions to anthelmintics.	2004 Mar	14749518
Species identification after treatment for human taeniasis.	2004 Mar 20	15043964
Purging the worm: management of Taenia solium taeniasis.	2004 Mar 20	15043955
Infestation of the human intestine by the millipede, Nopoiulus kochii.	2004 Sep	15347400
[Treatment of intestinal helminthiasis with albendazole].	2005 Apr-Jun	15984617
Impact of certain plants and synthetic molluscicides on some fresh water snails and fish.	2005 Dec	16333905
Residues of the lampricides 3-trifluoromethyl-4-nitrophenol and niclosamide in muscle tissue of rainbow trout.	2005 Jun 29	15969516
Taeniasis and cysticercosis in housemaids working in affluent neighborhoods in Lima, Peru.	2005 Sep	16172470
Effect of 4-sulphonato-calix[n]arenes and cyclodextrins on the solubilization of niclosamide, a poorly water soluble anthelmintic.	2005 Sep 2	16146345
Potential antivirals and antiviral strategies against SARS coronavirus infections.	2006 Apr	16597209
Synthesis of furo-salicylanilides and their heterocyclic derivatives with anticipated molluscicidal activity.	2006 Aug	16832819
Catalysis of NADH-->NADP+ transhydrogenation by adult Hymenolepis diminuta mitochondria.	2006 Feb	16328369
[Cleaning and molluscicide treatment for schistosomiasis control].	2006 Jan-Mar	17037230
Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.	2006 Jun 9	16789813
Lower-rim substituted calixarenes and their applications.	2007	17611612
A studies on chemical control of S. mansoni intermediate host.	2007 Aug 1	19070141
Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus.	2007 Aug 23	17663539
[Study on molluscicidal effect of the extracts from sarcotesta of Ginkgo biloba].	2007 Feb 28	17639699
Large water management projects and schistosomiasis control, Dongting Lake region, China.	2007 Jul	18214167
5(6)-Carboxyfluorescein diacetate as an indicator of Caenorhabditis elegans viability for the development of an in vitro anthelmintic drug assay.	2007 Mar 30	19071538
[Study on molluscicidal effect of chlorosalicylicamide].	2007 Oct	18441997
Taeniasis and its socio-economic implication in Awassa town and its surroundings, Southern Ethiopia.	2007 Oct	18085135
Community acceptability of the use of low-dose niclosamide (Bayluscide), as a molluscicide in the control of human schistosomiasis in Sahelian Cameroon.	2007 Sep	17716430
Tribendimidine and albendazole for treating soil-transmitted helminths, Strongyloides stercoralis and Taenia spp.: open-label randomized trial.	2008	18923706
[Human infection due to Bertiella sp (cestode: Anoplocephalidae) in a man originating from Yemen in Algeria].	2008 Apr	18543702
In vitro trypanocidal activity of the anti-helminthic drug niclosamide.	2008 Apr	18226810
[Snail control by using soil pasting mixed with niclosamide].	2008 Aug	19115619
Efficacy of temperature, and two commonly used molluscicides and fertilizers on Fasciola gigantica eggs.	2008 Aug	18853633
Successful treatment of niclosamide- and praziquantel-resistant beef tapeworm infection with nitazoxanide.	2008 Jan	17962058
A novel molluscicidal formulation of niclosamide.	2008 Jul	18454287
Voltammetric Behavior of o-Nitrophenol and Damage to DNA.	2008 Mar	19325751
Hymenolepis diminuta: mitochondrial transhydrogenase as an additional site for anaerobic phosphorylation.	2008 May	18262524
Potential of some monoterpenoids and their new N-methyl carbamate derivatives against Schistosomiasis snail vector, Biomphalaria alexandrina.	2008 Nov	17692915
Harnessing the wealth of Chinese scientific literature: schistosomiasis research and control in China.	2008 Sep 30	18826598
Taenia solium cysticercosis hotspots surrounding tapeworm carriers: clustering on human seroprevalence but not on seizures.	2009	19172178
A novel method for oral delivery of apolipoprotein mimetic peptides synthesized from all L-amino acids.	2009 Aug	19225094
A retrospective analysis of prevalence of gastrointestinal parasites among school children in the Palajunoj Valley of Guatemala.	2009 Feb	19248646
Spatial epidemiology in zoonotic parasitic diseases: insights gained at the 1st International Symposium on Geospatial Health in Lijiang, China, 2007.	2009 Feb 4	19193214
Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening.	2009 Jul 14	19597541
Diphyllobothrium latum identified by capsule endoscopy--an unusual cause of iron-deficiency anemia.	2009 Jun	19565041
The autonomous notch signal pathway is activated by baicalin and baicalein but is suppressed by niclosamide in K562 cells.	2009 Mar 1	19160421
Multi-residue determination of phenolic and salicylanilide anthelmintics and related compounds in bovine kidney by liquid chromatography-tandem mass spectrometry.	2009 Nov 13	19426989
Halogenated pesticide transformation by a laccase-mediator system.	2009 Oct	19695672

Patents

Sample Use Guides

In Vivo Use Guide

Adults—2 grams as a single dose. Treatment may be repeated in seven days if needed.

Route of Administration: Oral

In Vitro Use Guide

Niclosamide (0.2 ug/ml) was effective against Diplozoon paradoxum after an exposure of 90 min and 45 min in vitro.

Substance Class	Chemical Created by `admin` on `Thu Jul 06 02:05:54 UTC 2023` Edited by `admin` on `Thu Jul 06 02:05:54 UTC 2023`
Record UNII	20Z25R1145
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NICLOSAMIDE MONOHYDRATE

Common Name

English

NICLOSAMIDE MONOHYDRATE [WHO-IP]

Common Name

English

2',5-DICHLORO-4'-NITROSALICYLANILIDE MONOHYDRATE

Systematic Name

English

NICLOSAMIDE MONOHYDRATE [EP IMPURITY]

Common Name

English

5-CHLORO-N-(2-CHLORO-4-NITROPHENYL)-2-HYDROXYBENZAMIDE MONOHYDRATE

Systematic Name

English

BENZAMIDE, 5-CHLORO-N-(2-CHLORO-4-NITROPHENYL)-2-HYDROXY-, HYDRATE (1:1)

Systematic Name

English

Niclosamide monohydrate [WHO-DD]

Common Name

English

NICLOSAMIDE MONOHYDRATE [EP MONOGRAPH]

Common Name

English

NICLOSAMIDE MONOHYDRATE [MART.]

Common Name

English

Code System Code Type Description

WHO INTERNATIONAL PHARMACOPEIA

NICLOSAMIDE MONOHYDRATE